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Protein Page:
Ets-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ets-1 a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Motility/polarity/chemotaxis; DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex; intercellular bridge; cytoplasm; nucleolus; nucleus
Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; hypothalamus development; positive regulation of erythrocyte differentiation; positive regulation of transcription, DNA-dependent; cell motility involved in cell locomotion; PML body organization and biogenesis; positive regulation of cell motility; female pregnancy; angiogenesis involved in wound healing; regulation of angiogenesis; response to estradiol stimulus; negative regulation of cell cycle; response to antibiotic; regulation of apoptosis; negative regulation of cell proliferation; estrous cycle phase; positive regulation of angiogenesis; response to mechanical stimulus; pituitary gland development; positive regulation of cell proliferation; response to hypoxia; immune response; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P14921 (UniProtKB)
Alt. Names/Synonyms: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; ets protein; ETS-1; ETS1; EWSR2; FLJ10768; p54; Protein C-ets-1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
Gene Symbols: ETS1
Molecular weight: 50,408 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ets-1

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: T38‑p
transcription, altered: T38‑p
transcription, induced: T38‑p
transcription, inhibited: S251‑p, S257‑p, S282‑p, S285‑p
activity, induced: T38‑p
activity, inhibited: S251‑p, S257‑p, S282‑p, S285‑p
molecular association, regulation: S251‑p, S257‑p, S282‑p, S285‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K2-ac ______MkAAVDLkP
0 1 K8-ac MkAAVDLkPTLTIIk
0 1 K15-ac kPTLTIIkTEKVDLE
3 0 K15 kPTLTIIKTEKVDLE
0 6 S26-p VDLELFPsPDMECAD
0 1 - gap
0 1 - gap
0 1 - gap
9 5 T38-p CADVPLLtPSSKEMM
1 0 S41 VPLLtPSSKEMMsQA
0 2 S46-p PSSKEMMsQALKATF
0 3 K58-ub ATFSGFTkEQQRLGI
0 4 K138-ub ILQKEDVkPyQVNGV
0 25 Y140-p QKEDVkPyQVNGVNP
0 25 Y158-p ESRYTSDyFISYGIE
0 1 K200-sm SEELLSLkYENDyPs
0 11 Y205-p SLkYENDyPsVILRD
0 4 S207-p kYENDyPsVILRDPL
0 23 Y223-p TDTLQNDyFAIKQEV
2 0 K227 QNDyFAIKQEVVtPD
0 4 T232-p AIKQEVVtPDNMCMG
2 5 S251-p GKLGGQDsFEsIEsy
0 1 S254-p GGQDsFEsIEsyDsC
2 1 S257-p DsFEsIEsyDsCDRL
0 3 Y258-p sFEsIEsyDsCDRLt
0 1 S260-p EsIEsyDsCDRLtQs
0 1 T265-p yDsCDRLtQsWSsQs
0 2 S267-p sCDRLtQsWSsQssF
0 3 S270-p RLtQsWSsQssFNsL
0 4 S272-p tQsWSsQssFNsLQR
0 10 S273-p QsWSsQssFNsLQRV
1 0 S276-p SsQssFNsLQRVPsy
5 91 S282-p NsLQRVPsyDsFDsE
1 20 Y283-p sLQRVPsyDsFDsED
4 59 S285-p QRVPsyDsFDsEDyP
0 7 S288-p PsyDsFDsEDyPAAL
0 21 Y291-p DsFDsEDyPAALPNH
0 1 K305-ac HKPKGTFkDYVRDRA
0 1 K377 EVARRWGKRKNKPKM
0 1 K379 ARRWGKRKNKPKMNY
0 1 K381 RWGKRKNKPKMNYEk
0 1 K388-ub KPKMNYEkLSRGLRy
0 1 Y395-p kLSRGLRyYYDKNII
  Ets-1 iso3  
- gap
- gap
- gap
- gap
- gap
S2-p ______MsYFVDsAG
S7-p _MsYFVDsAGSSPVP
Y15-p AGSSPVPySAPRPAV
T82 CADVPLLTPSSKEMM
S85 VPLLTPSSKEMMSQA
S90 PSSKEMMSQALKATF
K102 ATFSGFTKEQQRLGI
K182 ILQKEDVKPYQVNGV
Y184 QKEDVKPYQVNGVNP
Y202 ESRYTSDYFISYGIE
K244 SEELLSLKYENDYPS
Y249 SLKYENDYPSVILRD
S251 KYENDYPSVILRDPL
Y267 TDTLQNDYFAIKQEV
K271 QNDYFAIKQEVVTPD
T276 AIKQEVVTPDNMCMG
S295 GKLGGQDSFESIESY
S298 GGQDSFESIESYDSC
S301 DSFESIESYDSCDRL
Y302 SFESIESYDSCDRLT
S304 ESIESYDSCDRLTQS
T309 YDSCDRLTQSWSSQS
S311 SCDRLTQSWSSQSSF
S314 RLTQSWSSQSSFNSL
S316 TQSWSSQSSFNSLQR
S317 QSWSSQSSFNSLQRV
S320 SSQSSFNSLQRVPSY
S326 NSLQRVPSYDSFDSE
Y327 SLQRVPSYDSFDSED
S329 QRVPSYDSFDSEDYP
S332 PSYDSFDSEDYPAAL
Y335 DSFDSEDYPAALPNH
K349 HKPKGTFKDYVRDRA
K421 EVARRWGKRKNKPKM
K423 ARRWGKRKNKPKMNY
K425 RWGKRKNKPKMNYEK
K432 KPKMNYEKLSRGLRY
Y439 KLSRGLRYYYDKNII
  mouse

