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Protein Page:
SPG20 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SPG20 May be implicated in endosomal trafficking, or microtubule dynamics, or both. Defects in SPG20 are the cause of spastic paraplegia autosomal recessive type 20 (SPG20); also known as Troyer syndrome (TRS). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG20 is characterized by dysarthria, distal amyotrophy, mild developmental delay and short stature. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: mitochondrial outer membrane; cytoplasm; plasma membrane; lipid particle; synapse; midbody
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: cell death; regulation of mitochondrial membrane potential; negative regulation of collateral sprouting in the absence of injury; cell division; neuromuscular process; abscission; negative regulation of BMP signaling pathway
Reference #:  Q8N0X7 (UniProtKB)
Alt. Names/Synonyms: KIAA0610; Spartin; spastic paraplegia 20 (Troyer syndrome); Spastic paraplegia 20 protein; SPG20; TAHCCP1; Trans-activated by hepatitis C virus core protein 1
Gene Symbols: SPG20
Molecular weight: 72,833 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SPG20

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K29-ub KAFLFVNkGLNTDEL
0 10 Y45-p QKEEAKNyykQGIGH
0 5 Y46-p KEEAKNyykQGIGHL
0 2 K47-ub EEAKNyykQGIGHLL
0 1 K62-ub RGISISSkESEHTGP
0 2 K82-ub RQMQQKMkETLQNVR
0 1 S102 LEKGLATSLQNDLQE
0 6 L126 PKDMCEKLPEPQSFS
0 4 K287-ub PDRSPVLkCTAGAYM
0 2 S357-p IPGRTRPssDQLkEA
0 5 S358-p PGRTRPssDQLkEAS
0 59 K362-ub RPssDQLkEASGTDV
0 1 K362-m1 RPssDQLkEASGTDV
0 30 K370-ub EASGTDVkQLDQGNk
0 1 K370-m1 EASGTDVkQLDQGNk
0 8 K377-ub kQLDQGNkDVRHkGK
0 1 K382-m1 GNkDVRHkGKRGKRA
0 2 K390-ub GKRGKRAkDTSSEEV
0 2 K414 PVPEEKPKELPEWSE
0 1 K422-ub ELPEWSEkVAHNILS
0 16 K440-ub WVSWGLVkGAEITGk
0 5 K447-ub kGAEITGkAIQKGAS
0 11 K465-ub ERIQPEEkPVEVsPA
0 5 S470-p EEkPVEVsPAVTkGL
0 1 T474 VEVsPAVTkGLYIAk
0 17 K475-ub EVsPAVTkGLYIAkQ
0 16 K481-ub TkGLYIAkQATGGAA
0 1 K489-ac QATGGAAkVSQFLVD
0 5 K489-ub QATGGAAkVSQFLVD
0 10 K507-ub TVANCVGkELAPHVk
0 2 K514-ub kELAPHVkKHGSkLV
0 3 K519-ub HVkKHGSkLVPEsLK
0 1 S524-p GSkLVPEsLKKDkDG
0 1 K526 kLVPEsLKKDkDGkS
0 3 K529-ub PEsLKKDkDGkSPLD
0 3 K532-ub LKKDkDGkSPLDGAM
0 1 K578-ub TVQTVRYkYGYNAGE
0 2 T618 AMVKKTATQTGHTLL
0 15 Y628-p GHTLLEDyQIVDNSQ
  mouse

