Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
GR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GR transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; DNA binding protein; Transcription factor; Nuclear receptor
Cellular Component: nucleoplasm; membrane; mitochondrial matrix; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein dimerization activity; glucocorticoid receptor activity; protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor activity; steroid binding
Biological Process: transcription from RNA polymerase II promoter; glucocorticoid metabolic process; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; adrenal gland development; positive regulation of neuron apoptosis; regulation of glucocorticoid biosynthetic process; gene expression; regulation of gluconeogenesis; chromatin modification; signal transduction
Reference #:  P04150 (UniProtKB)
Alt. Names/Synonyms: GCCR; GCR; Glucocorticoid receptor; GR; GRL; NR3C1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Symbols: NR3C1
Molecular weight: 85,659 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GR

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, induced: S211‑p
apoptosis, inhibited: S404‑p
transcription, altered: S134‑p, S211‑p
transcription, induced: S203‑p, S211‑p, S226‑p, S404‑p
transcription, inhibited: S203‑p, S211‑p, S226‑p
activity, inhibited: S203‑p, S211‑p, S226‑p, S404‑p
intracellular localization: S226‑p, S404‑p
molecular association, regulation: S203‑p, S211‑p, S226‑p, S404‑p
protein conformation: S211‑p, S404‑p
protein degradation: S404‑p
protein stabilization: S211‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S6-p __MDSKEsLtPGREE
0 2 T8-p MDSKEsLtPGREENP
0 13 R23 SSVLAQERGDVMDFY
0 1 T32-p DVMDFYKtLRGGAtV
0 2 R34 MDFYKtLRGGAtVKV
0 1 T38-p KtLRGGAtVKVSAss
0 7 S44-p AtVKVSAssPSLAVA
0 5 S45-p tVKVSAssPSLAVAS
3 0 S113 QQGQISLSSGETDLK
3 6 S134-p ANLNRSTsVPENPKS
2 0 S141 sVPENPKSSASTAVS
6 4 A150 ASTAVSAAPTEKEFP
0 1 T159 TEKEFPKTHSDVSSE
0 1 G172 SEQQHLKGQTGTNGG
14 2 S203-p DLEFSSGsPGKETNE
28 0 S211-p PGKETNEsPWRSDLL
25 5 S226-p IDENCLLsPLAGEDD
1 4 S267-p NGDLVLSsPSNVTLP
5 0 K277-s NVTLPQVkTEKEDFI
0 1 K280 LPQVkTEKEDFIELC
5 0 K293-s LCTPGVIkQEKLGTV
2 0 P307 VYCQASFPGANIIGN
0 1 S395 VFSNGYSSPSMRPDV
1 3 S404-p SMRPDVSsPPSSSST
1 0 K419 ATTGPPPKLCLVCSD
1 0 K480-a CPACRYRkCLQAGMN
1 0 K492-a GMNLEARkTkkKIkG
2 0 K494-a NLEARkTkkKIkGIQ
2 0 K495-a LEARkTkkKIkGIQQ
0 2 K498-u RkTkkKIkGIQQATT
1 1 S508 QQATTGVSQETSENP
0 2 K681-u SVPKDGLkSQELFDE
1 0 K703 ELGKAIVKREGNSSQ
4161 : Phospho-Glucocorticoid Receptor (Ser211) Antibody
  GR iso2  
S6 __MDSKESLTPGREE
T8 MDSKESLTPGREENP
R23 SSVLAQERGDVMDFY
T32 DVMDFYKTLRGGATV
R34 MDFYKTLRGGATVKV
T38 KTLRGGATVKVSASS
S44 ATVKVSASSPSLAVA
S45 TVKVSASSPSLAVAS
S113 QQGQISLSSGETDLK
S134 ANLNRSTSVPENPKS
S141 SVPENPKSSASTAVS
A150 ASTAVSAAPTEKEFP
T159 TEKEFPKTHSDVSSE
G172 SEQQHLKGQTGTNGG
S203 DLEFSSGSPGKETNE
S211 PGKETNESPWRSDLL
S226 IDENCLLSPLAGEDD
S267 NGDLVLSSPSNVTLP
K277 NVTLPQVKTEKEDFI
K280 LPQVKTEKEDFIELC
K293 LCTPGVIKQEKLGTV
P307 VYCQASFPGANIIGN
S395 VFSNGYSSPSMRPDV
S404 SMRPDVSSPPSSSST
K419 ATTGPPPKLCLVCSD
K480 CPACRYRKCLQAGMN
K492 GMNLEARKTKKKIKG
K494 NLEARKTKKKIKGIQ
K495 LEARKTKKKIKGIQQ
K498 RKTKKKIKGIQQATT
S508 QQATTGVSQETSENP
K681 SVPKDGLKSQELFDE
K703 ELGKAIVKREGNSSQ
  mouse

