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Protein Page:
GNAO1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GNAO1 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))
Cellular Component: extrinsic to internal side of plasma membrane; plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; signal transducer activity; GTP binding; mu-type opioid receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; metabotropic serotonin receptor binding
Biological Process: response to drug; negative regulation of calcium ion transport; response to morphine; locomotory behavior; regulation of heart contraction; G-protein signaling, coupled to cAMP nucleotide second messenger; response to hydrogen peroxide; muscle contraction; GTP catabolic process; response to cytokine stimulus; forebrain development; dopamine receptor signaling pathway; neurite development; aging; positive regulation of GTPase activity
Reference #:  P09471 (UniProtKB)
Alt. Names/Synonyms: DKFZp686O0962; G-ALPHA-o; GNAO; GNAO1; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha activating polypeptide O; Guanine nucleotide-binding protein G(o) subunit alpha
Gene Symbols: GNAO1
Molecular weight: 40,051 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
CST Pathways:  Phospholipase Signaling  |  PI3K/Akt Signaling  |  Regulation of Microtubule Dynamics  |  Signaling Pathways Activating p38 MAPK
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GNAO1
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 T4-p ____MGCtLsAEERA
0 1 S6-p __MGCtLsAEERAAL
0 16 K21-u ERSKAIEkNLkEDGI
0 19 K24-u KAIEkNLkEDGISAA
0 2 S29 NLkEDGISAAkDVkL
0 14 K32-u EDGISAAkDVkLLLL
0 2 K35-a ISAAkDVkLLLLGAG
0 6 K35-u ISAAkDVkLLLLGAG
0 47 K46-u LGAGESGkSTIVkQM
0 42 K51-u SGkSTIVkQMKIIHE
0 7 K54 STIVkQMKIIHEDGF
0 2 S62 IIHEDGFSGEDVkQy
0 12 K67-u GFSGEDVkQyKPVVy
0 6 Y69-p SGEDVkQyKPVVySN
0 15 K70 GEDVkQyKPVVySNT
0 8 Y74-p kQyKPVVySNTIQSL
0 6 Y95 MDTLGIEYGDkERKA
0 2 K98 LGIEYGDKERKADAk
0 21 K98-u LGIEYGDkERKADAk
0 7 K101 EYGDkERKADAkMVC
0 22 K105-u kERKADAkMVCDVVs
0 2 S112-p kMVCDVVsRMEDTEP
0 1 S126 PFSAELLSAMMRLWG
0 15 Y147-p CFNRSREyQLNDSAk
0 16 K154-u yQLNDSAkyyLDSLD
0 5 Y155-p QLNDSAkyyLDSLDR
0 6 Y156-p LNDSAkyyLDSLDRI
0 4 S159 SAkyyLDSLDRIGAA
0 8 Y168-p DRIGAADyQPTEQDI
0 6 K181 DILRTRVKTTGIVET
0 2 K193 VETHFTFKNLHFRLF
0 2 S207-p FDVGGQRsERKKWIH
0 1 M249 NRMHESLMLFDSICN
0 1 K278 KKDLFGEKIKKSPLt
0 1 T285-p KIKKSPLtICFPEyT
0 1 Y291-p LtICFPEyTGPNTYE
0 3 Y297 EyTGPNTYEDAAAYI
0 2 K311 IQAQFESKNRSPNKE
  mouse

► Hide Isoforms 		 
