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Protein Page:
Mad1 (human)

Overview
Mad1 Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; DNA binding protein
Cellular Component: nucleus
Molecular Function: protein dimerization activity; DNA binding; transcription cofactor activity; transcription factor activity; transcription corepressor activity
Biological Process: cell proliferation; transcription, DNA-dependent; multicellular organismal development
Reference #:  Q05195 (UniProtKB)
Alt. Names/Synonyms: MAD; MAD protein (MAX-binding protein); MAD1; Max dimerization protein 1; Max dimerizer 1; MGC104659; MXD1; Protein MAD
Gene Symbols: MXD1
Molecular weight: 25,254 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Mad1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S145‑p
cell growth, altered: S145‑p
transcription, induced: S145‑p
molecular association, regulation: S145‑p
protein degradation: S145‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S89-p LVPLGPEssRHTTLS
0 6 S90-p VPLGPEssRHTTLSL
2 0 S145-p IERIRMDsIGSTVSS
  mouse

 
S88-p LVPLGPEssRHTTLS
S89-p VPLGPEssRHTTLSL
S144 AERTRMDSVGSVVSS
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