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Protein Page:
pumilio 1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
pumilio 1 Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells. Strongly down-regulated in keratinocytes upon ultraviolet B radiation. Binds in a sequence-specific manner to the 3'-UTR of some mRNAs. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Translation
Cellular Component: cytosol
Molecular Function: RNA binding
Biological Process: regulation of translation; post-Golgi vesicle-mediated transport; membrane organization and biogenesis
Reference #:  Q14671 (UniProtKB)
Alt. Names/Synonyms: HsPUM; KIAA0099; PUM1; PUMH; PUMH1; Pumilio homolog 1; pumilio homolog 1 (Drosophila); Pumilio-1; PUML1
Gene Symbols: PUM1
Molecular weight: 126,473 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

pumilio 1
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 3 S19-p VLWQDSFsPHLKHHP
0 4 S75-p SIGVAGRsQDDAMVD
0 274 Y83-p QDDAMVDyFFQRQHG
0 3 S98-p EQLGGGGsGGGGYNN
0 2 S106-p GGGGYNNsKHRWPtG
0 494 T112-p NsKHRWPtGDNIHAE
0 14 S124-p HAEHQVRsMDELNHD
0 2 S197-p VQRRPGQsFHVNSEV
0 1 S206-p HVNSEVNsVLsPRSE
0 10 S209-p SEVNsVLsPRSESGG
0 1 S212 NsVLsPRSESGGLGV
0 2 S228-p MVEYVLSssPGDSCL
0 4 S229-p VEYVLSssPGDSCLR
0 1 K270-u GDKLGDLkEEGDVMD
0 7 T514-p GASQRPLtPNQNQQG
0 223 S709-p GSGSRRDsLtGssDL
0 12 T711-p GSRRDsLtGssDLyk
0 4 S713-p RRDsLtGssDLykRT
0 3 S714-p RDsLtGssDLykRTS
0 45 Y717-p LtGssDLykRTSSSL
0 2 K718-u tGssDLykRTSSSLT
0 19 K794-u AAPGAEAkYRsASSA
0 1 S797-p GAEAkYRsASSASSL
0 5 S806-p SSASSLFsPsstLFS
0 2 S808-p ASSLFsPsstLFSsS
0 1 S809-p SSLFsPsstLFSsSR
0 1 T810-p SLFsPsstLFSsSRL
0 2 S814-p PsstLFSsSRLRYGM
0 1 K914-u EFGSLEQkLALAERI
0 1 K940 YGCRVIQKALEFIPS
0 2 K963-u ELDGHVLkCVkDQNG
0 3 K966-u GHVLkCVkDQNGNHV
0 1 K1058-a EHGRPEDkSKIVAEI
0 6 K1084-u FASNVVEkCVTHASR
0 1 T1103 VLIDEVCTMNDGPHS
0 1 S1110 TMNDGPHSALyTMMK
0 3 Y1113-p DGPHSALyTMMKDQy
0 1 T1114 GPHSALyTMMKDQyA
0 1 Y1120-p yTMMKDQyANyVVQk
0 6 Y1123-p MKDQyANyVVQkMID
0 1 K1127-u yANyVVQkMIDVAEP
0 7 T1150-p KIRPHIAtLRKyTYG
0 2 Y1154-p HIAtLRKyTYGKHIL
0 1 Y1167 ILAKLEKYyMKNGVD
0 2 Y1168-p LAKLEKYyMKNGVDL
  pumilio 1 iso2  
S19 VLWQDSFSPHLKHHP
S75 SIGVAGRSQDDAMVD
Y83 QDDAMVDYFFQRQHG
S98 EQLGGGGSGGGGYNN
S106 GGGGYNNSKHRWPTG
T112 NSKHRWPTGDNIHAE
S124 HAEHQVRSMDELNHD
S197 VQRRPGQSFHVNSEV
S206 HVNSEVNSVLSPRSE
S209 SEVNSVLSPRSESGG
S212 NSVLSPRSESGGLGV
S228 MVEYVLSSSPGDSCL
S229 VEYVLSSSPGDSCLR
K270 GDKLGDLKEEGDVMD
T515 GASQRPLTPNQNQQG
S683 GSGSRRDSLTGSSDL
T685 GSRRDSLTGSSDLYK
S687 RRDSLTGSSDLYKRT
S688 RDSLTGSSDLYKRTS
Y691 LTGSSDLYKRTSSSL
K692 TGSSDLYKRTSSSLT
K768 AAPGAEAKYRSASSA
S771 GAEAKYRSASSASSL
S780 SSASSLFSPSSTLFS
S782 ASSLFSPSSTLFSSS
S783 SSLFSPSSTLFSSSR
T784 SLFSPSSTLFSSSRL
S788 PSSTLFSSSRLRYGM
K888 EFGSLEQKLALAERI
K914-u YGCRVIQkALEFIPS
K939 ELDGHVLKCVKDQNG
K942 GHVLKCVKDQNGNHV
K1034 EHGRPEDKSKIVAEI
K1060 FASNVVEKCVTHASR
T1079 VLIDEVCTMNDGPHS
S1086 TMNDGPHSALYTMMK
Y1089 DGPHSALYTMMKDQY
T1090 GPHSALYTMMKDQYA
Y1096 YTMMKDQYANYVVQK
Y1099 MKDQYANYVVQKMID
K1103 YANYVVQKMIDVAEP
T1126 KIRPHIATLRKYTYG
Y1130 HIATLRKYTYGKHIL
Y1143 ILAKLEKYYMKNGVD
Y1144 LAKLEKYYMKNGVDL
  mouse