T4 ____MGCTLSAEERA
S6 __MGCTLSAEERAAL
K21-u ERSKAIEkNLkEDGI
K24-u KAIEkNLkEDGIsAA
S29-p NLkEDGIsAAkDVkL
K32-u EDGIsAAkDVkLLLL
K35 IsAAkDVKLLLLGAG
K35-u IsAAkDVkLLLLGAG
K46-u LGAGESGkSTIVkQM
K51-u SGkSTIVkQMkIIHE
K54-u STIVkQMkIIHEDGF
S62-p IIHEDGFsGEDVkQY
K67-u GFsGEDVkQYkPVVY
Y69 sGEDVkQYkPVVYSN
K70-u GEDVkQYkPVVYSNT
Y74 kQYkPVVYSNTIQSL
Y95 MDTLGVEYGDkERkT
K98 LGVEYGDKERkTDSk
K98-u LGVEYGDkERkTDSk
K101-u EYGDkERkTDSkMVC
K105-u kERkTDSkMVCDVVs
S112-p kMVCDVVsRMEDTEP
S126-p PFSAELLsAMMRLWG
Y147 CFNRSREYQLNDSAk
K154-u YQLNDSAkYYLDsLD
Y155 QLNDSAkYYLDsLDR
Y156 LNDSAkYYLDsLDRI
S159-p SAkYYLDsLDRIGAG
Y168 DRIGAGDYQPTEQDI
K181-u DILRTRVkTTGIVET
K193-u VETHFTFkNLHFRLF
S207-p FDVGGQRsERKKWIH
M249 NRMHESLMLFDSICN
K278-u KKDLFGEkIKKSPLT
T285 kIKKSPLTICFPEYP
Y291 LTICFPEYPGSNTYE
Y297 EYPGSNTYEDAAAYI
K311-u IQTQFESkNRSPNKE
  GNAO1 iso2  
T4 ____MGCTLSAEERA
S6 __MGCTLSAEERAAL
K21 ERSKAIEKNLKEDGI
K24 KAIEKNLKEDGISAA
S29 NLKEDGISAAKDVKL
K32 EDGISAAKDVKLLLL
K35 ISAAKDVKLLLLGAG
K35 ISAAKDVKLLLLGAG
K46 LGAGESGKSTIVKQM
K51 SGKSTIVKQMKIIHE
K54 STIVKQMKIIHEDGF
S62 IIHEDGFSGEDVKQY
K67 GFSGEDVKQYKPVVY
Y69 SGEDVKQYKPVVYSN
K70 GEDVKQYKPVVYSNT
Y74 KQYKPVVYSNTIQSL
Y95 MDTLGVEYGDKERKT
K98 LGVEYGDKERKTDSK
K98 LGVEYGDKERKTDSK
K101 EYGDKERKTDSKMVC
K105 KERKTDSKMVCDVVS
S112 KMVCDVVSRMEDTEP
S126 PFSAELLSAMMRLWG
Y147 CFNRSREYQLNDSAK
K154 YQLNDSAKYYLDSLD
Y155 QLNDSAKYYLDSLDR
Y156 LNDSAKYYLDSLDRI
S159 SAKYYLDSLDRIGAG
Y168 DRIGAGDYQPTEQDI
K181 DILRTRVKTTGIVET
K193 VETHFTFKNLHFRLF
S207 FDVGGQRSERKKWIH
K249-u NRMHESLkLFDSICN
K278 KKDIFEEKIKKSPLT
T285 KIKKSPLTICFPEYT
Y291 LTICFPEYTGPSAFT
F297 EYTGPSAFTEAVAHI
K311 IQGQYESKNKSAHKE
  rat

 
T4 ____MGCTLSAEERA
S6 __MGCTLSAEERAAL
K21-u ERSKAIEkNLkEDGI
K24-u KAIEkNLkEDGISAA
S29 NLkEDGISAAkDVkL
K32-u EDGISAAkDVkLLLL
K35-a ISAAkDVkLLLLGAG
K35-u ISAAkDVkLLLLGAG
K46-u LGAGESGkSTIVkQM
K51-u SGkSTIVkQMKIIHE
K54 STIVkQMKIIHEDGF
S62 IIHEDGFSGEDVkQy
K67-u GFSGEDVkQykPVVy
Y69-p SGEDVkQykPVVySN
K70-u GEDVkQykPVVySNT
Y74-p kQykPVVySNTIQSL
Y95-p MDTLGVEyGDkERkA
K98-a LGVEyGDkERkADSk
K98-u LGVEyGDkERkADSk
K101-u EyGDkERkADSkMVC
K105-u kERkADSkMVCDVVS
S112 kMVCDVVSRMEDTEP
S126 PFSAELLSAMMRLWG
Y147-p CFNRSREyQLNDSAk
K154-u yQLNDSAkyyLDSLD
Y155-p QLNDSAkyyLDSLDR
Y156-p LNDSAkyyLDSLDRI
S159 SAkyyLDSLDRIGAA
Y168-p DRIGAADyQPTEQDI
K181 DILRTRVKTTGIVET
K193 VETHFTFKNLHFRLF
S207 FDVGGQRSERKKWIH
M249 NRMHESLMLFDSICN
K278 KKDLFGEKIKKSPLT
T285 KIKKSPLTICFPEYP
Y291 LTICFPEYPGSNTyE
Y297-p EYPGSNTyEDAAAYI
K311 IQTQFESKNRSPNKE
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