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Protein Page:
GABRA1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GABRA1 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4). A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood. Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transporter, ion channel; Transporter; Membrane protein, multi-pass; Channel, ligand-gated
Cellular Component: postsynaptic membrane; membrane; integral to plasma membrane; integral to membrane; plasma membrane; synapse; cell junction
Molecular Function: protein binding; chloride channel activity; GABA-A receptor activity; GABA receptor activity; ion channel activity; drug binding; extracellular ligand-gated ion channel activity
Biological Process: transport; synaptic transmission, GABAergic; ion transport; chloride transport; gamma-aminobutyric acid signaling pathway
Reference #:  P62812 (UniProtKB)
Alt. Names/Synonyms: GABA(A) receptor subunit alpha-1; GABAA alpha 1; Gabra-1; Gabra1; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1; Gamma-aminobutyric acid receptor subunit alpha-1; GBRA1; OTTMUSP00000005606
Gene Symbols: Gabra1
Molecular weight: 51,754 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Select Structure to View Below

GABRA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S22 TLILSTLSGRSYGQP
0 1 Y86 VSDHDMEYTIDVFFR
0 1 T87 SDHDMEYTIDVFFRQ
0 1 Y155 TEDGTLLYTMRLTVR
0 1 Y341-p NYFTKRGyAWDGKsV
0 1 S347-p GyAWDGKsVVPEKPK
0 1 K363-ub VKDPLIKkNNTyAPT
0 1 T366 PLIKkNNTyAPTATS
0 43 Y367-p LIKkNNTyAPTATSy
0 9 Y374-p yAPTATSytPNLARG
2 4 T375-p APTATSytPNLARGD
0 1 K390-ub PGLATIAkSATIEPK
  human

 
T22-p ILLLSTLtGRSYGQP
Y87-p VSDHDMEytIDVFFR
T88-p SDHDMEytIDVFFRQ
Y156-p TEDGTLLyTMRLTVR
Y342 NYFTKRGYAWDGKSV
S348 GYAWDGKSVVPEKPK
K364 VKDPLIKKNNTyAPT
T367 PLIKKNNTyAPTATS
Y368-p LIKKNNTyAPTATSy
Y375-p yAPTATSyTPNLARG
T376 APTATSyTPNLARGD
K391 PGLATIAKSATIEPK
  rat

 
S22 TLILSTLSGRSYGQP
Y86 VSDHDMEYTIDVFFR
T87 SDHDMEYTIDVFFRQ
Y155 TEDGTLLYTMRLTVR
Y341 NYFTKRGYAWDGKSV
S347 GYAWDGKSVVPEKPK
K363 VKDPLIKKNNtyAPT
T366-p PLIKKNNtyAPTATS
Y367-p LIKKNNtyAPTATSy
Y374-p yAPTATSytPNLARG
T375-p APTATSytPNLARGD
K390 PGLATIAKSATIEPK
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