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Protein Page:
RNF25 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RNF25 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase; Transcription, coactivator/corepressor
Cellular Component: cytosol; nucleus
Molecular Function: NF-kappaB binding; protein binding; zinc ion binding; metal ion binding; ubiquitin-protein ligase activity; ligase activity
Biological Process: protein ubiquitination; activation of NF-kappaB transcription factor
Reference #:  Q9QZR0 (UniProtKB)
Alt. Names/Synonyms: 0610009H16Rik; AO7; E3 ubiquitin-protein ligase RNF25; OTTMUSP00000024323; RING finger protein 25; RING finger protein AO7; Rnf25
Gene Symbols: Rnf25
Molecular weight: 51,227 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Select Structure to View Below

RNF25

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 S89 IRNPRGLSDEQIHKI
0 4 K119-u MLYELIEkGKEILTD
0 5 K331-u QRPGETQkSVLDPPR
0 3 R338 kSVLDPPRHGRGSWR
0 1 K353-u QYDRRHPkGGECCTP
0 1 K361-u GGECCTPkGTSEIHE
0 1 K383 LKETVDLKAEPRNKG
0 1 K398-u LTGHPQEkGPGSWQG
0 1 S402 PQEkGPGSWQGPSAR
0 2 Y429 NRTPGSCYPHLPrGQ
0 3 R434-m1 SCYPHLPrGQGAYRS
0 9 P447 RSGTRREPLGLESEE
0 2 E453 EPLGLESEEGS____
  human

 
S90-p IRNPRGLsDEQIHTI
K120-u MLYELIEkGKEILTD
K334-u QRLGETQkAMLDPPk
K341-u kAMLDPPkPSRGPWR
K356 QPERRHPKGGECHAP
K364 GGECHAPKGTRDTQE
K386-u LKEPMDLkPEPHSQG
K401 VEGPPQEKGPGsWQG
S405-p PQEKGPGsWQGPPPR
Y432-p GRTPGSSyPRLPrGQ
R437-m1 SSyPRLPrGQGAYRP
S450-p RPGTRREsLGLESkD
K456-u EsLGLESkDGS____
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