Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
BRE (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BRE Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect. Belongs to the BRE family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Cytokine; Apoptosis; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 2p23.2
Cellular Component: cytoplasm; nuclear ubiquitin ligase complex; nucleus
Molecular Function: protein binding; peroxisome targeting sequence binding; polyubiquitin binding; tumor necrosis factor receptor binding
Biological Process: positive regulation of DNA repair; apoptosis; double-strand break repair; chromatin modification; response to ionizing radiation; signal transduction; G2/M transition DNA damage checkpoint; response to DNA damage stimulus
Reference #:  Q9NXR7 (UniProtKB)
Alt. Names/Synonyms: brain and reproductive organ-expressed (TNFRSF1A modulator); Brain and reproductive organ-expressed protein; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; BRCC4; BRCC45; BRE
Gene Symbols: BRE
Molecular weight: 43,552 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRE

Protein Structure Not Found.


STRING  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 6 S2-p ______MsPEVALNR
0 6 S15-p NRISPMLsPFISSVV
0 1 K26 SSVVRNGKVGLDATN
0 2 K41-ub CLRITDLkSGCTSLT
0 1 K162-ub MEIYAGKkNNWTGEF
0 7 K176-ub FSARFLLkLPVDFSN
0 1 S222 VYPKLYLSPRIEHAL
0 1 Y249 GGGCLIDYVPQVCHL
0 5 Y263-p LLTNKVQyVIQGYHk
0 1 K270-ac yVIQGYHkRREYIAA
0 1 S350-p AQKNYPYsPRWDGNE
0 1 K367-ub KRAKAYFkTFVPQFQ
0 1 K382-ac EAAFANGkL______
0 46 K382-ub EAAFANGkL______
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
  BRE iso3  
S2 ______MSPEVALNR
S15 NRISPMLSPFISSVV
K26 SSVVRNGKVGLDATN
K41 CLRITDLKSGCTSLT
K162 MEIYAGKKNNWTGEF
K176 FSARFLLKLPVDFSN
S222 VYPKLYLSPRIEHAL
Y249 GGGCLIDYVPQVCHL
Y263 LLTNKVQYVIQGYHK
K270 YVIQGYHKRREYIAA
S350 AQKNYPYSPRWDGNE
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S374-p QHLPMESsRKHQS__
  BRE iso4  
S2 ______MSPEVALNR
S15 NRISPMLSPFISSVV
K26 SSVVRNGKVGLDATN
K41 CLRITDLKSGCTSLT
K162 MEIYAGKKNNWTGEF
K176 FSARFLLKLPVDFSN
S222 VYPKLYLSPRIEHAL
Y249 GGGCLIDYVPQVCHL
Y263 LLTNKVQYVIQGYHK
K270 YVIQGYHKRREYIAA
S350 AQKNYPYSPRWDGNE
- gap
- gap
- gap
S366-p AKRAKREsNRDGEEs
S373-p sNRDGEEsssA____
S374-p NRDGEEsssA_____
S375-p RDGEEsssA______
- gap
  mouse

► Hide Isoforms
 
S2-p ______MsPEIALNR
S15-p NRISPMLsPFISSVV
K26-ac SSVVRNGkVGLDATN
K41-ub CLRITDLkSGCTSLT
K162 MEIYAGKKNNWTGEF
K176 FSARFLLKLPVDFSN
S222-p VYPKLYLsPRIEHAL
Y249-p GGGCLIDyVPQVCHL
Y263-p LLTNKVQyVIQGYHK
K270 yVIQGYHKRREYIAA
S350 AQKNYPYSPRWDGNE
K367 KRAKAYFKTFVPQFQ
K382 EAAFANGKL______
K382-ub EAAFANGkL______
- gap
- gap
- gap
- gap
- gap
  BRE iso1  
S2 ______MSPEIALNR
S15 NRISPMLSPFISSVV
K26 SSVVRNGKIHEKGPS
- gap
K199 MEIYAGKKNNWTGEF
K213 FSARFLLKLPVDFSN
S259 VYPKLYLSPRIEHAL
Y286 GGGCLIDYVPQVCHL
Y300 LLTNKVQYVIQGYHK
K307 YVIQGYHKRREYIAA
S387 AQKNYPYSPRWDGNE
K404 KRAKAYFKTFVPQFQ
K419 EAAFANGKL______
K419 EAAFANGKL______
- gap
- gap
- gap
- gap
- gap
  rat

 
S2-p ______MsPEIALNR
S15 NRISPMLSPFISSVV
K26 SSVVRNGKVGLDATN
K41 CLRITDLKSGCTSLT
K162 MEIYAGKKNNWTGEF
K176 FSARFLLKLPVDFSN
S222 VYPKLYLSPRIEHAL
Y249 GGGCLIDYVPQVCHL
Y263 LLTNKVQYVIQGYHK
K270 YVIQGYHKRREYIAA
S350 AQKNYPYSPRWDGNE
K367 KRAKAYFKTFVPQFQ
K382 EAAFANGKL______
K382 EAAFANGKL______
- gap
- gap
- gap
- gap
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.