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Protein Page:
MYBPC3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MYBPC3 Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. Note: This description may include information from UniProtKB.
Protein type: Myosin binding protein
Cellular Component: sarcomere; striated muscle thick filament; cytosol; A band
Molecular Function: identical protein binding; ATPase activator activity; myosin binding; structural constituent of muscle; metal ion binding; titin binding; actin binding; myosin heavy chain binding
Biological Process: heart morphogenesis; regulation of heart rate; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; cell adhesion; myosin filament assembly; cardiac muscle contraction; muscle filament sliding
Reference #:  Q14896 (UniProtKB)
Alt. Names/Synonyms: C-protein, cardiac muscle isoform; Cardiac MyBP-C; CMH4; DKFZp779E1762; FHC; MYBP-C; MYBPC3; myosin binding protein C, cardiac; myosin-binding protein C, cardiac; Myosin-binding protein C, cardiac-type; MYPC3
Gene Symbols: MYBPC3
Molecular weight: 140,762 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Select Structure to View Below

MYBPC3

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S275‑p, S284‑p, S304‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S18-p AFSKKPRsVEVAAGS
1 0 S25 sVEVAAGSPAVFEAE
1 0 T33 PAVFEAETERAGVKV
1 2 S47 VRWQRGGSDISASNK
1 0 S50 QRGGSDISASNKYGL
1 0 T65 ATEGTRHTLTVREVG
1 1 G72 TLTVREVGPADQGsy
0 1 S78-p VGPADQGsyAVIAGS
0 1 Y79-p GPADQGsyAVIAGSs
0 2 S86-p yAVIAGSsKVKFDLK
0 1 K87 AVIAGSsKVKFDLKV
0 1 P102 IEAEKAEPMLAPAPA
1 1 A105 EKAEPMLAPAPAPAE
1 1 S133-p ELGESAPsPKGSSSA
0 1 K185 VAGASLLKPPVVKWF
1 4 S212-p QHLQLHDsyDRASKV
1 39 Y213-p HLQLHDsyDRASKVY
0 2 T274-p LLSAFRRtsLAGGGR
13 16 S275-p LSAFRRtsLAGGGRR
0 2 I283 LAGGGRRIsDsHEDt
17 28 S284-p AGGGRRIsDsHEDtG
0 4 S286-p GGRRIsDsHEDtGIL
0 1 T290-p IsDsHEDtGILDFSS
1 1 I292 DsHEDtGILDFSSLL
0 2 S297 tGILDFSSLLKKRDs
15 1 S304-p SLLKKRDsFRTPRDs
4 8 S311-p sFRTPRDsKLEAPAE
0 1 K312 FRTPRDsKLEAPAEE
1 0 S331 ILRQAPPSEYERIAF
0 3 Y340-p YERIAFQyGVTDLRG
0 79 Y373-p QKKLEPAyQVSKGHK
0 1 K380 yQVSKGHKIRLTVEL
1 0 T384 KGHKIRLTVELADHD
0 1 K395 ADHDAEVKWLKNGQE
