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Protein Page:
CPT1B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CPT1B a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009]
Protein type: Membrane protein, multi-pass; Lipid Metabolism - fatty acid; Transferase; Membrane protein, integral; EC 2.3.1.21
Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane
Molecular Function: carnitine O-palmitoyltransferase activity
Biological Process: fatty acid beta-oxidation; cellular lipid metabolic process; carnitine shuttle
Reference #:  Q92523 (UniProtKB)
Alt. Names/Synonyms: Carnitine O-palmitoyltransferase 1, muscle isoform; carnitine O-palmitoyltransferase I, mitochondrial muscle isoform; Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1B; carnitine palmitoyltransferase 1B (muscle); Carnitine palmitoyltransferase I-like protein; CPT I; CPT1-M; CPT1B; CPT1M; CPTI; CPTI-M; FLJ55729; FLJ58750; KIAA1670; M-CPT1; MCCPT1; MCPT1
Gene Symbols: CPT1B
Molecular weight: 87,801 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Select Structure to View Below

CPT1B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y32-p REALKHVyLsGINsW
0 1 S34-p ALKHVyLsGINsWkk
0 1 S38-p VyLsGINsWkkRLIR
0 3 K40-ac LsGINsWkkRLIRIK
0 3 K41-ac sGINsWkkRLIRIKN
0 1 K47 kkRLIRIKNGILRGV
0 1 T171-p PMLYSFQtSLPKLPV
0 1 L206 EEYYRMELLAKEFQD
0 1 K209 YRMELLAKEFQDKTA
0 1 K321 NTTRIPGKDTDVLQH
0 1 S330-p TDVLQHLsDSRHVAV
0 1 K345-ac YHKGRFFkLWLyEGA
0 8 Y349-p RFFkLWLyEGARLLK
0 1 K380 PPQPGEEKLAALTAG
0 3 K404 QAFFSSGKNKAALEA
0 1 K404 QAFFSSGKNKAALEA
0 47 Y449-p ALLHGNCyNRWFDKS
0 1 S533-p CQAVIESsyQVAKAL
0 39 Y534-p QAVIESsyQVAKALA
0 7 Y547 LADDVELYCFQFLPF
0 1 E621 AFVQAMMEGSHTKAD
0 1 K626 MMEGSHTKADLRDLF
0 1 S743 ISSKFSSSETNAQRF
0 1 Q766 LDIADLFQVPKAYS_
  CPT1B iso4  
Y32 REALKHVYLSGINSW
S34 ALKHVYLSGINSWKK
S38 VYLSGINSWKKRLIR
K40 LSGINSWKKRLIRIK
K41 SGINSWKKRLIRIKN
K47 KKRLIRIKNGILRGV
T171 PMLYSFQTSLPKLPV
L206 EEYYRMELLAKEFQD
K209 YRMELLAKEFQDKTA
K321 NTTRIPGKDTDVLQH
S330 TDVLQHLSDSRHVAV
K345 YHKGRFFKLWLYEGA
Y349 RFFKLWLYEGARLLS
- gap
- gap
- gap
Y368 ALLHGNCYNRWFDKS
S452 CQAVIESSYQVAKAL
Y453 QAVIESSYQVAKALA
Y466 LADDVELYCFQFLPF
E540 AFVQAMMEGSHTKAD
K545 MMEGSHTKADLRDLF
S662 ISSKFSSSETNAQRF
Q685 LDIADLFQVPKAYS_
  mouse

 
Y32 REALRHIYLSGINSW
S34 ALRHIYLSGINSWKk
S38 IYLSGINSWKkRLIR
K40 LSGINSWKkRLIRIk
K41-ac SGINSWKkRLIRIkN
K47-ub KkRLIRIkNGILRGV
T171 PMLYSFQTSLPKLPV
T206-p EAYYRMEtLAkEFQD
K209-ub YRMEtLAkEFQDKTA
K321-ub NTTRIPGkETDLLQH
S330 TDLLQHLSESRHVAV
K345 YHKGRFFKVWLyEGS
Y349-p RFFKVWLyEGSRLLK
K380-ub PPQPGEEkLAALTAG
K404-ac QTFFSSGkNKMSLDA
K404-ub QTFFSSGkNKMSLDA
Y449-p ALLHGNCyNRWFDKS
S533 CREAIENSyQVAKAL
Y534-p REAIENSyQVAKALA
Y547 LADDVELYCFQFLPF
K621-ub AFVQAMMkGSHKkQD
K626-ub MMkGSHKkQDLQDLF
S743 ISSKYSSSETNAQRF
K766-ub LDIAELFkISKTDS_
  rat

 
Y32 REALRHIYLSGINSW
S34 ALRHIYLSGINSWKK
S38 IYLSGINSWKKRLIR
K40 LSGINSWKKRLIRIK
K41 SGINSWKKRLIRIKN
K47 KKRLIRIKNGILRGV
T171 PMLYSFQTSLPKLPV
S206 EAYFRMESLAKEFQD
K209 FRMESLAKEFQDKIA
K321 NTTRIPGKETDLLQH
S330 TDLLQHLSESRHVAV
K345 YHKGRFFKVWLYEGS
Y349 RFFKVWLYEGSCLLK
K380 PPQPGEEKLAALTAG
K404 QKFFSSGKNKMSLDT
K404 QKFFSSGKNKMSLDT
Y449 SLLHGNCYNRWFDKS
S533 CQTAIENSYQVAKAL
Y534 QTAIENSYQVAKALA
Y547-p LADDVELyCFQFLPF
T621 AFVRAMMTGSHKKQD
K626 MMTGSHKKQDLQDLF
S743-p VSSKLSSsETNALRF
K766 LDIADLFKISKTDS_
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