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Protein Page:
ECGF1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ECGF1 May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Note: This description may include information from UniProtKB.
Protein type: Phosphorylase; DNA replication; Xenobiotic Metabolism - drug metabolism - other enzymes; Motility/polarity/chemotaxis; Cytokine; Transferase; Nucleotide Metabolism - pyrimidine; EC 2.4.2.4
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cytosol
Molecular Function: thymidine phosphorylase activity; growth factor activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity; platelet-derived growth factor receptor binding
Biological Process: pyrimidine nucleoside catabolic process; mitochondrial genome maintenance; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleotide metabolic process; pyrimidine nucleoside salvage; angiogenesis; DNA replication; cell differentiation; chemotaxis
Reference #:  P19971 (UniProtKB)
Alt. Names/Synonyms: ECGF1; endothelial cell growth factor 1 (platelet-derived); Gliostatin; hPD-ECGF; MNGIE; PD-ECGF; PDECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; TYMP; TYPH
Gene Symbols: TYMP
Molecular weight: 49,955 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ECGF1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6-p __MAALMtPGTGAPP
0 4 S50-p KRDGGRLsEADIRGF
0 1 K115 WRQQLVDKHSTGGVG
0 1 K221 ITASILSKKLVEGLS
0 1 T271-p LRVAAALtAMDkPLG
0 1 K275-ac AALtAMDkPLGRCVG
  mouse

 
- under review  
R36 KRDGGHLREADIRNF
K101-ub WHQQLVDkHSTGGVG
K207-ub ITASILSkKAVEGLS
T257 LKVAAALTAMDNPLG
N261 AALTAMDNPLGRSVG
  rat

 
- under review  
S43 KRNGGHLSEADIRNF
K108 WHQQLVDKHSTGGVG
K214 ITASILSKKAVEGLS
T264 LQVAAALTAMDNPLG
N268 AALTAMDNPLGRNVG
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