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Protein Page:
SLC37A4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC37A4 Transports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6- phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. Defects in SLC37A4 are the cause of glycogen storage disease type 1B (GSD1B). GSD1B is a metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. GSD1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease. Defects in SLC37A4 are the cause of glycogen storage disease type 1C (GSD1C). Defects in SLC37A4 are the cause of glycogen storage disease type 1D (GSD1D). Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter
Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; integral to endoplasmic reticulum membrane
Molecular Function: transporter activity; glucose-6-phosphate transmembrane transporter activity
Biological Process: glucose-6-phosphate transport; transport; hexose transport; carbohydrate metabolic process; glucose metabolic process; glucose transport; glucose homeostasis; transmembrane transport
Reference #:  O43826 (UniProtKB)
Alt. Names/Synonyms: G6PT; G6PT1; G6PT2; G6PT3; Glucose-5-phosphate transporter; glucose-6-phosphatase, transport (glucose) protein 3; glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1; glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2; Glucose-6-phosphate translocase; GSD1b; GSD1c; GSD1d; MGC15729; microsomal glucose-6-phosphate transporter; PRO0685; SLC37A4; solute carrier family 37 (glucose-6-phosphate transporter), member 4; solute carrier family 37 (glycerol-6-phosphate transporter), member 4; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19; TRG19
Gene Symbols: SLC37A4
Molecular weight: 46,360 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Select Structure to View Below

SLC37A4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T143-p TWWAILStsMNLAGG
0 1 S144-p WWAILStsMNLAGGL
0 1 E205 NLDPMPSEGkKGSLK
0 1 K207-ub DPMPSEGkKGSLKEE
0 1 K290-ub LSDRAMAkAGLSNYG
  mouse

 
T143 TWWAVLSTSMNLAGS
S144 WWAVLSTSMNLAGSL
K205-ub NLDPAPSkGKKGSSK
K207 DPAPSkGKKGSSKEE
K290 LSDRAMAKAGLSLYG
  rat

 
T143 TWWAVLSTSMNLAGS
S144 WWAVLSTSMNLAGSL
K205 NLDPAPSKGKKGSSK
K207 DPAPSKGKKGSSKEE
K290 LSDRAMAKAGLSVYG
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