 
S19 VLWQDSFSPHLKHHP
S75-p SIGVAGRsQDDAMVD
Y83-p QDDAMVDyFFQRQHG
S98 EQLGGGGSGGGGYNT
S106 GGGGYNTSKHRWPtG
T112-p TSKHRWPtGDNIHAE
S124-p HAEHQVRsMDELNHD
S197 VQRRPGQSFHVNSEV
S206 HVNSEVNSVLsPRsE
S209-p SEVNSVLsPRsESGG
S212-p NSVLsPRsESGGLGV
S228-p MVEYVLSssPGDSCL
S229-p VEYVLSssPGDSCLR
K270 GDKLGDLKEEGDVMD
T515 GASQRPLTPNQNQQG
S710-p GSGSRRDsLtGSSDL
T712-p GSRRDsLtGSSDLYK
S714 RRDsLtGSSDLYKRT
S715 RDsLtGSSDLYKRTS
Y718 LtGSSDLYKRTSSSL
K719 tGSSDLYKRTSSSLA
K795-u AAPGAEAkYRSASSA
S798 GAEAkYRSASSASSL
S807-p SSASSLFsPSSTLFS
S809 ASSLFsPSSTLFSSS
S810 SSLFsPSSTLFSSSR
T811 SLFsPSSTLFSSSRL
S815 PSSTLFSSSRLRYGM
K915 EFGSHEQKLALAERI
K941 YGCRVIQKALEFIPS
K966 ELDGHVLKCVkDQNG
K969-u GHVLKCVkDQNGNHV
K1061 EHGRPEDKSKIVAEI
K1087 FASNVVEKCVTHASR
T1106-p VLIDEVCtMNDGPHs
S1113-p tMNDGPHsALytMMK
Y1116-p DGPHsALytMMKDQY
T1117-p GPHsALytMMKDQYA
Y1123 ytMMKDQYANYVVQK
Y1126 MKDQYANYVVQKMID
K1130 YANYVVQKMIDVAEP
T1153 KIRPHIATLRKYTYG
Y1157 HIATLRKYTYGKHIL
Y1170 ILAKLEKYYMKNGVD
Y1171 LAKLEKYYMKNGVDL
  rat

 
S19 VLWQDSFSPHLKHHP
S75 SIGVAGRSQDDAMVD
Y83 QDDAMVDYFFQRQHG
S98 EQLGGGGSGGGGYNT
S106 GGGGYNTSKHRWPTG
T112 TSKHRWPTGDNIHAE
S124 HAEHQVRSMDELNHD
S197 VQRRPGQSFHVNSEV
S206 HVNSEVNSVLSPRSE
S209 SEVNSVLSPRSESGG
S212 NSVLSPRSESGGLGV
S228 MVEYVLSSSPGDSCL
S229 VEYVLSSSPGDSCLR
K270 GDKLGDLKEEGDVMD
T515 GASQRPLTPNQNQQG
S710-p GSGSRRDsLTGSSDL
T712 GSRRDsLTGSSDLYK
S714 RRDsLTGSSDLYKRT
S715 RDsLTGSSDLYKRTS
Y718 LTGSSDLYKRTSSSL
K719 TGSSDLYKRTSSSLA
K795 AAPGAEAKYRSASSA
S798 GAEAKYRSASSASSL
S807 SSASSLFSPSSTLFS
S809 ASSLFSPSSTLFSSS
S810 SSLFSPSSTLFSSSR
T811 SLFSPSSTLFSSSRL
S815 PSSTLFSSSRLRYGM
K915 EFGSHEQKLALAERI
K941 YGCRVIQKALEFIPS
K966 ELDGHVLKCVKDQNG
K969 GHVLKCVKDQNGNHV
K1061 EHGRPEDKSKIVAEI
K1087 FASNVVEKCVTHASR
T1106 VLIDEVCTMNDGPHS
S1113 TMNDGPHSALYTMMK
Y1116 DGPHSALYTMMKDQY
T1117 GPHSALYTMMKDQYA
Y1123 YTMMKDQYANYVVQK
Y1126 MKDQYANYVVQKMID
K1130 YANYVVQKMIDVAEP
T1153 KIRPHIATLRKyTYG
Y1157-p HIATLRKyTYGKHIL
Y1170-p ILAKLEKyyMKNGVD
Y1171-p LAKLEKyyMKNGVDL
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