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Protein Page:
IkB-beta (human)

Overview
IkB-beta a protein of the NF-kappa-B inhibitor family. Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA- dependent inactivation. Association with inhibitor kappa B- interacting Ras-like proteins 1 and 2 may also explain the slower degradation. Interacts with ligand-binding domain of thyroid hormone receptor-beta, inhibitor kappa B-interacting Ras-like protein 1, inhibitor kappa B-interacting protein Ras2, p65 (RELA) and c-Rel. Expressed in all tissues examined. Note: This description may include information from UniProtKB.
Protein type: Inhibitor protein
Cellular Component: cytosol; nucleus
Molecular Function: signal transducer activity; protein binding; transcription coactivator activity
Biological Process: transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; signal transduction; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon type I production; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  Q15653 (UniProtKB)
Alt. Names/Synonyms: I-kappa-B-beta; IkappaBbeta; IkB-B; IkB-beta; IKBB; NF-kappa-B inhibitor beta; NF-kappa-BIB; NFKBIB; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; Thyroid receptor-interacting protein 9; TR-interacting protein 9; TRIP-9; TRIP9
Gene Symbols: NFKBIB
Molecular weight: 37,771 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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IkB-beta

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S313‑p, S315‑p
transcription, inhibited: S313‑p, S315‑p
activity, induced: S313‑p, S315‑p
intracellular localization: S313‑p, S315‑p
protein degradation: S19‑p, S23‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
5 0 S19-p DADEWCDsGLGsLGP
5 0 S23-p WCDsGLGsLGPDAAA
0 1 - gap
0 1 - gap
1 1 Y161-p PREAPDTyLAQGPDR
0 2 S183-p PVALYPDsDLEKEEE
0 1 T239-p DLDKPEPtCGRSPLH
0 1 T276-p ARMYGGRtPLGsAML
0 1 S280-p GGRtPLGsAMLRPNP
0 1 S308-p PEGEDEKsGPCSsSs
3 0 S313-p EKsGPCSsSsDSDSG
3 0 S315-p sGPCSsSsDSDSGDE
0 5 T343 SQTRLPPTPASKPLP
4921 : Phospho-IkappaB-beta (Thr19/Ser23) Antibody (Human Specific)
4921 : Phospho-IkappaB-beta (Thr19/Ser23) Antibody (Human Specific)
  IkB-beta iso3  
- gap
- gap
S36-p RGCRGLPsSSATSLR
T46-p ATSLRMGtRFSAGTE
Y129 PREAADTYLAQGPDR
S151 PVALYPDSDLEKEEE
T207 DLDKPEPTCGRSPLH
T244 VRMYGGRTPLGSAML
S248 GGRTPLGSAMLRPNP
S276 PEGEDEKSGPCSSSS
S281 EKSGPCSSSSDSDSG
S283 SGPCSSSSDSDSGDE
- gap
  mouse

 
S19-p DADEWCDsGLGsLGP
S23-p WCDsGLGsLGPDAAA
- gap
- gap
Y161 PRDASDTYLTQSQDC
P183 PAAVDSQPNPENEEE
T239 DLNKPEPTCGRTPLH
T276 ARMYGGRTPLGSALL
S280 GGRTPLGSALLRPNP
L308 PEDEDDKLSPCSSSG
S313 DKLSPCSSSGSDSDS
S318 CSSSGSDSDSDNRDE
S346-p SQNRQPPsPASKPLP
  rat

 
S19-p DADEWCDsGLGsLGP
S23-p WCDsGLGsLGPDAAA
- gap
- gap
Y161-p PRDASDTyLTQSQDH
P183 PVATDPQPNPGNEEE
T239 DLNKPEPTCGRTPLH
T276 ARMYGGRTPLGSALL
S280 GGRTPLGSALLRPNP
L308 PEDKDDKLSPCSNSS
N313 DKLSPCSNSSSDSDS
S318 CSNSSSDSDSDNRDE
S346 SQNQPPPSPAAKPLP
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