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Protein Page:
MYH14 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MYH14 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). High levels of expression are found in small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor protein
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: growth cone; membrane; myosin II complex; axon; cytoplasm; stress fiber; actomyosin
Molecular Function: microfilament motor activity; actin filament binding; calmodulin binding; actin-dependent ATPase activity; ATP binding
Biological Process: ATP catabolic process; skeletal muscle contraction; regulation of cell shape; axon guidance; skeletal muscle development; sensory perception of sound; actin filament-based movement; actomyosin structure organization and biogenesis; generation of action potential; ephrin receptor signaling pathway
Reference #:  Q7Z406 (UniProtKB)
Alt. Names/Synonyms: DFNA4; DKFZp667A1311; FLJ13881; FLJ43092; FP17425; KIAA2034; MHC16; MYH14; MYH14 variant protein; MYH17; myosin; Myosin heavy chain 14; Myosin heavy chain, non-muscle IIc; myosin, heavy chain 14, non-muscle; myosin, heavy polypeptide 14; Myosin-14; NMHC II-C; NMHC-II-C; Non-muscle myosin heavy chain IIc; nonmuscle myosin heavy chain II-C
Gene Symbols: MYH14
Molecular weight: 227,871 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MYH14

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 G33 PFLFTPRGPsAGGGP
0 2 S35-p LFTPRGPsAGGGPGS
0 1 T44-p GGGPGSGtSPQVEWT
0 1 S60-p RRLVWVPsELHGFEA
0 1 Y137-p YSGLIYTySGLFCVV
0 1 Y154-p PYKQLPIyTEAIVEM
0 1 Y162-p TEAIVEMyRGKKRHE
0 7 Y182 YAVTEGAYRSMLQDR
0 2 Y214-p NTKKVIQyLAHVASs
0 1 S221-p yLAHVASsPKGRKEP
0 4 K252-ub LEAFGNAkTVKNDNS
0 1 K264 DNSSRFGKFIRINFD
0 1 S335-p RFLTNGPsSSPGQER
0 1 T395-p QATMPDNtAAQKLCR
0 1 S412-p GLGVTDFsRALLTPR
0 3 K429-ub VGRDYVQkAQTKEQA
0 1 K433 YVQkAQTKEQADFAL
0 2 K566 WFPKATDKSFVEKVA
0 2 Y674-p FRTVGQLyKESLSRL
0 1 K675 RTVGQLyKESLSRLM
0 1 T684 SLSRLMATLsNTNPs
0 2 S686-p SRLMATLsNTNPsFV
0 1 S691-p TLsNTNPsFVRCIVP
0 1 K706 NHEKRAGKLEPRLVL
0 128 Y778-p LELDPNLyRVGQsKI
0 1 S783-p NLyRVGQsKIFFRAG
0 1 T804-p EERDLKVtDIIVsFQ
0 1 S809-p KVtDIIVsFQAAARG
0 1 S831 QKRQQQQSALRVMQR
