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GR (human)

Overview GR transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor Cellular Component: nucleoplasm; protein complex; membrane; mitochondrial matrix; cytoplasm; postsynaptic density; nucleolus; cytosol; nucleus Molecular Function: protein homodimerization activity; zinc ion binding; Hsp70 protein binding; Hsp90 protein binding; receptor tyrosine kinase binding; steroid binding; glucocorticoid receptor activity; protein binding; protein heterodimerization activity; sequence-specific DNA binding; double-stranded DNA binding; chromatin binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; circadian rhythm; response to arsenic; positive regulation of glutamate secretion; signal transduction; response to insulin stimulus; response to mercury ion; response to radiation; chromatin-mediated maintenance of transcription; positive regulation of neuron apoptosis; response to corticosterone stimulus; aging; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; adrenal gland development; regulation of glucocorticoid biosynthetic process; muscle atrophy; regulation of cell proliferation; glucocorticoid metabolic process; negative regulation of vascular permeability; gene expression; regulation of gluconeogenesis; brain development; response to activity; negative regulation of transforming growth factor beta receptor signaling pathway; lung development Reference #:  P04150 (UniProtKB) Alt. Names/Synonyms: GCCR; GCR; Glucocorticoid receptor; GR; GRL; NR3C1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Gene Symbols: NR3C1 Molecular weight: 85,659 Da Basal Isoelectric point: 6  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GR 1M2Z - A/D=521-777 (human) 1NHZ - A=500-777 (human) 1P93 - A/B/C/D=500-777 (human) 3BQD - A=525-777 (human) 3CLD - A/B=521-777 (human) 3E7C - A/B=521-777 (human) 3H52 - A/D/C/B=528-777 (human) 3K22 - A/B=521-777 (human) 3K23 - A/C/B=521-777 (human) 4HN5 - A/B=417-506 (human) 4HN6 - A/B=417-506 (human) 3MNE - A=527-783 (mouse) 3MNO - A=527-783 (mouse) 3MNP - A=527-783 (mouse) 1GDC - A=439-510 (rat) 1GLU - A/B=440-514 (rat) 1LAT - A/B=436-515 (rat) 1R4O - A/B=440-525 (rat) 1R4R - A/B=440-525 (rat) 1RGD - A=440-510 (rat) 2GDA - A=439-510 (rat) 3FYL - A/B=440-525 (rat) 3G6P - A/B=440-525 (rat) 3G6Q - A/B=440-525 (rat) 3G6R - A/B=440-525 (rat) 3G6T - A/B=440-525 (rat) 3G6U - A/B=440-525 (rat) 3G8U - A/B=440-525 (rat) 3G8X - A/B=440-525 (rat) 3G97 - A/B=440-525 (rat) 3G99 - A/B=440-525 (rat) 3G9I - A/B=440-525 (rat) 3G9J - A/B=440-525 (rat) 3G9M - A/B=440-525 (rat) 3G9O - A/B=440-525 (rat) 3G9P - A/B=440-525 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1M2Z 1NHZ 1P93 3BQD 3CLD 3E7C 3H52 3K22 3K23 4HN5 4HN6  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, induced: S211‑p apoptosis, inhibited: S404‑p transcription, altered: S134‑p, S203‑p, S211‑p, S226‑p, S404‑p inhibition: S203‑p, S211‑p, S226‑p, S404‑p intracellular localization: S226‑p, S404‑p molecular association, regulation: S203‑p, S211‑p, S226‑p, S404‑p protein conformation: S211‑p, S404‑p protein degradation: S404‑p protein stabilization: S211‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T8-p	MDSKESLtPGREENP
0	12		R23	SSVLAQERGDVMDFy
0	1		Y30-p	RGDVMDFyKtLRGGA
0	1		T32-p	DVMDFyKtLRGGAtV
0	1		R34	MDFyKtLRGGAtVKV
0	1		T38-p	KtLRGGAtVKVSAss
0	6		S44-p	AtVKVSAssPSLAVA
0	4		S45-p	tVKVSAssPSLAVAS
0	1		S56-p	AVASQSDsKQRRLLV
0	1		S79-p	NAQQPDLsKAVSLSM
0	1		Y89-p	VSLSMGLyMGEtEtK
0	1		T93-p	MGLyMGEtEtKVMGN
0	1		T95-p	LyMGEtEtKVMGNDL
3	0		S113	QQGQISLSSGETDLK
0	1		S132-p	SIANLNRstsVPENP
0	1		T133-p	IANLNRstsVPENPK
1	6		S134-p	ANLNRstsVPENPKS
2	0		S141	sVPENPKSSASTAVS
6	1		A150	ASTAVSAAPTEKEFP
0	1		G172	SEQQHLKGQTGTNGG
12	1		S203-p	DLEFSSGsPGKETNE
25	0		S211-p	PGKETNEsPWRSDLL
22	4		S226-p	IDENCLLsPLAGEDD
0	3		S267-p	NGDLVLSsPSNVTLP
4	0		K277-s	NVTLPQVkTEKEDFI
0	1		K280	LPQVkTEKEDFIELC
4	0		K293-s	LCTPGVIkQEkLGTV
0	1		K296-u	PGVIkQEkLGTVyCQ
0	1		Y301-p	QEkLGTVyCQAsFPG
0	1		S305-p	GTVyCQAsFPGANII
2	0		P307	VyCQAsFPGANIIGN
0	1		S317-p	NIIGNKMsAISVHGV
0	1		S395-p	VFSNGYSsPSMRPDV
1	3		S404-p	SMRPDVSsPPSSSST
1	0		K419	ATTGPPPKLCLVCSD
1	0		K480-a	CPACRYRkCLQAGMN
1	0		K492-a	GMNLEARkTkkKIkG
2	0		K494-a	NLEARkTkkKIkGIQ
2	0		K495-a	LEARkTkkKIkGIQQ
0	2		K498-u	RkTkkKIkGIQQATT
1	1		S508	QQATTGVSQETSENP
0	2		K681-u	SVPKDGLkSQELFDE

