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Protein Page:
NLRC4 (human)

NLRC4 Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Cellular Component: intracellular; cytosol
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; magnesium ion binding; ATP binding
Biological Process: caspase activation; detection of bacterium; positive regulation of apoptosis; defense response to bacterium; innate immune response; interleukin-1 beta secretion; inflammatory response; activation of innate immune response; protein homooligomerization; activation of NF-kappaB transcription factor
Reference #:  Q9NPP4 (UniProtKB)
Alt. Names/Synonyms: CARD, LRR, and NACHT-containing protein; CARD12; caspase recruitment domain family, member 12; Caspase recruitment domain-containing protein 12; CLAN; Clan protein; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; Ice protease-activating factor; ICE-protease activating factor; IPAF; NLR family CARD domain-containing protein 4; NLR family, CARD domain containing 4; NLRC4; NOD-like receptor C4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Gene Symbols: NLRC4
Molecular weight: 116,159 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.




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