0 5 K845-ub RNCAAYLkLRHWQWW
0 1 K857 QWWRLFTKVKPLLQV
0 2 K880-ub ARAQELQkVQELQQQ
0 1 A921 RAEAELCAEAEETRG
0 1 K1038 QAAEEEEKVKSLNKL
0 1 K1048 SLNKLRLKYEATIAD
0 1 K1072 KGRQELEKLKRRLDG
0 1 K1105-ac LRAQLGRkEEELQAA
0 1 T1194-p SKREQEVtELKKTLE
0 1 T1204-p KKTLEEEtRIHEAAV
0 2 A1245 AWEKTRLALEAEVSE
0 1 S1251 LALEAEVSELRAELS
0 1 S1258 SELRAELSSLQTARQ
0 1 S1259 ELRAELSSLQTARQE
0 12 L1276 QRRRRLELQLQEVQG
0 1 K1319 ALNEAESKTIRLSKE
0 1 A1420 RAAREAEALTQRLAE
0 1 T1462 QQRQLVSTLEKKQRK
0 1 K1478 DQLLAEEKAAVLRAV
0 1 K1579 LTAAEDAKLRLEVtV
0 1 T1585-p AKLRLEVtVQALKtQ
0 1 T1591-p VtVQALKtQHERDLQ
0 1 T1630-p DEERKQRtLAVAARK
0 1 K1638 LAVAARKKLEGELEE
0 1 S1652-p ELKAQMAsAGQGkEE
0 1 K1657 MAsAGQGKEEAVKQL
0 1 K1657-m1 MAsAGQGkEEAVKQL
0 1 R1665-m2 EEAVKQLrKMQAQMK
0 1 K1672 rKMQAQMKELWREVE
0 1 S1684 EVEETRTSREEIFSQ
0 1 N1692 REEIFSQNRESEKRL
0 2 K1799-ac AERSFSAkAESGRQQ
0 1 K1859 RERILSGKLVRRAEK
0 1 K1891 QLRDQLEKGNLRVKQ
0 1 K1891 QLRDQLEKGNLRVKQ
1 0 T1953 RRGPLTFTTRTVRQV
0 1 T1954 RGPLTFTTRTVRQVF
1 0 T1956 PLTFTTRTVRQVFRL
0 18 S1969-p RLEEGVAsDEEAEEA
0 1 S1980-p AEEAQPGsGPsPEPE
0 4 S1983-p AQPGsGPsPEPEGsP
0 5 S1989-p PsPEPEGsPPAHPQ_
0 4 H1993 PEGsPPAHPQ_____
  mouse

 
T33-p SFLYAPRtPNVGGPG
N35 LYAPRtPNVGGPGGP
- gap
S56 RRMVWVPSELHGFEA
Y133 YSGLIYTYSGLFCVV
Y150 PYKQLPIYTEAIVEM
Y158 TEAIVEMYRGKKRHE
Y178 YAVTEGAYRSMLQDR
Y210 NTKKVIQYLAHVASS
S217 YLAHVASSPKGRKEP
K256-ub LEAFGNAkTVKNDNS
K268-ac DNSSRFGkFIRINFD
S339 RFLTNGPSSSPGQER
T399 QATMPDNTAAQKLCR
S416 GLGVTDFSRALLTPR
K433-ub VGRDYVQkAQTkEQA
K437-ub YVQkAQTkEQADFAL
K570-ub WFPKATDkSFVEKVA
Y678 FRTVGQLYkESLSRL
K679-ub RTVGQLYkESLSRLM
T688-p SLSRLMAtLsNTNPS
S690-p SRLMAtLsNTNPSFV
S695 tLsNTNPSFVRCIVP
K710 NHEKRAGKLEPRLVL
Y782 LELDPNLYRVGQSKI
S787 NLYRVGQSKIFFRAG
T808 EERDLKVTDIIVSFQ
S813 KVTDIIVSFQAAARG
S835-p QRRQQQQsALRVMQR
K849 RNCAAYLKLRNWQWW
K861 QWWRLFIKVKPLLQV
K884-ub ARAQELQkVQELQQQ
S925-p RAEAELCsEAEETRA
K1042 QAAEEEEKVKSLNKL
K1052 SLNKLRLKYEATISD
K1076 KGRQELEKLKRRLDG
K1109 LLAQLGRKEDELQAA
T1198 SKREQEVTELKKALE
S1208 KKALEEESRAHEVSM
S1249-p VWEKTRLsLEAEVsE
S1255-p LsLEAEVsELKAELs
S1262-p sELKAELssLQTSRQ
S1263-p ELKAELssLQTSRQE
S1280-p QKRRRLEsQLQEVQG
K1323 ALSEAESKAIRLGKE
T1424-p RAAREAEtLTQRLAE
T1466-p QQKQLLStLEKKQRK