	GR iso2
T8	MDSKESLTPGREENP
R23	SSVLAQERGDVMDFY
Y30	RGDVMDFYKTLRGGA
T32	DVMDFYKTLRGGATV
R34	MDFYKTLRGGATVKV
T38	KTLRGGATVKVSASS
S44	ATVKVSASSPSLAVA
S45	TVKVSASSPSLAVAS
S56	AVASQSDSKQRRLLV
S79	NAQQPDLSKAVSLSM
Y89	VSLSMGLYMGETETK
T93	MGLYMGETETKVMGN
T95	LYMGETETKVMGNDL
S113	QQGQISLSSGETDLK
S132	SIANLNRSTSVPENP
T133	IANLNRSTSVPENPK
S134	ANLNRSTSVPENPKS
S141	SVPENPKSSASTAVS
A150	ASTAVSAAPTEKEFP
G172	SEQQHLKGQTGTNGG
S203	DLEFSSGSPGKETNE
S211	PGKETNESPWRSDLL
S226	IDENCLLSPLAGEDD
S267	NGDLVLSSPSNVTLP
K277	NVTLPQVKTEKEDFI
K280	LPQVKTEKEDFIELC
K293	LCTPGVIKQEKLGTV
K296	PGVIKQEKLGTVYCQ
Y301	QEKLGTVYCQASFPG
S305	GTVYCQASFPGANII
P307	VYCQASFPGANIIGN
S317	NIIGNKMSAISVHGV
S395	VFSNGYSSPSMRPDV
S404	SMRPDVSSPPSSSST
K419	ATTGPPPKLCLVCSD
K480	CPACRYRKCLQAGMN
K492	GMNLEARKTKKKIKG
K494	NLEARKTKKKIKGIQ
K495	LEARKTKKKIKGIQQ
K498	RKTKKKIKGIQQATT
S508	QQATTGVSQETSENP
K681	SVPKDGLKSQELFDE

