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ECGF1 (human)

Overview ECGF1 May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine; DNA replication; Phosphorylase; Transferase; EC 2.4.2.4; Cytokine; Xenobiotic Metabolism - drug metabolism - other enzymes Cellular Component: cytosol Molecular Function: thymidine phosphorylase activity; growth factor activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity; platelet-derived growth factor receptor binding Biological Process: mitochondrial genome maintenance; pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleotide metabolic process; pyrimidine nucleoside salvage; angiogenesis; cell differentiation; DNA replication; chemotaxis Reference #:  P19971 (UniProtKB) Alt. Names/Synonyms: ECGF1; endothelial cell growth factor 1 (platelet-derived); Gliostatin; hPD-ECGF; MNGIE; PD-ECGF; PDECGF; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP; TYMP; TYPH Gene Symbols: TYMP Molecular weight: 49,955 Da Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ECGF1 1UOU - A=10-482 (human) 2J0F - A/B/C/D=1-482 (human) 2WK5 - A/D/C/B=1-482 (human) 2WK6 - A/B=1-482 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1UOU 2J0F 2WK5 2WK6  |  ENZYME  |  Phospho3D  |  DISEASE 131222 603041  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	4		S50-p	KRDGGRLsEADIRGF
0	1		K115	WRQQLVDKHSTGGVG
0	1		K221	ITASILSKKLVEGLS
0	1		T271-p	LRVAAALtAMDkPLG
0	1		K275-a	AALtAMDkPLGRCVG

	mouse
R36	KRDGGHLREADIRNF
K101-u	WHQQLVDkHSTGGVG
K207-u	ITASILSkKAVEGLS
T257	LKVAAALTAMDNPLG
N261	AALTAMDNPLGRSVG

	rat
S43	KRNGGHLSEADIRNF
K108	WHQQLVDKHSTGGVG
K214	ITASILSKKAVEGLS
T264	LQVAAALTAMDNPLG
N268	AALTAMDNPLGRNVG

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