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Protein Page:
G-alpha(o) (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
G-alpha(o) Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. Interacts with RGS14. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric; G protein
Cellular Component: neuron projection; extrinsic to internal side of plasma membrane; plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; corticotropin-releasing hormone receptor 1 binding; signal transducer activity; GTP binding; mu-type opioid receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activating protein binding; metabotropic serotonin receptor binding
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to drug; negative regulation of calcium ion transport; muscle contraction; response to hydrogen peroxide; GTP catabolic process; response to cytokine stimulus; forebrain development; dopamine receptor signaling pathway; response to morphine; locomotory behavior; neurite development; regulation of heart contraction; aging; positive regulation of GTPase activity
Reference #:  P09471 (UniProtKB)
Alt. Names/Synonyms: DKFZp686O0962; G-ALPHA-o; GNAO; GNAO1; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; guanine nucleotide binding protein, alpha activating polypeptide O; Guanine nucleotide-binding protein G(o) subunit alpha
Gene Symbols: GNAO1
Molecular weight: 40,051 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

G-alpha(o)

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T4-p ____MGCtLsAEERA
0 1 S6-p __MGCtLsAEERAAL
0 16 K21 ERSKAIEKNLKEDGI
0 19 K24 KAIEKNLKEDGISAA
0 2 S29 NLKEDGISAAKDVKL
0 14 K32 EDGISAAKDVKLLLL
0 2 K35 ISAAKDVKLLLLGAG
0 6 K35 ISAAKDVKLLLLGAG
0 2 S44-p LLLGAGEsGkSTIVk
0 47 K46-ub LGAGEsGkSTIVkQM
0 42 K51-ub sGkSTIVkQMKIIHE
0 7 K54 STIVkQMKIIHEDGF
0 2 S62 IIHEDGFSGEDVKQY
0 12 K67 GFSGEDVKQYKPVVY
0 6 Y69 SGEDVKQYKPVVYSN
0 15 K70 GEDVKQYKPVVYSNT
0 5 Y74 KQYKPVVYSNTIQSL
0 1 S75 QYKPVVYSNTIQSLA
0 6 Y95 MDTLGIEYGDKERKA
0 2 K98 LGIEYGDKERKADAK
0 21 K98 LGIEYGDKERKADAK
0 7 K101 EYGDKERKADAKMVC
0 22 K105 KERKADAKMVCDVVs
0 2 S112-p KMVCDVVsRMEDTEP
0 1 S126 PFSAELLSAMMRLWG
0 2 S144 IQECFNRSREyQLND
0 14 Y147-p CFNRSREyQLNDSAK
0 16 K154 yQLNDSAKYYLDSLD
0 5 Y155 QLNDSAKYYLDSLDR
0 6 Y156 LNDSAKYYLDSLDRI
0 5 S159 SAKYYLDSLDRIGAA
0 8 Y168 DRIGAADYQPTEQDI
0 6 K181 DILRTRVKtTGIVEt
0 1 T182-p ILRTRVKtTGIVEtH
0 1 T188-p KtTGIVEtHFtFKNL
0 1 T191-p GIVEtHFtFKNLHFR
0 2 K193 VEtHFtFKNLHFRLF
0 2 S207-p FDVGGQRsERKKWIH
0 1 M249 NRMHESLMLFDsICN
0 2 S253-p ESLMLFDsICNNKFF
0 1 K278 KKDLFGEKIKKSPLt
0 1 T285-p KIKKSPLtICFPEyT
0 1 Y291-p LtICFPEyTGPNTYE
0 1 Y297 EyTGPNTYEDAAAYI
0 2 K311 IQAQFESKNRSPNKE
  mouse

