Home

Rac2 (human)

Overview Rac2 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Hematopoietic specific. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB. Protein type: G protein, monomeric (Rho); G protein; Motility/polarity/chemotaxis Cellular Component: plasma membrane; nuclear envelope; cytosol Molecular Function: GTPase activity; GTP binding Biological Process: platelet activation; axon guidance; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of cell proliferation; cell projection biogenesis; blood coagulation; actin cytoskeleton organization and biogenesis; signal transduction; regulation of hydrogen peroxide metabolic process; bone resorption Reference #:  P15153 (UniProtKB) Alt. Names/Synonyms: EN-7; GX; HSPC022; p21-Rac2; RAC2; Ras-related C3 botulinum toxin substrate 2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); rho family, small GTP binding protein Rac2; Small G protein Gene Symbols: RAC2 Molecular weight: 21,429 Da Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  Regulation of Actin Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Rac2 1DS6 - A=1-192 (human) 2W2T - A=2-179 (human) 2W2V - A/D/C/B=1-177 (human) 2W2X - A/B=2-179 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1DS6 2W2T 2W2V 2W2X  |  Phospho3D  |  DISEASE 602049 608203  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y32-p	TNAFPGEyIPTVFDN
0	30		Y64-p	DTAGQEDyDRLRPLS
0	3		K96-u	SYENVRAkWFPEVRH
0	1		T108-p	VRHHCPStPIILVGT
0	10		K116-u	PIILVGTkLDLRDDk
0	4		K123-u	kLDLRDDkDTIEKLK
0	8		K133-u	IEKLKEKkLAPITYP
0	2		K147-a	PQGLALAkEIDSVKY
0	13		K147-u	PQGLALAkEIDSVKY
0	1		K153	AkEIDSVKYLECSAL
0	6		T161-p	YLECSALtQRGLktV
0	5		K166-u	ALtQRGLktVFDEAI
0	11		T167-p	LtQRGLktVFDEAIR

	mouse
Y32	TNAFPGEYIPTVFDN
Y64	DTAGQEDYDRLRPLS
K96	SYENVRAKWFPEVRH
T108	VRHHCPSTPIILVGT
K116-u	PIILVGTkLDLRDDk
K123-u	kLDLRDDkDTIEKLK
K133	IEKLKEKKLAPITYP
K147	PQGLALAKDIDSVkY
K147-u	PQGLALAkDIDSVkY
K153-u	AkDIDSVkYLECSAL
T161-p	YLECSALtQRGLktV
K166-u	ALtQRGLktVFDEAI
T167-p	LtQRGLktVFDEAIR

	rat
Y32	TNAFPGEYIPTVFDN
Y64	DTAGQEDYDRLRPLS
K96	SYENVRAKWFPEVRH
T108	VRHHCPSTPIILVGT
K116	PIILVGTKLDLRDDK
K123	KLDLRDDKDTIEKLK
K133	IEKLKEKKLAPITYP
K147	PQGLALAKDIDSVKY
K147	PQGLALAKDIDSVKY
K153	AKDIDSVKYLECSAL
T161-p	YLECSALtQRGLKTV
K166	ALtQRGLKTVFDEAI
T167	LtQRGLKTVFDEAIR

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.