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Protein Page:
eIF2B-delta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF2B-delta Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Translation; Translation initiation
Cellular Component: eukaryotic translation initiation factor 2B complex; cytoplasm; cytosol
Molecular Function: protein binding; translation initiation factor binding; translation initiation factor activity; guanyl-nucleotide exchange factor activity; S-methyl-5-thioribose-1-phosphate isomerase activity
Biological Process: myelination; response to peptide hormone stimulus; negative regulation of translational initiation; translation; cellular response to stimulus; regulation of translation; cellular protein metabolic process; ovarian follicle development; methionine salvage; response to heat; response to glucose stimulus; translational initiation; negative regulation of translation initiation in response to stress; gene expression; oligodendrocyte development; regulation of translational initiation; positive regulation of GTPase activity
Reference #:  Q9UI10 (UniProtKB)
Alt. Names/Synonyms: DKFZp586J0119; EI2BD; EIF-2B; eIF-2B GDP-GTP exchange factor subunit delta; EIF2B; EIF2B4; EIF2BD; EIF2Bdelta; eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; translation initiation factor eIF-2b delta subunit; Translation initiation factor eIF-2B subunit delta
Gene Symbols: EIF2B4
Molecular weight: 57,557 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Select Structure to View Below

eIF2B-delta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 S12-p AVAVREDsGSGMKAE
0 1 S65 PETGSAVSAAQCQVG
0 1 T74 AQCQVGPTRELPESG
0 1 S80 PTRELPESGIQLGtP
0 24 T86-p ESGIQLGtPREKVPA
0 5 S130-p GGPPPKAsPSTAGEt
0 2 T137-p sPSTAGEtPSGVKRL
0 20 Y147-p GVKRLPEyPQVDDLL
0 2 K176-ub TRKDYGSkVSLFSHL
0 1 Y186-p LFSHLPQysRQNsLT
0 1 S187-p FSHLPQysRQNsLTQ
0 4 S191-p PQysRQNsLTQFMSI
0 1 T193 ysRQNsLTQFMSIPS
0 1 Y214-p MVRLGLQySQGLVSG
0 2 K282-ub NAIKFLNkEITSVGS
0 1 S328-p RFAYQKIsNGDVILV
0 1 S340-p ILVYGCSsLVSRILQ
0 1 S384-p VHAGVPAsyLLIPAA
0 1 Y385-p HAGVPAsyLLIPAAS
0 1 S399-p SYVLPEVsKVLLGAH
0 1 K466-ac DPDDLQCkRGEHVAL
0 2 K466-ub DPDDLQCkRGEHVAL
  eIF2B-delta iso2  
S19 RAPKPSRSLSGSLCA
S23 PSRSLSGSLCALFSD
S33 ALFSDADSGSGMKAE
S86-p PETGSAVsAAQCQGP
T94-p AAQCQGPtRELPEsG
S100-p PtRELPEsGIQLGtP
T106-p EsGIQLGtPREKVPA
S150 GGPPPKASPSTAGET
T157 SPSTAGETPSGVKRL
Y167 GVKRLPEYPQVDDLL
K196 TRKDYGSKVSLFSHL
Y206 LFSHLPQYSRQNSLT
S207 FSHLPQYSRQNSLTQ
S211 PQYSRQNSLTQFMSI
T213 YSRQNSLTQFMSIPS
Y234 MVRLGLQYSQGLVSG
K302 NAIKFLNKEITSVGS
S348 RFAYQKISNGDVILV
S360 ILVYGCSSLVSRILQ
S404 VHAGVPASYLLIPAA
Y405 HAGVPASYLLIPAAS
S419 SYVLPEVSKVLLGAH
K486 DPDDLQCKRGEHVAL
K486 DPDDLQCKRGEHVAL
  mouse

► Hide Isoforms
 
- gap
- gap
S12 AVAVREESRSEMKTE
S65 QEIGSAVSAAQRQDP
I73 AAQRQDPIRELPGPG
P79 PIRELPGPGSQLGGT
T86 PGSQLGGTAGEKLPA
C130 GGVPPQACPSTAGET
T137 CPSTAGETTSGVKRV
H147 GVKRVPEHTPADDPT
K177-ub TRKDYGSkVSLFSHL
Y187 LFSHLPQYSRQSsLt
S188 FSHLPQYSRQSsLtQ
S192-p PQYSRQSsLtQYMSI
T194-p YSRQSsLtQYMSIPS
Y215 MVRLGLQYSQGLISG
K283 NAIKFLTKEVTGMSS
S329 RFASTKISDGDVILV
S341 ILVYGCSSLVSRILQ
S385 VRAGVPTSYLLIPAA
Y386 RAGVPTSYLLIPAAS
S400 SYVLPEVSKVLLGAH
K467 DPDDLQCKRGDQVAL
K467 DPDDLQCKRGDQVAL
  eIF2B-delta iso2  
S19-p SLPKSSRsLSGsLCA
S23-p SSRsLSGsLCALFSD
S33 ALFSDAESRSEMKTE
S86 QEIGSAVSAAQRQDP
I94 AAQRQDPIRELPGPG
P100 PIRELPGPGSQLGGT
T107 PGSQLGGTAGEKLPA
C151 GGVPPQACPSTAGET
T158 CPSTAGETTSGVKRV
H168 GVKRVPEHTPADDPT
K198 TRKDYGSKVSLFSHL
Y208 LFSHLPQYSRQSSLT
S209 FSHLPQYSRQSSLTQ
S213 PQYSRQSSLTQYMSI
T215 YSRQSSLTQYMSIPS
Y236 MVRLGLQYSQGLISG
K304 NAIKFLTKEVTGMSS
S350 RFASTKISDGDVILV
S362 ILVYGCSSLVSRILQ
S406 VRAGVPTSYLLIPAA
Y407 RAGVPTSYLLIPAAS
S421 SYVLPEVSKVLLGAH
K488 DPDDLQCKRGDQVAL
K488 DPDDLQCKRGDQVAL
  rat

 
- gap
- gap
S12 AVAVREESRSEMKTE
S65 QEIGSAVSAAQRQDP
V73 AAQRQDPVRELQGTG
T79 PVRELQGTGSQLGGT
T86 TGSQLGGTTGEKLPA
C130 GGPSPQACPSTAGEA
A137 CPSTAGEATSGVKRV
H147 GVKRVPEHTQADDPT
K177 TRKDYGSKVSLFSHL
Y187 LFSHLPQYSRQSSLT
S188 FSHLPQYSRQSSLTQ
S192 PQYSRQSSLTQYMSI
T194 YSRQSSLTQYMSIPS
Y215 MVRLGLQYSQGLVSG
K283 NAIKFFNKEVTGMSS
S329 RFASKKISDGDVILV
S341 ILVYGCSSLVSRILQ
S385 VRAGVPTSYLLIPAA
Y386 RAGVPTSYLLIPAAS
S400 SYVLPEVSKVLLGAH
K467 DPDDLQCKRGDQVTL
K467 DPDDLQCKRGDQVTL
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