Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric
Cellular Component: neuron projection; extrinsic to internal side of plasma membrane; plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; corticotropin-releasing hormone receptor 1 binding; signal transducer activity; GTP binding; mu-type opioid receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding
Biological Process: response to drug; negative regulation of calcium ion transport; response to morphine; locomotory behavior; regulation of heart contraction; G-protein signaling, coupled to cAMP nucleotide second messenger; response to hydrogen peroxide; muscle contraction; response to cytokine stimulus; forebrain development; dopamine receptor signaling pathway; neurite development; aging; positive regulation of GTPase activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.