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Protein Page:
PLB (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PLB a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Inhibitor protein
Chromosomal Location of Human Ortholog: 6q22.1
Cellular Component: sarcoplasmic reticulum membrane; mitochondrion; membrane; perinuclear region of cytoplasm; endoplasmic reticulum; mitochondrial membrane; vesicle
Molecular Function: enzyme inhibitor activity; identical protein binding; protein binding; ATPase inhibitor activity; calcium channel regulator activity; ATPase binding
Biological Process: cardiac muscle development; negative regulation of calcium ion transport; negative regulation of heart rate; cytosolic calcium ion homeostasis; blood circulation; regulation of calcium ion transport; response to testosterone stimulus; regulation of heart contraction; response to zinc ion; calcium ion transport; negative regulation of catalytic activity; negative regulation of ATPase activity; protein homooligomerization; regulation of the force of heart contraction
Reference #:  P26678 (UniProtKB)
Alt. Names/Synonyms: Cardiac phospholamban; CMD1P; phospholamban; PLB; PLN; PPLA
Gene Symbols: PLN
Molecular weight: 6,109 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PLB

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S16‑p
molecular association, regulation: S16‑p, T17‑p
protein conformation: S16‑p, T17‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3 _____MEKVQYLTRS
46 63 S16-p RSAIRRAstIEMPQQ
2 0 S16 RSAIRRAStIEMPQQ
51 59 T17-p SAIRRAstIEMPQQA
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
  mouse

 
K3-ub _____MEkVQYLTRS
S16-p RSAIRRAstIEMPQQ
S16-gl RSAIRRAstIEMPQQ
T17-p SAIRRAstIEMPQQA
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
  rat

 
K3 _____MEKVQYLTRS
S16-p RSAIRRAstIEMPQQ
S16-gl RSAIRRAstIEMPQQ
T17-p SAIRRAstIEMPQQA
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
  rabbit

 
K3 _____MEKVQYLTRS
S16-p RSAIRRAstIEMPQQ
S16 RSAIRRAStIEMPQQ
T17-p SAIRRAstIEMPQQA
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
  pig

 
K3 _____MDKVQYLTRS
S16-p RSAIRRAsTIEMPQQ
S16 RSAIRRASTIEMPQQ
T17 SAIRRAsTIEMPQQA
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
  dog

 
K3 _____MDKVQYLTRS
S16-p RSAIRRAstIEMPQQ
S16 RSAIRRAStIEMPQQ
T17-p SAIRRAstIEMPQQA
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
8496 : Phospho-Phospholamban (Ser16/Thr17) Antibody
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