► Hide Isoforms
 
K29 KAFMFVNKGLNTDEL
Y45 QKEEAKNYYkQGIGH
Y46 KEEAKNYYkQGIGHL
K47-ub EEAKNYYkQGIGHLL
A62 RGISIAAAEPGHTGP
K82-ub RQMQQKMkETLQNVR
S102-p LEKGLATsLRNDLQD
S126-p PKDACKKsPEQESVS
K287-ub PDRSPVLkCTVGAYM
P355 IPGRSSHPSEPPkEA
S356 PGRSSHPSEPPkEAS
K360-ub SHPSEPPkEASGTDV
K360 SHPSEPPKEASGTDV
R368 EASGTDVRQSSSSGS
R368 EASGTDVRQSSSSGS
K382-ub SSIDQGSkDARHKGK
K387 GSkDARHKGKRGKKT
K395-ub GKRGKKTkDSSEEVN
K418-ub PSSEEKSkELPEWSE
K426 ELPEWSEKVAHNILS
K444-ub WVSWGLVkGAEFTGk
K451-ub kGAEFTGkAIQKGAS
K469-ub ERIQPEEkPVEVSPA
S474 EEkPVEVSPAVtRGL
T478-gl VEVSPAVtRGLYIAk
R479 EVSPAVtRGLYIAkQ
K485-ub tRGLYIAkQATGGAA
K493 QATGGAAKVSQLLVD
K493-ub QATGGAAkVSQLLVD
K511-ub TVANCVGkELAPHVK
K518 kELAPHVKKHGSKLV
K523 HVKKHGSKLVPESLk
S528 GSKLVPESLkRDkDG
K530-ub KLVPESLkRDkDGKS
K533-ub PESLkRDkDGKSALD
K536 LkRDkDGKSALDGAM
K582 TVQTVRYKYGHNAGE
K622-ub AMVKKTAkQTGHTLL
Y632 GHTLLEDYQIVERPQ
  SPG20 iso2  
K29 KAFMFVNKGLNTDEL
Y45 QKEEAKNYYKQGIGH
Y46 KEEAKNYYKQGIGHL
K47 EEAKNYYKQGIGHLL
A62 RGISIAAAEPGHTGP
K82 RQMQQKMKETLQNVR
S102 LEKGLATSLRNDLQD
S126 PKDACKKSPEQESVS
K287 PDRSPVLKCTVGAYM
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K338-ub SDLRLQTkDSSEEVN
K361 PSSEEKSKELPEWSE
K369 ELPEWSEKVAHNILS
K387 WVSWGLVKGAEFTGK
K394 KGAEFTGKAIQKGAS
K412 ERIQPEEKPVEVSPA
S417 EEKPVEVSPAVTRGL
T421 VEVSPAVTRGLYIAK
R422 EVSPAVTRGLYIAKQ
K428 TRGLYIAKQATGGAA
K436 QATGGAAKVSQLLVD
K436 QATGGAAKVSQLLVD
K454 TVANCVGKELAPHVK
K461 KELAPHVKKHGSKLV
K466 HVKKHGSKLVPESLK
S471 GSKLVPESLKRDKDG
K473 KLVPESLKRDKDGKS
K476 PESLKRDKDGKSALD
K479 LKRDKDGKSALDGAM
K525 TVQTVRYKYGHNAGE
K565 AMVKKTAKQTGHTLL
Y575 GHTLLEDYQIVERPQ
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K66 FQIPGRVKELPKEAS
K70 GRVKELPKEASGTDV
K70 GRVKELPKEASGTDV
R78 EASGTDVRQSSSSGS
R78 EASGTDVRQSSSSGS
K92 SSIDQGSKDARHKGK
K97 GSKDARHKGKRGKKT
K105 GKRGKKTKDSSSEEV
K129 PSSEEKSKDLPEWSE
K137 DLPEWSEKVAHNILS
K155 WVSWGLVKGAEFTGK
K162 KGAEFTGKAIQKGAS
K180-ub ERIQPEEkPVEVSPA
S185 EEkPVEVSPAVTRGL
T189 VEVSPAVTRGLYIAK
R190 EVSPAVTRGLYIAKQ
K196 TRGLYIAKQATGGAA
K204 QATGGAAKVSQFLVD
K204 QATGGAAKVSQFLVD
K222 TVANCVGKELAPHVK
K229 KELAPHVKKHGSKLV
K234 HVKKHGSKLVPESLK
S239 GSKLVPESLKRDKDG
K241 KLVPESLKRDKDGKS
K244 PESLKRDKDGKSTLD
K247 LKRDKDGKSTLDGAM
K293 TVQTVRYKYGHNAGE
K333 AMVKKTAKQTGHTLL
Y343 GHTLLEDYQIIESPQ
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