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PLB (human)

Overview PLB a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Inhibitor protein Cellular Component: protein complex; sarcoplasmic reticulum; mitochondrial membrane; integral to membrane; vesicle Molecular Function: protein binding; ATPase inhibitor activity; calcium channel regulator activity Biological Process: cardiac muscle development; cellular calcium ion homeostasis; negative regulation of heart contraction; blood circulation; calcium ion transport; regulation of calcium ion transport; regulation of the force of heart contraction Reference #:  P26678 (UniProtKB) Alt. Names/Synonyms: Cardiac phospholamban; CMD1P; phospholamban; PLB; PLN; PPLA Gene Symbols: PLN Molecular weight: 6,109 Da Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PLB 1K9N - A/B/C/D/E=35-52 (human) 1KCH - A/B/C/D/E=35-52 (human) 1PLN - A/B/C/D/E=35-52 (human) 1PLP - A=1-24 (human) 1PSL - A/B/C/D/E=1-52 (human) 1ZLL - A/B/C/D/E=1-52 (human) 2HYN - A/B/C/D/E=1-52 (human) 3O7L - I=4-18 (mouse) 1N7L - A=1-52 (rabbit) 2LPF - A=1-52 (rabbit) 1FJK - A=1-52 (pig) 1FJP - A=1-52 (pig)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN  |  Phospho3D  |  DISEASE 172405 609909  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
activation: S16‑p molecular association, regulation: S16‑p, T17‑p protein conformation: S16‑p, T17‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K3	_____MEKVQYLTRS
38	61		S16-p	RSAIRRAstIEMPQQ
2	0		S16	RSAIRRAStIEMPQQ
40	57		T17-p	SAIRRAstIEMPQQA

	mouse
K3-u	_____MEkVQYLTRS
S16-p	RSAIRRAstIEMPQQ
S16-g	RSAIRRAstIEMPQQ
T17-p	SAIRRAstIEMPQQA

	rat
K3	_____MEKVQYLTRS
S16-p	RSAIRRAstIEMPQQ
S16-g	RSAIRRAstIEMPQQ
T17-p	SAIRRAstIEMPQQA

	rabbit
K3	_____MEKVQYLTRS
S16-p	RSAIRRAstIEMPQQ
S16	RSAIRRAStIEMPQQ
T17-p	SAIRRAstIEMPQQA

	pig
K3	_____MDKVQYLTRS
S16-p	RSAIRRAsTIEMPQQ
S16	RSAIRRASTIEMPQQ
T17	SAIRRAsTIEMPQQA

	dog
K3	_____MDKVQYLTRS
S16-p	RSAIRRAstIEMPQQ
S16	RSAIRRAStIEMPQQ
T17-p	SAIRRAstIEMPQQA

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