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Protein Page:
PTPN22 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTPN22 Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T-cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. Interacts with CSK. Interacts with LPXN. Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Down-regulated by phosphorylation. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Cellular Component: internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; nucleus
Molecular Function: protein binding; protein tyrosine phosphatase activity; SH3 domain binding; kinase binding
Biological Process: regulation of B cell receptor signaling pathway; regulation of natural killer cell proliferation; negative regulation of T cell receptor signaling pathway; protein amino acid dephosphorylation; negative regulation of T cell activation; T cell differentiation; regulation of innate immune response
Reference #:  Q9Y2R2 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; LYP1; LYP2; PEP; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; PTN22; PTPN22; PTPN8; Tyrosine-protein phosphatase non-receptor type 22
Gene Symbols: PTPN22
Molecular weight: 91,705 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTPN22

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, inhibited: S35‑p
protein conformation: S35‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S35-p FLKLKRQsTKYKADK
0 1 Y84-p TSDEDSSyINANFIK
0 1 T173-p KSDYIIRtLKVKFNS
0 1 K364-ac RTSEISAkEELVLHP
0 1 K373-ac ELVLHPAkSSTSFDF
0 3 F402 MKWQTKAFPIVGEPL
0 5 S414-p EPLQKHQsLDLGSLL
0 1 T447-p SKVPITRtKsTPFEL
0 5 S449-p VPITRtKsTPFELIQ
0 1 T450 PITRtKsTPFELIQQ
0 1 S493 AQKVMHVSSAELNys
0 1 S494 QKVMHVSSAELNysL
0 59 Y499-p VSSAELNysLPYDSK
0 3 S500-p SSAELNysLPYDSKH
0 1 Y526-p DSSALGVysyIPLVE
0 1 S527-p SSALGVysyIPLVEN
0 1 Y528-p SALGVysyIPLVENP
0 1 Y536-p IPLVENPyFSSWPPS
0 1 S635 VEEAGEFSPNVPKSL
0 1 S653-p VKVKIGTsLEWGGTS
0 1 S684 VKLRSPKSELHQDRS
0 5 S692 ELHQDRSSPPPPLPE
0 1 T741-p SSKQTLKtSGKSFtR
0 1 T747-p KtSGKSFtRSKsLKI
0 1 S751-p KSFtRSKsLKILRNM
  mouse

 
S35 FLKLKRQSTKYKADK
Y84 TSDEDSSYINASFIK
T173 KSDYKIRTLKAKFNN
E367 RTSTMNAEEELVLHS
K376 ELVLHSAKSSPSFNC
S405-p RNGQARAsPVVGEPL
S417 EPLQKYQSLDFGSML
T450-p SKGPVKRtKstPFEL
S452-p GPVKRtKstPFELIQ
T453-p PVKRtKstPFELIQQ
S497-p VQRVAHVssEELNYS
S498-p QRVAHVssEELNYSL
Y503 VssEELNYSLPGACD
S504 ssEELNYSLPGACDA
H525 SPGALRVHLYTSLAE
L526 PGALRVHLYTSLAED
Y527 GALRVHLYTSLAEDP
Y535 TSLAEDPYFSSSPPN
S634-p VEEAGEPsPRVTESL
S650 LVVTFGASPECSGTS
S680-p VKLRSPKsDRHQDGs
S687-p sDRHQDGsPPPPLPE
T736 SSKQTLRTPGKSFTR
T742 RTPGKSFTRSKSLKI
S746 KSFTRSKSLKIFRNM
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