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Protein Page:
GR (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GR transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; Mitochondrial; DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; membrane; mitochondrial matrix; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: protein dimerization activity; protein binding; glucocorticoid receptor activity; zinc ion binding; transcription factor activity; steroid binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; adrenal gland development; regulation of glucocorticoid biosynthetic process; chromatin modification; signal transduction; glucocorticoid mediated signaling; glucocorticoid metabolic process; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; glucocorticoid receptor signaling pathway; regulation of gluconeogenesis; gene expression; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P04150 (UniProtKB)
Alt. Names/Synonyms: GCCR; GCR; Glucocorticoid receptor; GR; GRL; NR3C1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Symbols: NR3C1
Molecular weight: 85,659 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GR

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S211‑p
apoptosis, inhibited: S404‑p
transcription, altered: S134‑p, S211‑p
transcription, induced: S203‑p, S211‑p, S226‑p, S404‑p
transcription, inhibited: S134‑p, S203‑p, S211‑p, S226‑p
activity, inhibited: S203‑p, S211‑p, S226‑p, S404‑p
intracellular localization: S134‑p, S226‑p, S404‑p
molecular association, regulation: S203‑p, S211‑p, S226‑p, S404‑p
protein conformation: S211‑p, S404‑p
protein degradation: S404‑p
protein stabilization: S211‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S6-p __MDSKEsLtPGREE
0 3 T8-p MDSKEsLtPGREENP
0 13 R23 SSVLAQERGDVMDFy
0 3 Y30-p RGDVMDFyKtLRGGA
0 1 T32-p DVMDFyKtLRGGAtV
0 2 R34 MDFyKtLRGGAtVKV
0 1 T38-p KtLRGGAtVKVSAss
0 7 S44-p AtVKVSAssPSLAVA
0 5 S45-p tVKVSAssPSLAVAS
0 1 S54-p SLAVASQsDsKQRRL
0 1 S56-p AVASQsDsKQRRLLV
0 1 S79-p NAQQPDLsKAVSLSM
0 1 Y89-p VSLSMGLyMGEtEtK
0 1 T93-p MGLyMGEtEtKVMGN
0 1 T95-p LyMGEtEtKVMGNDL
3 0 S113 QQGQISLSSGETDLK
0 1 S125-p DLKLLEEsIANLNRs
0 2 S132-p sIANLNRstsVPENP
0 1 T133-p IANLNRstsVPENPK
3 9 S134-p ANLNRstsVPENPKS
2 0 S141 sVPENPKSSASTAVS
0 1 A143 PENPKSSASTAVSAA
6 5 A150 ASTAVSAAPTEkEFP
0 1 T152 TAVSAAPTEkEFPKT
0 1 K154-ac VSAAPTEkEFPKTHS
0 1 T159 TEkEFPKTHSDVSSE
0 1 G172 SEQQHLKGQTGTNGG
