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Protein Page:
PTPRA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTPRA a receptor protein tyrosine phosphatase (PTP). Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. Dephosphorylates and activates Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Four alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; Membrane protein, integral
Cellular Component: integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: axon guidance; insulin receptor signaling pathway; protein amino acid phosphorylation
Reference #:  P18433 (UniProtKB)
Alt. Names/Synonyms: HEPTP; HLPR; HPTPA; HPTPalpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); LRP; protein tyrosine phosphatase, receptor type, A; protein tyrosine phosphatase, receptor type, alpha polypeptide; Protein-tyrosine phosphatase alpha; PTPA; PTPase-alpha; PTPLCA-related phosphatase; PTPRA; PTPRL2; R-PTP-alpha; Receptor-type tyrosine-protein phosphatase alpha; RPTPA; tyrosine phosphatase alpha
Gene Symbols: PTPRA
Molecular weight: 90,600 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Select Structure to View Below

PTPRA

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: Y798‑p
enzymatic activity, induced: Y798‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S18-p GSGLICVsANNATTV
0 1 S185 SNSKQAGSHSNsFRL
6 6 S189-p QAGSHSNsFRLSNGR
0 1 S204 TEDVEPQSVPLLARs
0 6 S211-p SVPLLARsPstNRKy
6 3 S213-p PLLARsPstNRKyPP
0 2 T214-p LLARsPstNRKyPPL
0 2 Y218-p sPstNRKyPPLPVDK
0 28 Y271-p ENKEKNRyVNILPYD
0 1 S293-p PVEGVPDsDYINASF
0 1 K307 FINGYQEKNKFIAAQ
0 1 S407-p ITQFHFTsWPDFGVP
0 1 Y522-p ETHLQKIyNKIPGTS
0 1 S542-p EEFKKLTsIKIQNDK
0 1 T552-p IQNDKMRtGNLPANM
0 1 Y588-p RGEENTDyVNASFID
0 1 K765-ac LDVFQTVksLRLQRP
0 1 S766-p DVFQTVksLRLQRPH
1 0 Y781 MVQTLEQYEFCYKVV
1 0 Y785 LEQYEFCYKVVQEyI
1 1 Y791-p CYKVVQEyIDAFsDy
0 12 S796-p QEyIDAFsDyANFK_
14 2346 Y798-p yIDAFsDyANFK___
4481 : Phospho-PTP alpha (Tyr789) Antibody
  PTPRA iso2  
S18 GSGLICVSANNATTV
S176 SNSKQAGSHSNsFRL
S180-p QAGSHSNsFRLSNGR
S195 TEDVEPQSVPLLARS
S202 SVPLLARSPsTNRKY
S204-p PLLARSPsTNRKYPP
T205 LLARSPsTNRKYPPL
Y209 SPsTNRKYPPLPVDK
Y262 ENKEKNRYVNILPYD
S284 PVEGVPDSDYINASF
K298 FINGYQEKNKFIAAQ
S398 ITQFHFTSWPDFGVP
Y513 ETHLQKIYNKIPGTS
S533 EEFKKLTSIKIQNDK
T543 IQNDKMRTGNLPANM
Y579 RGEENTDYVNASFID
K756 LDVFQTVKSLRLQRP
S757 DVFQTVKSLRLQRPH
Y772-p MVQTLEQyEFCyKVV
Y776-p LEQyEFCyKVVQEyI
Y782-p CyKVVQEyIDAFSDy
S787 QEyIDAFSDyANFK_
Y789-p yIDAFSDyANFK___
4481 : Phospho-PTP alpha (Tyr789) Antibody
  mouse

 
S18 GSGLIHVSANNATTV
S176-p KKYKQAGsHSNsFRL
S180-p QAGsHSNsFRLSNGR
S195-p TEDVEPQsVPLLARs
S202-p sVPLLARsPstNRKY
S204-p PLLARsPstNRKYPP
T205-p LLARsPstNRKYPPL
Y209 sPstNRKYPPLPVDK
Y262 ENKEKNRYVNILPFL
S320 PVEGVPDSDYINASF
K334-ub FINGYQEkNKFIAAQ
S434 ITQFHFTSWPDFGVP
Y549 ETHLQKIYNKIPGTS
S569 EEFKKLTSIKIQNDK
T579 IQNDKMRTGNLPANM
Y615 RGEENTDYVNASFID
K792 LDVFQTVKSLRLQRP
S793 DVFQTVKSLRLQRPH
Y808 MVQTLEQYEFCYKVV
Y812 LEQYEFCYKVVQEYI
Y818 CYKVVQEYIDAFsDy
S823-p QEYIDAFsDyANFK_
Y825-p YIDAFsDyANFK___
4481 : Phospho-PTP alpha (Tyr789) Antibody
  rat

 
S18 GSGLIHISANNTTTV
S179 KKYKQAGSHSNsFRL
S183-p QAGSHSNsFRLSNGR
S198 TEDVEPQSVPLLARS
S205 SVPLLARSPSTNRKY
S207 PLLARSPSTNRKYPP
T208 LLARSPSTNRKYPPL
Y212 SPSTNRKYPPLPVDK
Y265-p ENKEKNRyVNLLPYD
S287 PVEGVPDSDYINASF
K301 FINGYQEKNKFIAAQ
S401 ITQFHFTSWPDFGVP
Y516 DTHLQKIYNKIPGTS
S536 EEFKKLTSIKIQNDK
T546 IQNDKMRTGYLPANM
Y582 RGEENTDYVNASFID
K759 LDVFQTVKTLRLQRP
T760 DVFQTVKTLRLQRPH
Y775 MVQILEQYEFCYKVV
Y779 LEQYEFCYKVVQEYI
Y785 CYKVVQEYIDAFSDy
S790 QEYIDAFSDyANFK_
Y792-p YIDAFSDyANFK___
4481 : Phospho-PTP alpha (Tyr789) Antibody
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