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Mad1 (human)

Overview Mad1 Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor; DNA binding protein Cellular Component: mitochondrion; cytoplasm; nucleolus; nucleus Molecular Function: protein dimerization activity; DNA binding; transcription cofactor activity; transcription factor activity; transcription corepressor activity Biological Process: cell proliferation; transcription, DNA-dependent; multicellular organismal development Reference #:  Q05195 (UniProtKB) Alt. Names/Synonyms: MAD; MAD protein (MAX-binding protein); MAD1; Max dimerization protein 1; Max dimerizer 1; MGC104659; MXD1; Protein MAD Gene Symbols: MXD1 Molecular weight: 25,254 Da Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Mad1 1E91 - B=8-20 (human) 1G1E - A=6-21 (human) 1NLW - A/D=57-136 (human) 1PD7 - B=5-28 (human) 1S5Q - A=6-21 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1E91 1G1E 1NLW 1PD7 1S5Q  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S145‑p cell growth, altered: S145‑p transcription, altered: S145‑p molecular association, regulation: S145‑p protein degradation: S145‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K39-a	SMLPYNNkDRDALKR
0	6		S89-p	LVPLGPEssRHTTLS
0	6		S90-p	VPLGPEssRHTTLSL
2	0		S145-p	IERIRMDsIGSTVSS
0	1		S191-p	SDSDERGsMQsLGSD
0	1		S194-p	DERGsMQsLGSDEGy
0	1		Y201-p	sLGSDEGySSTSIKR

	mouse
K38	ASMLPYSKDRDAFKR
S88-p	LVPLGPEssRHTTLS
S89-p	VPLGPEssRHTTLSL
S144	AERTRMDSVGSVVSS
S197	SDSDERGSMQSLGSD
S200	DERGSMQSLGSDEGY
Y207	SLGSDEGYSSATVKR

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