0 1 K398 DAEVKWLKNGQEIQM
1 0 S414 GSKYIFESIGAkRTL
0 37 K418-a IFESIGAkRTLTIsQ
0 1 K418 IFESIGAKRTLTIsQ
0 1 S424-p AkRTLTIsQCsLADD
0 3 S427-p TLTIsQCsLADDAAY
0 1 K450 CSTELFVKEPPVLIT
0 1 P459 PPVLITRPLEDQLVM
0 1 K488 GAQVKWLKDGVELTR
0 1 K543 AELIVQEKKLEVyQs
0 1 K544 ELIVQEKKLEVyQsI
0 82 Y548-p QEKKLEVyQsIADLM
0 9 S550-p KKLEVyQsIADLMVG
0 1 K565 AKDQAVFKCEVSDEN
0 1 S588-p GKELVPDsRIKVSHI
0 1 T602-p IGRVHKLtIDDVtPA
0 1 T607-p KLtIDDVtPADEADY
0 1 K692 KAITQGNKAPARPAP
0 1 S708-p APEDTGDsDEWVFDK
0 1 K715 sDEWVFDKKLLCETE
0 1 K716 DEWVFDKKLLCETEG
0 1 K932 EHTSILVKDLPTGAR
0 1 T959 PGAPVTTTEPVTVQE
0 1 K1000 LLIPFQGKPRPQVTW
0 1 S1024 EEVSIRNSPTDTILF
0 1 V1038 FIRAARRVHSGTyQV
0 2 Y1043-p RRVHSGTyQVTVRIE
0 1 S1067-p LQVVDKPsPPQDLRV
0 8 Y1119-p WFTVLEHyRRTHCVV
0 3 Y1135-p ELIIGNGyyFRVFSQ
0 38 Y1136-p LIIGNGyyFRVFSQN
0 1 R1150 NMVGFSDRAATTKEP
0 2 K1155 SDRAATTKEPVFIPR
0 1 N1171 GITYEPPNyKALDFS
0 6 Y1172-p ITYEPPNyKALDFSE
0 1 K1173 TYEPPNyKALDFSEA
0 1 K1216 KPKISWFKNGLDLGE
0 1 K1232 ARFRMFSKQGVLTLE
0 1 R1241 GVLTLEIRKPCPFDG
0 1 K1242 VLTLEIRKPCPFDGG
  mouse

 
S18 AFNKKPRSAEVTAGs
S25-p SAEVTAGsAAVFEAE
T33-p AAVFEAEtERSGVMV
S47-p VRWQRDGsDItANDK
T50-p QRDGsDItANDKYGL
T65-p AAEGKRHtLTVRDAs
S72-p tLTVRDAsPDDQGSy
S78 AsPDDQGSyAVIAGS
Y79-p sPDDQGSyAVIAGSs
S86-p yAVIAGSskVKFDLK
K87-u AVIAGSskVKFDLKV
K102-u TEPAPPEkAEsEVAP
S105-p APPEkAEsEVAPGAP
S128 ELEESVSSPEGSVSV
K183-u VAGASLLkPPVVKWF
S210-p QHLQLHDsyDRASKV
Y211-p HLQLHDsyDRASKVY
T272-p LRSAFRRtsLAGAGR
S273-p RSAFRRtsLAGAGRR
T281-p LAGAGRRtsDsHEDA
S282-p AGAGRRtsDsHEDAG
S284-p AGRRtsDsHEDAGtP
A288 tsDsHEDAGtPDFSs
T290-p DsHEDAGtPDFSsLL
S295-p AGtPDFSsLLKKRDs
S302-p sLLKKRDsFRRDskL
S307-p RDsFRRDskLEAPAE
K308-u DsFRRDskLEAPAEE
S327-p ILRQAPPsEYERIAF
H336 YERIAFQHGVEACHR
Y369-p QKKLEPAyQVNKGHk
K376-u yQVNKGHkIRLtVEL
T380-p KGHkIRLtVELADPD
K391-u ADPDAEVkWLkNGQE
K394-u DAEVkWLkNGQEIQM
S410-p GSKYIFEsVGAkRTL
K414 IFEsVGAKRTLTIsQ
K414-u IFEsVGAkRTLTIsQ
S420-p AkRTLTIsQCsLADD
S423-p TLTIsQCsLADDAAY
K446-u CSTELFVkEPPVLIT
S455-p PPVLITRsLEDQLVM
K484-u GAQVKWLkDGVELTR
K539-u AELIVQEkkLEVyQs
K540-u ELIVQEkkLEVyQsI
Y544-p QEkkLEVyQsIADLA
S546-p kkLEVyQsIADLAVG
K561-u AKDQAVFkCEVSDEN
N584 GKELVPDNRIKVSHI
T598 IGRVHKLTIDDVTPA