 
S6 __MDSKESLAPPGRD
A8 MDSKESLAPPGRDEV
R24-m1 SSLLGRGrGSVMDLY
T33 SVMDLYKTLrGGATV
R35-m1 MDLYKTLrGGATVKV
T39 KTLrGGATVKVSASs
S45 ATVKVSASsPSVAAA
S46-p TVKVSASsPSVAAAS
S122-p QQGQLGLsSGETDFR
S143 ANLNRSTSRPENPKs
S150-p SRPENPKsSTPAAGC
T159-p TPAAGCAtPTEKEFP
T168 TEKEFPQTHSDPSSE
S181-p SEQQNRKsQPGTNGG
S212-p DLEFSAGsPGKETNE
S220-p PGKETNEsPWRSDLL
S234-p LIDENLLsPLAGEDD
S275-p TGDTILSsPSSVALP
K285 SVALPQVKTEkDDFI
K288-u LPQVKTEkDDFIELC
K301 LCTPGVIKQEKLGPV
S315-p VYCQASFsGTNIIGN
S403 VFSNGYSSPGMRPDV
S412-p GMRPDVSsPPSSSST
K426-u TATGPPPkLCLVCSD
K487 CPACRYRKCLQAGMN
K499 GMNLEARKTKKKIkG
K501 NLEARKTKKKIkGIQ
K502 LEARKTKKKIkGIQQ
K505-u RKTKKKIkGIQQATA
S515 QQATAGVSQDTSENA
K687 SVPKEGLKSQELFDE
K709 ELGKAIVKREGNSSQ
4161 : Phospho-Glucocorticoid Receptor (Ser211) Antibody
  rat

 
S6 __MDSKESLAPPGRD
A8 MDSKESLAPPGRDEV
R24-m1 GSLLGQGrGSVMDFY
S33 SVMDFYKSLRGGATV
R35 MDFYKSLRGGATVKV
T39 KSLRGGATVKVSASS
S45 ATVKVSASSPSVAAA
S46 TVKVSASSPSVAAAS
S134 QQGQLGLSSGETDFR
S155-p ANLNRSTsVPENPKS
S162 sVPENPKSSTSATGC
T171-p TSATGCAtPTEKEFP
T180-p TEKEFPKtHSDASSE
S193 SEQQNRKSQTGTNGG
S224-p DLEFSAGsPSKDTNE
S232-p PSKDTNEsPWRSDLL
S246-p LIDENLLsPLAGEDD
S287-p TGDTILSsPSSVALP
K297-s SVALPQVkTEKDDFI
K300 LPQVkTEKDDFIELC
K313-s LCTPGVIkQEKLGPV
S327 VYCQASFSGTNIIGN
S415-p VFSNGYSsPGMRPDV
S424 GMRPDVSSPPSSSSA
K438 AATGPPPKLCLVCSD
K499 CPACRYRKCLQAGMN
K511 GMNLEARKTKKKIKG
K513 NLEARKTKKKIKGIQ
K514 LEARKTKKKIKGIQQ
K517 RKTKKKIKGIQQATA
S527-p QQATAGVsQDTSENP
K699 SVPKEGLKSQELFDE
K721-s ELGKAIVkREGNSSQ
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.