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Protein Page:
SUFU (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SUFU a transcriptional regulator which negatively regulates the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. Modulates nuclear-cytoplasmic shuttling of Gli-1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of FUSED to both SUFU and a GLI protein. Mutations in SUFU predispose to medulloblastoma. Part of a DNA-bound corepressor complex containing SAP18, GLI1 and SIN3. Part of a complex containing CTNNB1. Binds BTRC, GLI2, GLI3, SAP18 and STK36. Binds both free and DNA-bound GLI1. Defects in SUFU are a cause of medulloblastoma (MDB). MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Transcription, coactivator/corepressor
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; signal transducer activity; beta-catenin binding; transcription factor binding; transcription corepressor activity; protein kinase binding
Biological Process: skin development; cytoplasmic sequestering of transcription factor; multicellular organismal development; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription factor import into nucleus; proteolysis; signal transduction; regulation of transcription, DNA-dependent; negative regulation of smoothened signaling pathway; neural tube closure; negative regulation of osteoblast differentiation; heart looping; skeletal development; smoothened signaling pathway involved in ventral spinal cord interneuron specification; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
Reference #:  Q9UMX1 (UniProtKB)
Alt. Names/Synonyms: PRO1280; SUFU; SUFUH; SUFUXL; Suppressor of fused homolog; suppressor of fused homolog (Drosophila)
Gene Symbols: SUFU
Molecular weight: 53,947 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SUFU

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S342‑p, S346‑p
phosphorylation: S346‑p
protein stabilization: S342‑p, S346‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T13-p PSGAPGPtAPPAPGP
0 1 T21-p APPAPGPtAPPAFAS
0 1 T190 PQMQPVQTPFGVVTF
1 1 K257-ub HLQERVDkGIETDGS
0 1 S267 ETDGSNLSGVSAKCA
0 1 S290-p EDDEDSRsICIGTQP
0 4 S301-p GTQPRRLsGkDtEQI
0 1 K303-ac QPRRLsGkDtEQIRE
0 2 T305-p RRLsGkDtEQIRETL
0 2 K321-ub RGLEINSkPVLPPIN
1 7 S342-p LAHDRAPsRKDsLEs
1 17 S346-p RAPsRKDsLEsDSSt
0 5 S349-p sRKDsLEsDSStAII
0 1 S352 DsLEsDSStAIIPHE
0 2 T353-p sLEsDSStAIIPHEL
0 4 K457-ub LTSPEEFkLPKEYSW
0 1 S481-p LPDVVFDsPLH____
  mouse

 
A13 PSVAPGPAAPPASGP
S21 APPASGPSAPPAFAS
T190-p PQMQPVRtPFGVVTF
K257 HLQERVDKGIETDGS
S267-p ETDGSNLsGVSAKCA
S290 EDEEDSRSICLGTQP
S301-p GTQPRRLsGKDTEQI
K303 QPRRLsGKDTEQIRE
T305 RRLsGKDTEQIRETL
K321 RGLEINSKPVLPPIN
S342-p LTHDRAPsRKDsLGs
S346-p RAPsRKDsLGsDSst
S349-p sRKDsLGsDSstAII
S352-p DsLGsDSstAIIPHE
T353-p sLGsDSstAIIPHEL
K457-ub LTSPEEFkLPKEYSW
S481 LPDVVFDSPLH____
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