Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Pumilio-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Pumilio-1 Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells. Strongly down-regulated in keratinocytes upon ultraviolet B radiation. Binds in a sequence-specific manner to the 3'-UTR of some mRNAs. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Translation
Chromosomal Location of Human Ortholog: 1p35.2
Cellular Component: cytosol
Biological Process: regulation of translation; post-Golgi vesicle-mediated transport
Reference #:  Q14671 (UniProtKB)
Alt. Names/Synonyms: HsPUM; KIAA0099; PUM1; PUMH; PUMH1; Pumilio homolog 1; pumilio homolog 1 (Drosophila); Pumilio-1; PUML1
Gene Symbols: PUM1
Molecular weight: 126,473 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Pumilio-1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 S17-p KAVLWQDsFsPHLKH
0 6 S19-p VLWQDsFsPHLKHHP
0 6 S75-p SIGVAGRsQDDAMVD
0 252 Y83-p QDDAMVDyFFQRQHG
0 5 S98-p EQLGGGGsGGGGYNN
0 3 S106-p GGGGYNNsKHRWPtG
0 529 T112-p NsKHRWPtGDNIHAE
0 23 S124-p HAEHQVRsMDELNHD
0 1 S159-p FWETDESsKDGPKGI
0 4 S197-p VQRRPGQsFHVNsEV
0 1 S202-p GQsFHVNsEVNsVLs
0 3 S206-p HVNsEVNsVLsPRSE
0 15 S209-p sEVNsVLsPRSEsGG
0 1 S212 NsVLsPRSEsGGLGV
0 1 S214-p VLsPRSEsGGLGVsM
0 1 S220-p EsGGLGVsMVEyVLS
0 2 Y224-p LGVsMVEyVLSssPG
0 2 S228-p MVEyVLSssPGDsCL
0 7 S229-p VEyVLSssPGDsCLR
0 1 S233-p LSssPGDsCLRKGGF
0 1 S247-p FGPRDADsDENDKGE
0 1 K270-ub GDKLGDLkEEGDVMD
0 7 T514-p GASQRPLtPNQNQQG
0 269 S709-p GSGSRRDsLtGssDL
0 13 T711-p GSRRDsLtGssDLyk
0 5 S713-p RRDsLtGssDLykRT
0 3 S714-p RDsLtGssDLykRTS
0 49 Y717-p LtGssDLykRTSSSL
0 2 K718-ub tGssDLykRTSSSLT
0 19 K794-ub AAPGAEAkYrsAsSA
0 1 R796-m1 PGAEAkYrsAsSASs
0 1 S797-p GAEAkYrsAsSASsL
0 2 S799-p EAkYrsAsSASsLFs
0 1 S800 AkYrsAsSASsLFsP
0 2 S803-p rsAsSASsLFsPssT
0 8 S806-p sSASsLFsPssTLFs
0 2 S808-p ASsLFsPssTLFsss
0 2 S809-p SsLFsPssTLFsssR
0 1 S813-p sPssTLFsssRLRYG
0 2 S814-p PssTLFsssRLRYGM
0 1 S815-p ssTLFsssRLRYGMs
0 1 R818 LFsssRLRYGMsDVM
0 1 S822-p sRLRYGMsDVMPSGR
0 1 K914-ub EFGSLEQkLALAERI
0 1 K940 YGCRVIQKALEFIPS
0 2 K963-ub ELDGHVLkCVkDQNG
0 3 K966-ub GHVLkCVkDQNGNHV
0 1 K1058-ac EHGRPEDkSKIVAEI
0 6 K1084-ub FASNVVEkCVTHASR
0 1 T1103 VLIDEVCTMNDGPHS
0 1 S1110 TMNDGPHSALyTMMK
0 3 Y1113-p DGPHSALyTMMKDQy
0 1 T1114 GPHSALyTMMKDQyA
0 1 Y1120-p yTMMKDQyANyVVQk
0 6 Y1123-p MKDQyANyVVQkMID
0 1 K1127-ub yANyVVQkMIDVAEP
0 8 T1150-p KIRPHIAtLRKyTYG
0 1 Y1154-p HIAtLRKyTYGKHIL
0 1 Y1168-p LAKLEKYyMKNGVDL