K1482 DQLLAEEKAAVLRAV
K1583 LTAAEDAKLRLEVTV
T1589 AKLRLEVTVQALKAQ
A1595 VTVQALKAQHERDLQ
A1634 DEERKQRALAMAARK
K1642 LAMAARKKLELELEE
A1656 ELKAQTSAAGQGKEE
K1661 TSAAGQGKEEAVKQL
K1661 TSAAGQGKEEAVKQL
K1669 EEAVKQLKKMQVQMK
K1676 KKMQVQMKELWREVE
S1688-p EVEETRSsRDEMFTL
S1696-p RDEMFTLsRENEKKL
K1803 AERSFSAKAESGRQQ
K1863 RERILSGKLVRRAEK
K1895 QVRDQLEKSNLRLKQ
K1895-ub QVRDQLEkSNLRLKQ
T1957-p RRGPLTFttRtVRQV
T1958-p RGPLTFttRtVRQVF
T1960-p PLTFttRtVRQVFRL
S1973-p RLEEGVAsDEEEAEG
S1985 AEGAEPGSAPGQEPE
G1988 AEPGSAPGQEPEAPP
P1994 PGQEPEAPPPAtPQ_
T1998-p PEAPPPAtPQ_____
  rat

 
T33 PFLFAPRTPNVGGPG
N35 LFAPRTPNVGGPGGP
- gap
S56 RRMVWVPSELHGFEA
Y133 YSGLIYTYSGLFCVV
Y150 PYKQLPIYTEAIVEM
Y158 TEAIVEMYRGKKRHE
Y178-p YAVTEGAyRSMLQDR
Y210 NTKKVIQYLAHVASS
S217 YLAHVASSPKGRKEP
K256 LEAFGNAKTVKNDNS
K268 DNSSRFGKFIRINFD
S339 RFLTNGPSSSPGQER
T399 QATMPDNTAAQKLCR
S416 GLGVTDFSRALLTPR
K433 VGRDYVQKAQTKEQA
K437 YVQKAQTKEQADFAL
K570 WFPKATDKSFVEKVA
Y678 FRTVGQLYKESLSRL
K679 RTVGQLYKESLSRLM
T688 SLSRLMATLSNTNPS
S690 SRLMATLSNTNPSFV
S695 TLSNTNPSFVRCIVP
K710-ac NHEKRAGkLEPRLVL
Y782 LELDPNLYRVGQSKI
S787 NLYRVGQSKIFFRAG
T808 EERDLKVTDIIVSFQ
S813 KVTDIIVSFQAAARG
S835 QRRQQQQSALRVMQR
K849 RNCAAYLKLRNWQWW
K861-ac QWWRLFIkVKPLLQV
K884 ARAQELQKVQELQQQ
S925 RAEAELCSEAEETRA
K1042-ac QAAEEEEkVKSLNKL
K1052-ac SLNKLRVkYEATIAD
K1076-ac KGRQELEkLKRRLDG
K1109 LLIQLGRKEEELQSA
T1198 SKREQEVTELKKTLE
A1208 KKTLEEEARTHEVAM
S1249 VWEKTRLSLEAEVSE
S1255 LSLEAEVSELKTELS
S1262 SELKTELSSLQTSRQ
S1263 ELKTELSSLQTSRQE
S1280 QKRRRLESQLQEVQG
K1323-ac ALSEAESkAIRLSKE
T1424 RAAREAETLAQRLAE
T1466 QQKQLLSTLEKKQRK
K1482-ac DQLLAEEkAAVLRAV
K1583-ac LTAAEDAkLRLEVTV
T1589 AkLRLEVTVQALKAQ
A1595 VTVQALKAQHERDLQ
A1634 DEERKQRALAMAARK
K1642-ac LAMAARKkLELELEE
A1656 ELKAQTSAAGQGkEE
K1661-ac TSAAGQGkEEAVKQL
K1661 TSAAGQGKEEAVKQL
K1669 EEAVKQLKKMQAQMk
K1676-ac KKMQAQMkELWREVE
S1688 EVEETRSSREEMFTL
S1696 REEMFTLSRESEKRL
K1803-ac AERSFSAkAESGRQQ
K1863-ac RERILSGkLVRRAEK
K1895-ac QLRDQLEkSNLRLKQ
K1895 QLRDQLEKSNLRLKQ
T1957 RRGPLTFTTRTVRQV
T1958 RGPLTFTTRTVRQVF
T1960 PLTFTTRTVRQVFRL
S1973-p RLEEGVAsDEEEAEG
S1985 AEGAEPGSAPTQEPE
T1988 AEPGSAPTQEPEAPP
P1994 PTQEPEAPPPAAPQ_
A1998 PEAPPPAAPQ_____
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