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PTPRA (human)

Overview PTPRA a receptor protein tyrosine phosphatase (PTP). Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. Dephosphorylates and activates Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Four alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; EC 3.1.3.48; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine Cellular Component: integral to plasma membrane; plasma membrane Molecular Function: transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity Biological Process: axon guidance; insulin receptor signaling pathway; protein amino acid phosphorylation Reference #:  P18433 (UniProtKB) Alt. Names/Synonyms: HEPTP; HLPR; HPTPA; HPTPalpha; Leukocyte common antigen-related peptide (protein tyrosine phosphate); LRP; protein tyrosine phosphatase, receptor type, A; protein tyrosine phosphatase, receptor type, alpha polypeptide; Protein-tyrosine phosphatase alpha; PTPA; PTPase-alpha; PTPLCA-related phosphatase; PTPRA; PTPRL2; R-PTP-alpha; Receptor-type tyrosine-protein phosphatase alpha; RPTPA; tyrosine phosphatase alpha Gene Symbols: PTPRA Molecular weight: 90,600 Da Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states

Select Structure to View Below PTPRA 1P15 - A/B=577-829 (mouse) 1YFO - A/B=202-539 (mouse)

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	Sites Implicated In
cytoskeletal reorganization: Y798‑p enzymatic activity, induced: Y798‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S18-p	GSGLICVsANNATTV
0	1		S185	SNSKQAGSHSNsFRL
6	5		S189-p	QAGSHSNsFRLSNGR
0	1		S204	TEDVEPQSVPLLARs
0	4		S211-p	SVPLLARsPstNRKy
6	1		S213-p	PLLARsPstNRKyPP
0	1		T214-p	LLARsPstNRKyPPL
0	2		Y218-p	sPstNRKyPPLPVDK
0	13		Y271-p	ENKEKNRyVNILPYD
0	1		K307	FINGYQEKNKFIAAQ
0	1		S407-p	ITQFHFTsWPDFGVP
0	1		S542-p	EEFKKLTsIKIQNDK
0	1		T552-p	IQNDKMRtGNLPANM
0	1		Y588-p	RGEENTDyVNASFID
0	1		K765-a	LDVFQTVksLRLQRP
0	1		S766-p	DVFQTVksLRLQRPH
1	1		Y781-p	MVQTLEQyEFCYKVV
1	0		Y785	LEQyEFCYKVVQEyI
1	1		Y791-p	CYKVVQEyIDAFsDy
0	7		S796-p	QEyIDAFsDyANFK_
14	2329		Y798-p	yIDAFsDyANFK___

	PTPRA iso2
S18	GSGLICVSANNATTV
S176	SNSKQAGSHSNsFRL
S180-p	QAGSHSNsFRLSNGR
S195	TEDVEPQSVPLLARS
S202	SVPLLARSPsTNRKY
S204-p	PLLARSPsTNRKYPP
T205	LLARSPsTNRKYPPL
Y209	SPsTNRKYPPLPVDK
Y262	ENKEKNRYVNILPYD
K298	FINGYQEKNKFIAAQ
S398	ITQFHFTSWPDFGVP
S533	EEFKKLTSIKIQNDK
T543	IQNDKMRTGNLPANM
Y579	RGEENTDYVNASFID
K756	LDVFQTVKSLRLQRP
S757	DVFQTVKSLRLQRPH
Y772-p	MVQTLEQyEFCyKVV
Y776-p	LEQyEFCyKVVQEyI
Y782-p	CyKVVQEyIDAFSDy
S787	QEyIDAFSDyANFK_
Y789-p	yIDAFSDyANFK___

	mouse
S18	GSGLIHVSANNATTV
S176-p	KKYKQAGsHSNsFRL
S180-p	QAGsHSNsFRLSNGR
S195-p	TEDVEPQsVPLLARs
S202-p	sVPLLARsPsTNRKY
S204-p	PLLARsPsTNRKYPP
T205	LLARsPsTNRKYPPL
Y209	sPsTNRKYPPLPVDK
Y262	ENKEKNRYVNILPFL
K334-u	FINGYQEkNKFIAAQ
S434	ITQFHFTSWPDFGVP
S569	EEFKKLTSIKIQNDK
T579	IQNDKMRTGNLPANM
Y615	RGEENTDYVNASFID
K792	LDVFQTVKSLRLQRP
S793	DVFQTVKSLRLQRPH
Y808	MVQTLEQYEFCYKVV
Y812	LEQYEFCYKVVQEYI
Y818	CYKVVQEYIDAFSDy
S823	QEYIDAFSDyANFK_
Y825-p	YIDAFSDyANFK___

	rat
S18	GSGLIHISANNTTTV
S179	KKYKQAGSHSNSFRL
S183	QAGSHSNSFRLSNGR
S198	TEDVEPQSVPLLARS
S205	SVPLLARSPSTNRKY
S207	PLLARSPSTNRKYPP
T208	LLARSPSTNRKYPPL
Y212	SPSTNRKYPPLPVDK
Y265-p	ENKEKNRyVNLLPYD
K301	FINGYQEKNKFIAAQ
S401	ITQFHFTSWPDFGVP
S536	EEFKKLTSIKIQNDK
T546	IQNDKMRTGYLPANM
Y582	RGEENTDYVNASFID
K759	LDVFQTVKTLRLQRP
T760	DVFQTVKTLRLQRPH
Y775	MVQILEQYEFCYKVV
Y779	LEQYEFCYKVVQEYI
Y785	CYKVVQEYIDAFSDy
S790	QEYIDAFSDyANFK_
Y792-p	YIDAFSDyANFK___

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