  Pumilio-1 iso2  
S17 KAVLWQDSFSPHLKH
S19 VLWQDSFSPHLKHHP
S75 SIGVAGRSQDDAMVD
Y83 QDDAMVDYFFQRQHG
S98 EQLGGGGSGGGGYNN
S106 GGGGYNNSKHRWPTG
T112 NSKHRWPTGDNIHAE
S124 HAEHQVRSMDELNHD
S159 FWETDESSKDGPKGI
S197 VQRRPGQSFHVNSEV
S202 GQSFHVNSEVNSVLS
S206 HVNSEVNSVLSPRSE
S209 SEVNSVLSPRSESGG
S212 NSVLSPRSESGGLGV
S214 VLSPRSESGGLGVSM
S220 ESGGLGVSMVEYVLS
Y224 LGVSMVEYVLSSSPG
S228 MVEYVLSSSPGDSCL
S229 VEYVLSSSPGDSCLR
S233 LSSSPGDSCLRKGGF
S247 FGPRDADSDENDKGE
K270 GDKLGDLKEEGDVMD
T515 GASQRPLTPNQNQQG
S683 GSGSRRDSLTGSSDL
T685 GSRRDSLTGSSDLYK
S687 RRDSLTGSSDLYKRT
S688 RDSLTGSSDLYKRTS
Y691 LTGSSDLYKRTSSSL
K692 TGSSDLYKRTSSSLT
K768 AAPGAEAKYRSASSA
R770 PGAEAKYRSASSASS
S771 GAEAKYRSASSASSL
S773 EAKYRSASSASSLFS
S774 AKYRSASSASSLFSP
S777 RSASSASSLFSPSST
S780 SSASSLFSPSSTLFS
S782 ASSLFSPSSTLFSSS
S783 SSLFSPSSTLFSSSR
S787 SPSSTLFSSSRLRYG
S788 PSSTLFSSSRLRYGM
S789 SSTLFSSSRLRYGMS
R792 LFSSSRLRYGMSDVM
S796 SRLRYGMSDVMPSGR
K888 EFGSLEQKLALAERI
K914-ub YGCRVIQkALEFIPS
K939 ELDGHVLKCVKDQNG
K942 GHVLKCVKDQNGNHV
K1034 EHGRPEDKSKIVAEI
K1060 FASNVVEKCVTHASR
T1079 VLIDEVCTMNDGPHS
S1086 TMNDGPHSALYTMMK
Y1089 DGPHSALYTMMKDQY
T1090 GPHSALYTMMKDQYA
Y1096 YTMMKDQYANYVVQK
Y1099 MKDQYANYVVQKMID
K1103 YANYVVQKMIDVAEP
T1126 KIRPHIATLRKYTYG
Y1130 HIATLRKYTYGKHIL
Y1144 LAKLEKYYMKNGVDL
  Pumilio-1 iso4  
S53 KAVLWQDSFSPHLKH
S55 VLWQDSFSPHLKHHP
S111 SIGVAGRSQDDAMVD
Y119 QDDAMVDYFFQRQHG
S134 EQLGGGGSGGGGYNN
S142 GGGGYNNSKHRWPTG
T148 NSKHRWPTGDNIHAE
S160 HAEHQVRSMDELNHD
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S187-p EGPRDADsDENDKGE
K210 GDKLGDLKEEGDVMD
T455 GASQRPLTPNQNQQG
S650 GSGSRRDSLTGSSDL
T652 GSRRDSLTGSSDLYK
S654 RRDSLTGSSDLYKRT
S655 RDSLTGSSDLYKRTS
Y658 LTGSSDLYKRTSSSL
K659 TGSSDLYKRTSSSLT
K735 AAPGAEAKYRSASSA
R737 PGAEAKYRSASSASS
S738 GAEAKYRSASSASSL
S740 EAKYRSASSASSLFS
S741 AKYRSASSASSLFSP
S744 RSASSASSLFSPSST
S747 SSASSLFSPSSTLFS
S749 ASSLFSPSSTLFSSS
S750 SSLFSPSSTLFSSSR
S754 SPSSTLFSSSRLRYG
S755 PSSTLFSSSRLRYGM
S756 SSTLFSSSRLRYGMS
R759 LFSSSRLRYGMSDVM
S763 SRLRYGMSDVMPSGR
K855 EFGSLEQKLALAERI
K881 YGCRVIQKALEFIPS
K904 ELDGHVLKCVKDQNG
K907 GHVLKCVKDQNGNHV
K999 EHGRPEDKSKIVAEI
K1025 FASNVVEKCVTHASR
T1044 VLIDEVCTMNDGPHS
S1051 TMNDGPHSALYTMMK
Y1054 DGPHSALYTMMKDQY
T1055 GPHSALYTMMKDQYA
Y1061 YTMMKDQYANYVVQK
Y1064 MKDQYANYVVQKMID
K1068 YANYVVQKMIDVAEP
T1091 KIRPHIATLRKYTYG
Y1095 HIATLRKYTYGKHIL
Y1109 LAKLEKYYMKNGVDL
  mouse

 
S17 KAVLWQDSFSPHLKH
S19 VLWQDSFSPHLKHHP
S75-p SIGVAGRsQDDAMVD
Y83-p QDDAMVDyFFQRQHG
S98 EQLGGGGSGGGGYNT
S106 GGGGYNTSKHRWPtG