14 3 S203-p DLEFSSGsPGKEtNE
0 1 T208-p SGsPGKEtNEsPWRS
28 0 S211-p PGKEtNEsPWRSDLL
25 5 S226-p IDENCLLsPLAGEDD
0 1 N260 TKPKIKDNGDLVLSs
0 1 L263 KIKDNGDLVLSsPSN
0 1 S266 DNGDLVLSsPSNVtL
1 6 S267-p NGDLVLSsPSNVtLP
0 1 S269 DLVLSsPSNVtLPQV
0 1 N270 LVLSsPSNVtLPQVk
0 1 T272-p LSsPSNVtLPQVkTE
5 0 K277-sm NVtLPQVkTEKEDFI
0 1 K280 LPQVkTEKEDFIELC
0 1 T288-p EDFIELCtPGVIkQE
5 0 K293-sm LCtPGVIkQEkLGTV
0 1 K296-ub PGVIkQEkLGTVyCQ
0 2 Y301-p QEkLGTVyCQAsFPG
0 1 S305-p GTVyCQAsFPGANII
2 0 P307 VyCQAsFPGANIIGN
0 1 S317-p NIIGNKMsAISVHGV
0 1 S390-p FPGRTVFsNGYSSPS
0 1 S395 VFsNGYSSPSMRPDV
1 4 S404-p SMRPDVSsPPSSSST
1 0 K419 ATTGPPPKLCLVCSD
1 0 K480-ac CPACRYRkCLQAGMN
1 0 K492-ac GMNLEARkTkkKIkG
2 0 K494-ac NLEARkTkkKIkGIQ
2 0 K495-ac LEARkTkkKIkGIQQ
0 2 K498-ub RkTkkKIkGIQQATT
1 1 S508 QQATTGVSQETSENP
0 2 K681-ub SVPKDGLkSQELFDE
1 0 K703 ELGKAIVKREGNSSQ
4161 : Phospho-Glucocorticoid Receptor (Ser211) Antibody
  GR iso2  
S6 __MDSKESLTPGREE
T8 MDSKESLTPGREENP
R23 SSVLAQERGDVMDFY
Y30 RGDVMDFYKTLRGGA
T32 DVMDFYKTLRGGATV
R34 MDFYKTLRGGATVKV
T38 KTLRGGATVKVSASS
S44 ATVKVSASSPSLAVA
S45 TVKVSASSPSLAVAS
S54 SLAVASQSDSKQRRL
S56 AVASQSDSKQRRLLV
S79 NAQQPDLSKAVSLSM
Y89 VSLSMGLYMGETETK
T93 MGLYMGETETKVMGN
T95 LYMGETETKVMGNDL
S113 QQGQISLSSGETDLK
S125 DLKLLEESIANLNRS
S132 SIANLNRSTSVPENP
T133 IANLNRSTSVPENPK
S134 ANLNRSTSVPENPKS
S141 SVPENPKSSASTAVS
A143 PENPKSSASTAVSAA
A150 ASTAVSAAPTEKEFP
T152 TAVSAAPTEKEFPKT
K154 VSAAPTEKEFPKTHS
T159 TEKEFPKTHSDVSSE
G172 SEQQHLKGQTGTNGG
S203 DLEFSSGSPGKETNE
T208 SGSPGKETNESPWRS
S211 PGKETNESPWRSDLL
S226 IDENCLLSPLAGEDD
N260 TKPKIKDNGDLVLSS
L263 KIKDNGDLVLSSPSN
S266 DNGDLVLSSPSNVTL
S267 NGDLVLSSPSNVTLP
S269 DLVLSSPSNVTLPQV
N270 LVLSSPSNVTLPQVK
T272 LSSPSNVTLPQVKTE
K277 NVTLPQVKTEKEDFI
K280 LPQVKTEKEDFIELC
T288 EDFIELCTPGVIKQE
K293 LCTPGVIKQEKLGTV
K296 PGVIKQEKLGTVYCQ
Y301 QEKLGTVYCQASFPG
S305 GTVYCQASFPGANII
P307 VYCQASFPGANIIGN
S317 NIIGNKMSAISVHGV
S390 FPGRTVFSNGYSSPS
S395 VFSNGYSSPSMRPDV
S404 SMRPDVSSPPSSSST
K419 ATTGPPPKLCLVCSD
K480 CPACRYRKCLQAGMN
K492 GMNLEARKTKKKIKG
K494 NLEARKTKKKIKGIQ
K495 LEARKTKKKIKGIQQ
K498 RKTKKKIKGIQQATT
S508 QQATTGVSQETSENP
K681 SVPKDGLKSQELFDE
K703 ELGKAIVKREGNSSQ
  mouse

 
S6 __MDSKESLAPPGRD
A8 MDSKESLAPPGRDEV
R24-m1 SSLLGRGrGSVMDLY
Y31 rGSVMDLYKTLrGGA
T33 SVMDLYKTLrGGATV
R35-m1 MDLYKTLrGGATVKV
T39 KTLrGGATVKVSASs
S45 ATVKVSASsPSVAAA
S46-p TVKVSASsPSVAAAS
A55 SVAAASQADSKQQRI
S57 AAASQADSKQQRILL
S88 QQPQPDLSKAVSLSM