 
K2 ______MKAAVDLKP
K8 MKAAVDLKPTLTIIk
K15 KPTLTIIKTEKVDLE
K15-sm KPTLTIIkTEKVDLE
S26 VDLELFPSPDMECAD
- gap
- gap
- gap
T38-p CADVPLLtPSsKEMM
S41-p VPLLtPSsKEMMSQA
S46 PSsKEMMSQALKATF
K58-ub ATFSGFTkEQQRLGI
K138 ILQKEDVKPYQVNGA
Y140 QKEDVKPYQVNGANP
Y158 ESCYTSDYFISYGIE
K200 SEELLSLKYENDYPS
Y205 SLKYENDYPSVILQD
S207 KYENDYPSVILQDPL
Y223 TDTLQTDYFAIkQEV
K227-sm QTDYFAIkQEVLTPD
T232 AIkQEVLTPDNMCLG
S251-p GKLGGQDsFEsVESY
S254-p GGQDsFEsVESYDSC
S257 DsFEsVESYDSCDRL
Y258 sFEsVESYDSCDRLT
S260 EsVESYDSCDRLTQS
T265 YDSCDRLTQSWSSQS
S267 SCDRLTQSWSSQSSF
S270 RLTQSWSSQSSFNSL
S272 TQSWSSQSSFNSLQR
S273 QSWSSQSSFNSLQRV
S276 SSQSSFNSLQRVPsy
S282-p NSLQRVPsyDsFDYE
Y283-p SLQRVPsyDsFDYED
S285-p QRVPsyDsFDYEDYP
Y288 PsyDsFDYEDYPAAL
Y291 DsFDYEDYPAALPNH
K305 HKPKGTFKDYVRDRA
K377-ub EVARRWGkRkNkPKM
K379-ub ARRWGkRkNkPKMNY
K381-ub RWGkRkNkPKMNYEK
K388 kPKMNYEKLSRGLRY
Y395 KLSRGLRYYYDKNII
  rat

 
K2-ac ______MkAAVDLkP
K8-ac MkAAVDLkPTLTIIK
K15 kPTLTIIKTEKVDLE
K15 kPTLTIIKTEKVDLE
S26 VDLELFPSPDMECAD
- gap
- gap
- gap
T38 CADVPLLTPSSKEMM
S41 VPLLTPSSKEMMSQA
S46 PSSKEMMSQALKATF
K58 ATFSGFTKEQQRLGI
K138 ILQKEDVKPYQVNGV
Y140 QKEDVKPYQVNGVNP
Y158 ESRYTSDYFISYGIE
K200 SEELLSLKYENDYPS
Y205 SLKYENDYPSVILRD
S207 KYENDYPSVILRDPL
Y223 TDTLQTDYFAIKQEV
K227 QTDYFAIKQEVLTPD
T232 AIKQEVLTPDNMCMG
S251-p GKLGGQDsFEsIESY
S254-p GGQDsFEsIESYDSC
S257 DsFEsIESYDSCDRL
Y258 sFEsIESYDSCDRLT
S260 EsIESYDSCDRLTQS
T265 YDSCDRLTQSWSSQS
S267 SCDRLTQSWSSQSSF
S270 RLTQSWSSQSSFNSL
S272 TQSWSSQSSFNSLQR
S273 QSWSSQSSFNSLQRV
S276 SSQSSFNSLQRVPsy
S282-p NSLQRVPsyDsFDsE
Y283-p SLQRVPsyDsFDsED
S285-p QRVPsyDsFDsEDYP
S288-p PsyDsFDsEDYPAAL
Y291 DsFDsEDYPAALPNH
K305 HKPKGTFKDYVRDRA
K377 EVARRWGKRKNKPKM
K379 ARRWGKRKNKPKMNY
K381 RWGKRKNKPKMNYEK
K388 KPKMNYEKLSRGLRY
Y395 KLSRGLRYYYDKNII
  chicken

 
K2 ______MKAAVDLKP
K8 MKAAVDLKPTLTIIK
K15 KPTLTIIKTEKVDID
K15 KPTLTIIKTEKVDID
S26 VDIDLFPSPDMECAD
- gap
- gap
- gap
T38 CADVPLLTPSSKEMM
S41 VPLLTPSSKEMMSQA
S46 PSSKEMMSQALKATF
K58 ATFSGFAKEQQRLGI
K138 ILQKEEAKPYPANGV
Y140 QKEEAKPYPANGVNA
Y158 ESRYTSDYFISYGIE
K200 SEELLSLKYENDYPS
Y205 SLKYENDYPSVILRD
S207 KYENDYPSVILRDPV
Y223 TDSLQTDYFTIKQEV
K227 QTDYFTIKQEVVTPD
T232 TIKQEVVTPDNMCMG
S251-p GKLGGQDsFESIEsY
S254 GGQDsFESIEsYDSC
S257-p DsFESIEsYDSCDRL
Y258 sFESIEsYDSCDRLT
S260 ESIEsYDSCDRLTQS
T265 YDSCDRLTQSWSSQS
S267 SCDRLTQSWSSQSSF
S270 RLTQSWSSQSSFQSL
S272 TQSWSSQSSFQSLQR
S273 QSWSSQSSFQSLQRV
S276 SSQSSFQSLQRVPsY
S282-p QSLQRVPsYDsFDSE
Y283 SLQRVPsYDsFDSED
S285-p QRVPsYDsFDSEDYP
S288 PsYDsFDSEDYPAAL
Y291 DsFDSEDYPAALPNH
K305 HKPKGTFKDYVRDRA
K377 EVARRWGKRKNKPKM
K379 ARRWGKRKNKPKMNY
K381 RWGKRKNKPKMNYEK
K388 KPKMNYEKLSRGLRY
Y395 KLSRGLRYYYDKNII
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