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Protein Page:
SLC25A15 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC25A15 Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix. Defects in SLC25A15 are the cause of hyperornithinemia- hyperammonemia-homocitrullinuria syndrome (HHH syndrome). It is an autosomal recessive disorder resulting in various neurologic symptoms, including mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma caused by hyperammonemia. It causes a functional impairment of the urea cycle. Belongs to the mitochondrial carrier family. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Mitochondrial
Cellular Component: mitochondrial inner membrane; integral to membrane
Molecular Function: L-ornithine transmembrane transporter activity
Biological Process: amino acid metabolic process; mitochondrial ornithine transport; urea cycle
Reference #:  Q9Y619 (UniProtKB)
Alt. Names/Synonyms: D13S327; HHH; Mitochondrial ornithine transporter 1; ORC1; ornithine transporter 1; ornithine transporter) member 15; ORNT1; SLC25A15; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 15
Gene Symbols: SLC25A15
Molecular weight: 32,736 Da
Basal Isoelectric point: 9.28  Predict pI for various phosphorylation states
Select Structure to View Below

SLC25A15

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K2 ______MKSNPAIQA
0 1 K34 GQPFDTMKVKMQTFP
0 1 K36 PFDTMKVKMQTFPDL
0 1 K36 PFDTMKVKMQTFPDL
0 1 T152-p KIAKSQNtVWSVIKS
0 1 K158 NtVWSVIKSILRKDG
0 2 K245-ub QVLSMSGkQAGFIRT
0 1 K245 QVLSMSGKQAGFIRT
  mouse

 
K2-ub ______MkSNPAIQA
K34 GQPFDTMKVkMQTFP
K36-ub PFDTMKVkMQTFPDL
K36-sc PFDTMKVkMQTFPDL
T152 KIAASQNTVWSVVkE
K158-ac NTVWSVVkEIFRKDG
K245-ub QVLSMTGkQTGLVRT
K245-sc QVLSMTGkQTGLVRT
  rat

 
K2-ub ______MkSNPAIQA
K34-ub GQPFDTMkVKMQTFP
K36 PFDTMkVKMQTFPDL
K36 PFDTMkVKMQTFPDL
T152 KIAASQNTVWSVVKE
K158 NTVWSVVKEIFRKDG
K245 QVLSMTGKQTGLIRT
K245 QVLSMTGKQTGLIRT
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