Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Hematopoietic specific. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric, Rho; Motility/polarity/chemotaxis; G protein, monomeric
Molecular Function: GTPase activity; GTP binding; protein kinase regulator activity
Biological Process: regulation of mast cell degranulation; platelet activation; axon guidance; metabolic process; regulation of T cell proliferation; actin filament organization; cell projection biogenesis; signal transduction; G-protein coupled receptor protein signaling pathway; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of cell proliferation; regulation of protein kinase activity; blood coagulation; bone resorption; regulation of hydrogen peroxide metabolic process
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.