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Protein Page:
Rac2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Rac2 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Hematopoietic specific. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Cellular Component: plasma membrane; nuclear envelope; cytosol
Molecular Function: GTPase activity; GTP binding
Biological Process: platelet activation; axon guidance; regulation of small GTPase mediated signal transduction; GTP catabolic process; small GTPase mediated signal transduction; positive regulation of cell proliferation; cell projection biogenesis; actin cytoskeleton organization and biogenesis; signal transduction; blood coagulation; regulation of hydrogen peroxide metabolic process; bone resorption
Reference #:  P15153 (UniProtKB)
Alt. Names/Synonyms: EN-7; GX; HSPC022; p21-Rac2; RAC2; Ras-related C3 botulinum toxin substrate 2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); rho family, small GTP binding protein Rac2; Small G protein
Gene Symbols: RAC2
Molecular weight: 21,429 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Rac2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y32-p TNAFPGEyIPTVFDN
0 32 Y64-p DTAGQEDyDRLRPLS
0 3 K96-ub SYENVRAkWFPEVRH
0 10 K116-ub PIILVGTkLDLRDDk
0 4 K123-ub kLDLRDDkDTIEKLK
0 8 K133-ub IEKLKEKkLAPITYP
0 2 K147-ac PQGLALAkEIDSVKY
0 13 K147-ub PQGLALAkEIDSVKY
0 1 K153 AkEIDSVKYLECSAL
0 4 T161-p YLECSALtQRGLktV
0 5 K166-ub ALtQRGLktVFDEAI
0 14 T167-p LtQRGLktVFDEAIR
  mouse

 
Y32 TNAFPGEYIPTVFDN
Y64 DTAGQEDYDRLRPLS
K96 SYENVRAKWFPEVRH
K116-ub PIILVGTkLDLRDDk
K123-ub kLDLRDDkDTIEKLK
K133 IEKLKEKKLAPITYP
K147 PQGLALAKDIDSVkY
K147-ub PQGLALAkDIDSVkY
K153-ub AkDIDSVkYLECSAL
T161-p YLECSALtQRGLktV
K166-ub ALtQRGLktVFDEAI
T167-p LtQRGLktVFDEAIR
  rat

 
Y32 TNAFPGEYIPTVFDN
Y64 DTAGQEDYDRLRPLS
K96 SYENVRAKWFPEVRH
K116 PIILVGTKLDLRDDK
K123 KLDLRDDKDTIEKLK
K133 IEKLKEKKLAPITYP
K147 PQGLALAKDIDSVKY
K147 PQGLALAKDIDSVKY
K153 AKDIDSVKYLECSAL
T161 YLECSALTQRGLKTV
K166 ALTQRGLKTVFDEAI
T167 LTQRGLKTVFDEAIR
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