T603 KLTIDDVTPADEADY
K688-u KTVTQGKkASAGPHP
D704 APEDAGADEEWVFDk
K711-u DEEWVFDkkLLCETE
K712-u EEWVFDkkLLCETEG
K928-u ERRSMLVkDLPTGAR
K955-u PGGPIVTkEPVTVQE
K996-u LLIPFQGkPRPQVTW
S1020-p EEVSIRNsPTDTILF
T1034-p FIRAARRtHSGTYQV
Y1039 RRtHSGTYQVTVRIE
S1063 LQIVDKPSPPQDIRI
Y1115 WFTVLEHYRRTHCVV
Y1131 ELIIGNGYYFRVFSH
Y1132 LIIGNGYYFRVFSHN
K1146-u NMVGSSDkAAATkEP
K1151-u SDkAAATkEPVFIPR
K1167-u GITYEPPkYkALDFS
Y1168 ITYEPPkYkALDFSE
K1169-u TYEPPkYkALDFSEA
K1212-u KPKISWFkNGLDLGE
K1228-u ARFRMFCkQGVLTLE
R1237-m1 GVLTLEIrkPCPYDG
K1238-u VLTLEIrkPCPYDGG
  rat

 
S18 AFTKKPRSVEVTAGS
S25 SVEVTAGSAAVFEAE
T33 AAVFEAETERSGLKV
S47 VQWQRDGSDIAANDK
A50 QRDGSDIAANDKYGL
T65 AAEGKRHTLTVRDVG
G72 TLTVRDVGPDDQGSY
S78 VGPDDQGSYAVIAGS
Y79 GPDDQGSYAVIAGSS
S86 YAVIAGSSKVKFDLK
K87 AVIAGSSKVKFDLKV
K102 TEPAPPEKAESAVAP
S105 APPEKAESAVAPTSM
S134 QLEGNVSSPEGSVSV
K189 VAGASLLKPPVVKWF
S216 QHLQLHDSYDRASKV
Y217 HLQLHDSYDRASKVY
T278 LRSAFRRTsLAGTGR
S279-p RSAFRRTsLAGTGRR
T287 LAGTGRRTsDSHEDA
S288-p AGTGRRTsDSHEDAG
S290 TGRRTsDSHEDAGTL
A294 TsDSHEDAGTLDFSS
T296 DSHEDAGTLDFSSLL
S301 AGTLDFSSLLKKSsF
S307-p SSLLKKSsFRRDsKL
S312-p KSsFRRDsKLEAPAE
K313 SsFRRDsKLEAPAEE
S332 ILRQAPPSEYERIAF
H341 YERIAFQHGVTDLRG
Y374-p QKKLEPAyQVNKGHK
K381 yQVNKGHKIRLTVEL
T385 KGHKIRLTVELADPD
K396 ADPDAEVKWLKNGQE
K399 DAEVKWLKNGQEIQM
S414 SGRYIFESIGAKRTL
K418 IFESIGAKRTLTISQ
K418 IFESIGAKRTLTISQ
S424 AKRTLTISQCSLADD
S427 TLTISQCSLADDAAY
K450 CSTELFVKEPPVLIT
S459 PPVLITRSLEDQLVM
K488 GAQVKWLKDGVELTR
K543 AELIVQEKKLEVyQS
K544 ELIVQEKKLEVyQSI
Y548-p QEKKLEVyQSIADLA
S550 KKLEVyQSIADLAVG
K565 AKDQAVFKCEVSDEN
N588 GKELVPDNRIKVSHI
T602 IGRVHKLTIDDVTPA
T607 KLTIDDVTPADEADY
K692 KTITQGKKASAGPPP
D708 APEDAGADEEWVFDK
K715 DEEWVFDKKLLCETE
K716 EEWVFDKKLLCETEG
K932 ERTSLLVKDLPTGAR
K959 PGGPIITKEPVTVQE
K1000 LLIPFQGKPRPQVTW
S1024 EEVSIRNSPTDTILF
T1038 FIRAAHRTHSGTyQV
Y1043-p HRTHSGTyQVTVRIE
S1067 LQIVDKPSPPLDIRV
Y1119 WFTVLEHYRQTHCVV
Y1135 ELIIGNGYYFRVFSH
Y1136 LIIGNGYYFRVFSHN
R1150 NMVGSSDRAAATKEP
K1155 SDRAAATKEPIFIPR
K1171 GITYEPPKYKALDFS
Y1172 ITYEPPKYKALDFSE
K1173 TYEPPKYKALDFSEA
K1216 KPKISWFKNGLDLGE
K1232 ARFRMFCKQGVLTLE
R1241 GVLTLEIRKPCPYDG
K1242 VLTLEIRKPCPYDGG
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