T112-p TSKHRWPtGDNIHAE
S124-p HAEHQVRsMDELNHD
S159 FWETDESSKDGPKGI
S197 VQRRPGQSFHVNSEV
S202 GQSFHVNSEVNSVLs
S206 HVNSEVNSVLsPRsE
S209-p SEVNSVLsPRsESGG
S212-p NSVLsPRsESGGLGV
S214 VLsPRsESGGLGVSM
S220 ESGGLGVSMVEyVLS
Y224-p LGVSMVEyVLSssPG
S228-p MVEyVLSssPGDSCL
S229-p VEyVLSssPGDSCLR
S233 LSssPGDSCLRKGGF
S247 FGPRDADSDENDKGE
K270 GDKLGDLKEEGDVMD
T515 GASQRPLTPNQNQQG
S710-p GSGSRRDsLtGsSDL
T712-p GSRRDsLtGsSDLYK
S714-p RRDsLtGsSDLYKRT
S715 RDsLtGsSDLYKRTS
Y718 LtGsSDLYKRTSSSL
K719 tGsSDLYKRTSSSLA
K795-ub AAPGAEAkYRSAssA
R797 PGAEAkYRSAssASS
S798 GAEAkYRSAssASSL
S800-p EAkYRSAssASSLFs
S801-p AkYRSAssASSLFsP
S804 RSAssASSLFsPsST
S807-p ssASSLFsPsSTLFS
S809-p ASSLFsPsSTLFSSS
S810 SSLFsPsSTLFSSSR
S814 sPsSTLFSSSRLrYG
S815 PsSTLFSSSRLrYGM
S816 sSTLFSSSRLrYGMS
R819-m2 LFSSSRLrYGMSDVM
S823 SRLrYGMSDVMPSGR
K915 EFGSHEQKLALAERI
K941 YGCRVIQKALEFIPS
K966 ELDGHVLKCVkDQNG
K969-ub GHVLKCVkDQNGNHV
K1061 EHGRPEDKSKIVAEI
K1087 FASNVVEKCVTHASR
T1106-p VLIDEVCtMNDGPHs
S1113-p tMNDGPHsALytMMK
Y1116-p DGPHsALytMMKDQY
T1117-p GPHsALytMMKDQYA
Y1123 ytMMKDQYANYVVQK
Y1126 MKDQYANYVVQKMID
K1130 YANYVVQKMIDVAEP
T1153 KIRPHIATLRKYTYG
Y1157 HIATLRKYTYGKHIL
Y1171 LAKLEKYYMKNGVDL
  rat

 
S17 KAVLWQDSFSPHLKH
S19 VLWQDSFSPHLKHHP
S75 SIGVAGRSQDDAMVD
Y83 QDDAMVDYFFQRQHG
S98 EQLGGGGSGGGGYNT
S106 GGGGYNTSKHRWPtG
T112-p TSKHRWPtGDNIHAE
S124-p HAEHQVRsMDELNHD
S159 FWETDESSKDGPKGI
S197 VQRRPGQSFHVNSEV
S202 GQSFHVNSEVNSVLS
S206 HVNSEVNSVLSPRSE
S209 SEVNSVLSPRSESGG
S212 NSVLSPRSESGGLGV
S214 VLSPRSESGGLGVSM
S220 ESGGLGVSMVEYVLS
Y224 LGVSMVEYVLSSSPG
S228 MVEYVLSSSPGDSCL
S229 VEYVLSSSPGDSCLR
S233 LSSSPGDSCLRKGGF
S247 FGPRDADSDENDKGE
K270 GDKLGDLKEEGDVMD
T515 GASQRPLTPNQNQQG
S710-p GSGSRRDsLTGSSDL
T712 GSRRDsLTGSSDLYK
S714 RRDsLTGSSDLYKRT
S715 RDsLTGSSDLYKRTS
Y718 LTGSSDLYKRTSSSL
K719 TGSSDLYKRTSSSLA
K795 AAPGAEAKYRSASSA
R797 PGAEAKYRSASSASS
S798 GAEAKYRSASSASSL
S800 EAKYRSASSASSLFS
S801 AKYRSASSASSLFSP
S804 RSASSASSLFSPSST
S807 SSASSLFSPSSTLFS
S809 ASSLFSPSSTLFSSS
S810 SSLFSPSSTLFSSSR
S814 SPSSTLFSSSRLRYG
S815 PSSTLFSSSRLRYGM
S816 SSTLFSSSRLRYGMS
R819 LFSSSRLRYGMSDVM
S823 SRLRYGMSDVMPSGR
K915 EFGSHEQKLALAERI
K941 YGCRVIQKALEFIPS
K966 ELDGHVLKCVKDQNG
K969 GHVLKCVKDQNGNHV
K1061 EHGRPEDKSKIVAEI
K1087 FASNVVEKCVTHASR
T1106 VLIDEVCTMNDGPHS
S1113 TMNDGPHSALYTMMK
Y1116 DGPHSALYTMMKDQY
T1117 GPHSALYTMMKDQYA
Y1123 YTMMKDQYANYVVQK
Y1126 MKDQYANYVVQKMID
K1130 YANYVVQKMIDVAEP
T1153 KIRPHIATLRKYTYG
Y1157 HIATLRKYTYGKHIL
Y1171 LAKLEKYYMKNGVDL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.