Y98 VSLSMGLYMGETETK
T102 MGLYMGETETKVMGN
T104 LYMGETETKVMGNDL
S122-p QQGQLGLsSGETDFR
S134 DFRLLEESIANLNRS
S141 SIANLNRSTSRPENP
T142 IANLNRSTSRPENPK
S143 ANLNRSTSRPENPKs
S150-p SRPENPKsStPAAGC
T152-p PENPKsStPAAGCAt
T159-p tPAAGCAtPtEKEFP
T161-p AAGCAtPtEKEFPQT
K163 GCAtPtEKEFPQTHS
T168 tEKEFPQTHSDPSSE
S181-p SEQQNRKsQPGTNGG
S212-p DLEFSAGsPGKETNE
T217 AGsPGKETNEsPWRS
S220-p PGKETNEsPWRSDLL
S234-p LIDENLLsPLAGEDD
T268-p TKPKIQDtGDtILss
T271-p KIQDtGDtILssPss
S274-p DtGDtILssPssVAL
S275-p tGDtILssPssVALP
S277-p DtILssPssVALPQV
S278-p tILssPssVALPQVK
A280 LssPssVALPQVKTE
K285 sVALPQVKTEkDDFI
K288-ub LPQVKTEkDDFIELC
T296 DDFIELCTPGVIKQE
K301 LCTPGVIKQEKLGPV
K304 PGVIKQEKLGPVYCQ
Y309 QEKLGPVYCQASFsG
S313 GPVYCQASFsGTNII
S315-p VYCQASFsGTNIIGN
S325 NIIGNKMSAISVHGV
S398 FAGRSVFSNGYSSPG
S403 VFSNGYSSPGMRPDV
S412-p GMRPDVSsPPSSSST
K426-ub TATGPPPkLCLVCSD
K487 CPACRYRKCLQAGMN
K499 GMNLEARKTKKKIkG
K501 NLEARKTKKKIkGIQ
K502 LEARKTKKKIkGIQQ
K505-ub RKTKKKIkGIQQATA
S515 QQATAGVSQDTSENA
K687 SVPKEGLKSQELFDE
K709 ELGKAIVKREGNSSQ
4161 : Phospho-Glucocorticoid Receptor (Ser211) Antibody
  rat

 
S6 __MDSKESLAPPGRD
A8 MDSKESLAPPGRDEV
R24-m1 GSLLGQGrGSVMDFY
Y31 rGSVMDFYKSLRGGA
S33 SVMDFYKSLRGGATV
R35 MDFYKSLRGGATVKV
T39 KSLRGGATVKVSASS
S45 ATVKVSASSPSVAAA
S46 TVKVSASSPSVAAAS
A55 SVAAASQADSKQQRI
S57 AAASQADSKQQRILL
S100 QQQQPDLSKAVSLSM
Y110 VSLSMGLYMGETETK
T114 MGLYMGETETKVMGN
T116 LYMGETETKVMGNDL
S134 QQGQLGLSSGETDFR
S146 DFRLLEESIANLNRS
S153 SIANLNRSTsVPENP
T154 IANLNRSTsVPENPK
S155-p ANLNRSTsVPENPKS
S162 sVPENPKSSTSATGC
T164 PENPKSSTSATGCAt
T171-p TSATGCAtPTEKEFP
T173 ATGCAtPTEKEFPKt
K175 GCAtPTEKEFPKtHS
T180-p TEKEFPKtHSDASSE
S193 SEQQNRKSQTGTNGG
S224-p DLEFSAGsPSKDTNE
T229 AGsPSKDTNEsPWRS
S232-p PSKDTNEsPWRSDLL
S246-p LIDENLLsPLAGEDD
T280 TKPKIKDTGDTILss
T283 KIKDTGDTILssPSS
S286-p DTGDTILssPSSVAL
S287-p TGDTILssPSSVALP
S289 DTILssPSSVALPQV
S290 TILssPSSVALPQVk
A292 LssPSSVALPQVkTE
K297-sm SVALPQVkTEKDDFI
K300 LPQVkTEKDDFIELC
T308 DDFIELCTPGVIkQE
K313-sm LCTPGVIkQEKLGPV
K316 PGVIkQEKLGPVYCQ
Y321 QEKLGPVYCQASFSG
S325 GPVYCQASFSGTNII
S327 VYCQASFSGTNIIGN
S337 NIIGNKMSAISVHGV
S410 FPGRSVFSNGYSsPG
S415-p VFSNGYSsPGMRPDV
S424 GMRPDVSSPPSSSSA
K438 AATGPPPKLCLVCSD
K499 CPACRYRKCLQAGMN
K511 GMNLEARKTKKKIKG
K513 NLEARKTKKKIKGIQ
K514 LEARKTKKKIKGIQQ
K517 RKTKKKIKGIQQATA
S527-p QQATAGVsQDTSENP
K699 SVPKEGLKSQELFDE
K721-sm ELGKAIVkREGNSSQ
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