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CPT1B (human)

Overview CPT1B a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009] Protein type: Transferase; Lipid Metabolism - fatty acid; Membrane protein, integral; EC 2.3.1.21 Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane Molecular Function: carnitine O-palmitoyltransferase activity Biological Process: fatty acid beta-oxidation; regulation of fatty acid oxidation; carnitine shuttle; cellular lipid metabolic process Reference #:  Q92523 (UniProtKB) Alt. Names/Synonyms: Carnitine O-palmitoyltransferase 1, muscle isoform; carnitine O-palmitoyltransferase I, mitochondrial muscle isoform; Carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1B; carnitine palmitoyltransferase 1B (muscle); Carnitine palmitoyltransferase I-like protein; CPT I; CPT1-M; CPT1B; CPT1M; CPTI; CPTI-M; FLJ55729; FLJ58750; KIAA1670; M-CPT1; MCCPT1; MCPT1 Gene Symbols: CPT1B Molecular weight: 87,801 Da Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling

Select Structure to View Below CPT1B

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		Y32-p	REALKHVyLsGINsW
0	1		S34-p	ALKHVyLsGINsWkk
0	1		S38-p	VyLsGINsWkkRLIR
0	3		K40-a	LsGINsWkkRLIRIK
0	3		K41-a	sGINsWkkRLIRIKN
0	1		K47	kkRLIRIKNGILRGV
0	1		T171-p	PMLYSFQtSLPKLPV
0	1		L206	EEYYRMELLAKEFQD
0	1		K209	YRMELLAKEFQDKTA
0	1		K321	NTTRIPGKDTDVLQH
0	1		S330-p	TDVLQHLsDSRHVAV
0	1		K345-a	YHKGRFFkLWLyEGA
0	7		Y349-p	RFFkLWLyEGARLLK
0	1		K380	PPQPGEEKLAALTAG
0	3		K404-a	QAFFSSGkNKAALEA
0	1		K404	QAFFSSGKNKAALEA
0	43		Y449-p	ALLHGNCyNRWFDKS
0	1		S533-p	CQAVIESsyQVAKAL
0	34		Y534-p	QAVIESsyQVAKALA
0	7		Y547	LADDVELYCFQFLPF
0	1		E621	AFVQAMMEGSHTKAD
0	1		K626	MMEGSHTKADLRDLF
0	1		S743	ISSKFSSSETNAQRF
0	1		Q766	LDIADLFQVPKAYS_

	CPT1B iso3
Y32	REALKHVYLSGINSW
S34	ALKHVYLSGINSWKK
S38	VYLSGINSWKKRLIR
K40	LSGINSWKKRLIRIK
K41	SGINSWKKRLIRIKN
K47	KKRLIRIKNGILRGV
T171	PMLYSFQTSLPKLPV
L206	EEYYRMELLAKEFQD
K209	YRMELLAKEFQDKTA
K321	NTTRIPGKDTDVLQH
S330	TDVLQHLSDSRHVAV
K345	YHKGRFFKLWLYEGA
Y349	RFFKLWLYEGARLLS
-	gap
-	gap
-	gap
Y368	ALLHGNCYNRWFDKS
S452	CQAVIESSYQVAKAL
Y453	QAVIESSYQVAKALA
Y466	LADDVELYCFQFLPF
E540	AFVQAMMEGSHTKAD
K545	MMEGSHTKADLRDLF
S662	ISSKFSSSETNAQRF
Q685	LDIADLFQVPKAYS_

	mouse
Y32	REALRHIYLSGINSW
S34	ALRHIYLSGINSWKk
S38	IYLSGINSWKkRLIR
K40	LSGINSWKkRLIRIk
K41-a	SGINSWKkRLIRIkN
K47-u	KkRLIRIkNGILRGV
T171	PMLYSFQTSLPKLPV
T206-p	EAYYRMEtLAkEFQD
K209-u	YRMEtLAkEFQDKTA
K321-u	NTTRIPGkETDLLQH
S330	TDLLQHLSESRHVAV
K345	YHKGRFFKVWLyEGS
Y349-p	RFFKVWLyEGSRLLK
K380-u	PPQPGEEkLAALTAG
K404-a	QTFFSSGkNKMSLDA
K404-u	QTFFSSGkNKMSLDA
Y449-p	ALLHGNCyNRWFDKS
S533	CREAIENSyQVAKAL
Y534-p	REAIENSyQVAKALA
Y547	LADDVELYCFQFLPF
K621-u	AFVQAMMkGSHKkQD
K626-u	MMkGSHKkQDLQDLF
S743	ISSKYSSSETNAQRF
K766-u	LDIAELFkISKTDS_

	rat
Y32	REALRHIYLSGINSW
S34	ALRHIYLSGINSWKK
S38	IYLSGINSWKKRLIR
K40	LSGINSWKKRLIRIK
K41	SGINSWKKRLIRIKN
K47	KKRLIRIKNGILRGV
T171	PMLYSFQTSLPKLPV
S206	EAYFRMESLAKEFQD
K209	FRMESLAKEFQDKIA
K321	NTTRIPGKETDLLQH
S330	TDLLQHLSESRHVAV
K345	YHKGRFFKVWLYEGS
Y349	RFFKVWLYEGSCLLK
K380	PPQPGEEKLAALTAG
K404	QKFFSSGKNKMSLDT
K404	QKFFSSGKNKMSLDT
Y449	SLLHGNCYNRWFDKS
S533	CQTAIENSYQVAKAL
Y534	QTAIENSYQVAKALA
Y547-p	LADDVELyCFQFLPF
T621	AFVRAMMTGSHKKQD
K626	MMTGSHKKQDLQDLF
S743-p	VSSKLSSsETNALRF
K766	LDIADLFKISKTDS_

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