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Protein Page:
CDC45L (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDC45L Required for initiation of chromosomal DNA replication. Associated with ORC2. Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. Belongs to the CDC45 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; DNA replication initiation; mitotic cell cycle; DNA strand elongation during DNA replication; DNA replication checkpoint; DNA replication; G1/S transition of mitotic cell cycle
Reference #:  O75419 (UniProtKB)
Alt. Names/Synonyms: CC45L; Cdc45; CDC45 (cell division cycle 45, S.cerevisiae, homolog)-like; CDC45 cell division cycle 45 homolog (S. cerevisiae); CDC45 cell division cycle 45-like; CDC45-related protein; CDC45L; CDC45L2; cell division cycle 45-like 2; human CDC45; PORC-PI-1
Gene Symbols: CDC45
Molecular weight: 65,569 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDC45L

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K8-ub MFVSDFRkEFYEVVQ
0 1 S25 RVLLFVASDVDALCA
0 1 Y130-p DDLEVPAyEDIFRDE
0 3 S144-p EEEDEEHsGNDsDGS
0 1 N146 EDEEHsGNDsDGSEP
0 1 S148-p EEHsGNDsDGSEPSE
0 7 T168-p EEEIVEQtMRRRQRR
0 2 K237-ub QDKITQMkYVTDVGV
0 3 T262-p RNEDEENtLSVDCTR
0 2 K323-ub ADMGLPLkQVkQkFQ
0 1 K326-ub GLPLkQVkQkFQAMD
0 1 K328-ub PLkQVkQkFQAMDIS
0 3 K337-ub QAMDISLkENLREMI
0 1 K350-ub MIEESANkFGMKDMR
0 1 T360-p MKDMRVQtFSIHFGF
0 1 K411-ub LSRSNLDkLyHGLEL
0 1 Y413-p RSNLDkLyHGLELAK
0 2 S465 MLFSRPASLSLLSKH
0 1 T513-p VVGIPPEtDSSDRKN
0 9 K528-ub FFGRAFEkAAESTSS
  mouse

 
K8 MFVTDFRKEFYETVH
S25-p RVLLFVAsDVDALCA
Y130 DDLEVPAYDDIFRDE
S144-p EAEDEDLsDsDGDGS
S146-p EDEDLsDsDGDGSEP
G148 EDLsDsDGDGSEPSE
N168 EEEIVERNRKRRQRR
K237 HDKITQMKYVTDVGI
M262 RNEAEENMLSVDCTR
K323 ADMGLPLKQVKQKFQ
K326 GLPLKQVKQKFQSMD
K328 PLKQVKQKFQSMDVS
K337 QSMDVSLKGNLREMI
K350 MIEESANKFGMKDMR
T360 MKDMRVQTFSIQFGF
K411 LSRSNLDKLYLGLEL
Y413 RSNLDKLYLGLELAK
S465-p TLFSKPAsLSLLSRH
T513 VVGIPPETDSSDRKN
K528 FFGRAFEKAAESTSS
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