Home

CTSD (human)

Overview CTSD Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Autophagy; EC 3.4.23.5; Protease Cellular Component: extracellular matrix; lysosomal lumen; extracellular space; lysosome; extracellular region; melanosome Molecular Function: aspartic-type endopeptidase activity Biological Process: cell death; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis Reference #:  P07339 (UniProtKB) Alt. Names/Synonyms: CATD; Cathepsin D; Cathepsin D heavy chain; Cathepsin D light chain; ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; CTSD; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311 Gene Symbols: CTSD Molecular weight: 44,552 Da Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CTSD 1LYA - A/C=65-161, B/D=170-410 (human) 1LYB - A/C=65-161, B/D=170-410 (human) 1LYW - A/C/E/G=65-161, B/D/F/H=170-410 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1LYA 1LYB 1LYW  |  ENZYME  |  Phospho3D  |  DISEASE 116840 610127  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K28-u	LVRIPLHkFTSIRRT
0	1		S42	TMSEVGGSVEDLIAk
0	1		K49-u	SVEDLIAkGPVSkYS
0	1		K54-u	IAkGPVSkYSQAVPA
0	1		V62	YSQAVPAVtEGPIPE
0	1		T63-ga	SQAVPAVtEGPIPEV
0	1		R176	LGGVKVERQVFGEAT
0	2		K184-u	QVFGEATkQPGITFI
0	1		S230	LVDQNIFSFYLSRDP
0	1		Y232	DQNIFSFYLSRDPDA
0	1		T250	GELMLGGTDSkYYKG
0	1		S252	LMLGGTDSkYYKGSL
0	1		K253-u	MLGGTDSkYYKGSLS
0	1		Y325-p	VPLIQGEyMIPCEKV
0	1		T339-p	VSTLPAItLKLGGKG
0	1		K341	TLPAItLKLGGKGyk
0	2		Y347-p	LKLGGKGykLSPEDy
0	1		K348-u	KLGGKGykLSPEDyT
0	2		Y354-p	ykLSPEDyTLKVSQA

	mouse ► Hide Isoforms
K28	IIRIPLRKFTSIRRT
S42-p	TMTEVGGsVEDLILK
K49	sVEDLILKGPITKYS
K54	ILKGPITKYSMQSSP
K62-u	YSMQSSPkTTEPVSE
-	under review
K174-u	ARGIKVEkQIFGEAT
K182-u	QIFGEATkQPGIVFV
S228-p	LVDKNIFsFyLNRDP
Y230-p	DKNIFsFyLNRDPEG
T248-p	GELMLGGtDsKYYHG
S250-p	LMLGGtDsKYYHGEL
K251	MLGGtDsKYYHGELS
Y323	VPLIQGEYMIPCEKV
Y337	VSSLPTVYLkLGGKN
K339-u	SLPTVYLkLGGKNYE
Y345	LkLGGKNYELHPDKY
E346	kLGGKNYELHPDKYI
Y352	YELHPDKYILKVSQG

	CTSD iso3
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
K43	ARGIKVEKQIFGEAT
K51	QIFGEATKQPGIVFV
S97	LVDKNIFSFYLNRDP
Y99	DKNIFSFYLNRDPEG
T117	GELMLGGTDSKYYHG
S119	LMLGGTDSKYYHGEL
K120	MLGGTDSKYYHGELS
Y192	VPLIQGEYMIPCEKV
Y206	VSSLPTVYLKLGGKN
K208	SLPTVYLKLGGKNYE
Y214	LKLGGKNYELHPDKY
E215	KLGGKNYELHPDKYI
Y221	YELHPDKYILKAQGP

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.