transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Mitochondrial; Nuclear receptor; Transcription factor
Molecular Function: protein homodimerization activity; zinc ion binding; Hsp70 protein binding; Hsp90 protein binding; receptor tyrosine kinase binding; steroid binding; glucocorticoid receptor activity; protein binding; protein heterodimerization activity; sequence-specific DNA binding; double-stranded DNA binding; chromatin binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; circadian rhythm; response to arsenic; positive regulation of glutamate secretion; signal transduction; response to insulin stimulus; response to mercury ion; response to radiation; chromatin-mediated maintenance of transcription; positive regulation of neuron apoptosis; response to corticosterone stimulus; aging; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; adrenal gland development; regulation of glucocorticoid biosynthetic process; muscle atrophy; regulation of cell proliferation; glucocorticoid metabolic process; negative regulation of vascular permeability; gene expression; regulation of gluconeogenesis; brain development; response to activity; negative regulation of transforming growth factor beta receptor signaling pathway; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.