► Hide Isoforms
 
T4 ____MGCTLSAEERA
S6 __MGCTLSAEERAAL
K21-ub ERSKAIEkNLkEDGI
K24-ub KAIEkNLkEDGIsAA
S29-p NLkEDGIsAAkDVkL
K32-ub EDGIsAAkDVkLLLL
K35 IsAAkDVKLLLLGAG
K35-ub IsAAkDVkLLLLGAG
S44-p LLLGAGEsGkSTIVk
K46-ub LGAGEsGkSTIVkQM
K51-ub sGkSTIVkQMkIIHE
K54-ub STIVkQMkIIHEDGF
S62-p IIHEDGFsGEDVkQY
K67-ub GFsGEDVkQYkPVVY
Y69 sGEDVkQYkPVVYSN
K70-ub GEDVkQYkPVVYSNT
Y74 kQYkPVVYSNTIQSL
S75 QYkPVVYSNTIQSLA
Y95 MDTLGVEYGDkERkT
K98 LGVEYGDKERkTDSk
K98-ub LGVEYGDkERkTDSk
K101-ub EYGDkERkTDSkMVC
K105-ub kERkTDSkMVCDVVs
S112-p kMVCDVVsRMEDTEP
S126-p PFSAELLsAMMRLWG
S144 IQECFNRSREYQLND
Y147 CFNRSREYQLNDSAk
K154-ub YQLNDSAkYYLDsLD
Y155 QLNDSAkYYLDsLDR
Y156 LNDSAkYYLDsLDRI
S159-p SAkYYLDsLDRIGAG
Y168 DRIGAGDYQPTEQDI
K181-ub DILRTRVkTTGIVET
T182 ILRTRVkTTGIVETH
T188 kTTGIVETHFTFkNL
T191 GIVETHFTFkNLHFR
K193-ub VETHFTFkNLHFRLF
S207-p FDVGGQRsERKKWIH
M249 NRMHESLMLFDsICN
S253-p ESLMLFDsICNNKFF
K278-ub KKDLFGEkIKKSPLT
T285 kIKKSPLTICFPEYP
Y291 LTICFPEYPGSNTYE
Y297 EYPGSNTYEDAAAYI
K311-ub IQTQFESkNRSPNKE
  G-alpha(o) iso2  
T4 ____MGCTLSAEERA
S6 __MGCTLSAEERAAL
K21 ERSKAIEKNLKEDGI
K24 KAIEKNLKEDGISAA
S29 NLKEDGISAAKDVKL
K32 EDGISAAKDVKLLLL
K35 ISAAKDVKLLLLGAG
K35 ISAAKDVKLLLLGAG
S44 LLLGAGESGKSTIVK
K46 LGAGESGKSTIVKQM
K51 SGKSTIVKQMKIIHE
K54 STIVKQMKIIHEDGF
S62 IIHEDGFSGEDVKQY
K67 GFSGEDVKQYKPVVY
Y69 SGEDVKQYKPVVYSN
K70 GEDVKQYKPVVYSNT
Y74 KQYKPVVYSNTIQSL
S75 QYKPVVYSNTIQSLA
Y95 MDTLGVEYGDKERKT
K98 LGVEYGDKERKTDSK
K98 LGVEYGDKERKTDSK
K101 EYGDKERKTDSKMVC
K105 KERKTDSKMVCDVVS
S112 KMVCDVVSRMEDTEP
S126 PFSAELLSAMMRLWG
S144 IQECFNRSREYQLND
Y147 CFNRSREYQLNDSAK
K154 YQLNDSAKYYLDSLD
Y155 QLNDSAKYYLDSLDR
Y156 LNDSAKYYLDSLDRI
S159 SAKYYLDSLDRIGAG
Y168 DRIGAGDYQPTEQDI
K181 DILRTRVKTTGIVET
T182 ILRTRVKTTGIVETH
T188 KTTGIVETHFTFKNL
T191 GIVETHFTFKNLHFR
K193 VETHFTFKNLHFRLF
S207 FDVGGQRSERKKWIH
K249-ub NRMHESLkLFDSICN
S253 ESLkLFDSICNNKWF
K278 KKDIFEEKIKKSPLT
T285 KIKKSPLTICFPEYT
Y291 LTICFPEYTGPSAFT
F297 EYTGPSAFTEAVAHI
K311 IQGQYESKNKSAHKE
  rat

 
T4 ____MGCTLSAEERA
S6 __MGCTLSAEERAAL
K21-ub ERSKAIEkNLkEDGI
K24-ub KAIEkNLkEDGISAA
S29 NLkEDGISAAkDVkL
K32-ub EDGISAAkDVkLLLL
K35-ac ISAAkDVkLLLLGAG
K35-ub ISAAkDVkLLLLGAG
S44 LLLGAGESGkSTIVk
K46-ub LGAGESGkSTIVkQM
K51-ub SGkSTIVkQMKIIHE
K54 STIVkQMKIIHEDGF
S62 IIHEDGFSGEDVkQy
K67-ub GFSGEDVkQykPVVy
Y69-p SGEDVkQykPVVysN
K70-ub GEDVkQykPVVysNT
Y74-p kQykPVVysNTIQSL
S75-p QykPVVysNTIQSLA
Y95-p MDTLGVEyGDkERkA
K98-ac LGVEyGDkERkADSk
K98-ub LGVEyGDkERkADSk
K101-ub EyGDkERkADSkMVC
K105-ub kERkADSkMVCDVVS
S112 kMVCDVVSRMEDTEP
S126 PFSAELLSAMMRLWG
S144-p IQECFNRsREyQLND
Y147-p CFNRsREyQLNDSAk
K154-ub yQLNDSAkyyLDsLD
Y155-p QLNDSAkyyLDsLDR
Y156-p LNDSAkyyLDsLDRI
S159-p SAkyyLDsLDRIGAA
Y168-p DRIGAADyQPTEQDI
K181 DILRTRVKTTGIVET
T182 ILRTRVKTTGIVETH
T188 KTTGIVETHFTFKNL
T191 GIVETHFTFKNLHFR
K193 VETHFTFKNLHFRLF
S207 FDVGGQRSERKKWIH
M249 NRMHESLMLFDSICN
S253 ESLMLFDSICNNKFF
K278 KKDLFGEKIKKSPLT
T285 KIKKSPLTICFPEYP
Y291 LTICFPEYPGSNTyE
Y297-p EYPGSNTyEDAAAYI
K311 IQTQFESKNRSPNKE
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