	mouse
A8	MDSKESLAPPGRDEV
R24-m1	SSLLGRGrGSVMDLY
Y31	rGSVMDLYKTLrGGA
T33	SVMDLYKTLrGGATV
R35-m1	MDLYKTLrGGATVKV
T39	KTLrGGATVKVSASs
S45	ATVKVSASsPSVAAA
S46-p	TVKVSASsPSVAAAS
S57	AAASQADSKQQRILL
S88	QQPQPDLSKAVSLSM
Y98	VSLSMGLYMGETETK
T102	MGLYMGETETKVMGN
T104	LYMGETETKVMGNDL
S122-p	QQGQLGLsSGETDFR
S141	SIANLNRSTSRPENP
T142	IANLNRSTSRPENPK
S143	ANLNRSTSRPENPKs
S150-p	SRPENPKsSTPAAGC
T159-p	TPAAGCAtPTEKEFP
S181-p	SEQQNRKsQPGTNGG
S212-p	DLEFSAGsPGKETNE
S220-p	PGKETNEsPWRSDLL
S234-p	LIDENLLsPLAGEDD
S275-p	TGDTILSsPSSVALP
K285	SVALPQVKTEkDDFI
K288-u	LPQVKTEkDDFIELC
K301	LCTPGVIKQEKLGPV
K304	PGVIKQEKLGPVYCQ
Y309	QEKLGPVYCQASFsG
S313	GPVYCQASFsGTNII
S315-p	VYCQASFsGTNIIGN
S325	NIIGNKMSAISVHGV
S403	VFSNGYSSPGMRPDV
S412-p	GMRPDVSsPPSSSST
K426-u	TATGPPPkLCLVCSD
K487	CPACRYRKCLQAGMN
K499	GMNLEARKTKKKIkG
K501	NLEARKTKKKIkGIQ
K502	LEARKTKKKIkGIQQ
K505-u	RKTKKKIkGIQQATA
S515	QQATAGVSQDTSENA
K687	SVPKEGLKSQELFDE

	rat
A8	MDSKESLAPPGRDEV
R24-m1	GSLLGQGrGSVMDFY
Y31	rGSVMDFYKSLRGGA
S33	SVMDFYKSLRGGATV
R35	MDFYKSLRGGATVKV
T39	KSLRGGATVKVSASS
S45	ATVKVSASSPSVAAA
S46	TVKVSASSPSVAAAS
S57	AAASQADSKQQRILL
S100	QQQQPDLSKAVSLSM
Y110	VSLSMGLYMGETETK
T114	MGLYMGETETKVMGN
T116	LYMGETETKVMGNDL
S134	QQGQLGLSSGETDFR
S153	SIANLNRSTsVPENP
T154	IANLNRSTsVPENPK
S155-p	ANLNRSTsVPENPKS
S162	sVPENPKSSTSATGC
T171-p	TSATGCAtPTEKEFP
S193	SEQQNRKSQTGTNGG
S224-p	DLEFSAGsPSKDTNE
S232-p	PSKDTNEsPWRSDLL
S246-p	LIDENLLsPLAGEDD
S287-p	TGDTILSsPSSVALP
K297-s	SVALPQVkTEKDDFI
K300	LPQVkTEKDDFIELC
K313-s	LCTPGVIkQEKLGPV
K316	PGVIkQEKLGPVYCQ
Y321	QEKLGPVYCQASFSG
S325	GPVYCQASFSGTNII
S327	VYCQASFSGTNIIGN
S337	NIIGNKMSAISVHGV
S415-p	VFSNGYSsPGMRPDV
S424	GMRPDVSSPPSSSSA
K438	AATGPPPKLCLVCSD
K499	CPACRYRKCLQAGMN
K511	GMNLEARKTKKKIKG
K513	NLEARKTKKKIKGIQ
K514	LEARKTKKKIKGIQQ
K517	RKTKKKIKGIQQATA
S527-p	QQATAGVsQDTSENP
K699	SVPKEGLKSQELFDE

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