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Protein Page:
CTSD (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CTSD Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.23.5; Autophagy; Protease; Motility/polarity/chemotaxis
Cellular Component: extracellular matrix; lysosomal lumen; extracellular space; mitochondrion; lysosome; melanosome; extracellular region
Molecular Function: protein binding; aspartic-type endopeptidase activity
Biological Process: cell death; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis; autophagic vacuole formation
Reference #:  P07339 (UniProtKB)
Alt. Names/Synonyms: CATD; Cathepsin D; Cathepsin D heavy chain; Cathepsin D light chain; ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; CTSD; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311
Gene Symbols: CTSD
Molecular weight: 44,552 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTSD

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K28-u LVRIPLHkFTSIRRT
0 1 K54-u IAKGPVSkYSQAVPA
0 1 - gap
0 1 T63-ga SQAVPAVtEGPIPEV
0 1 R176 LGGVKVERQVFGEAT
0 2 K184-u QVFGEATkQPGITFI
0 1 S230 LVDQNIFSFYLSRDP
0 1 Y232 DQNIFSFYLSRDPDA
0 1 T250 GELMLGGTDSkYYKG
0 1 S252 LMLGGTDSkYYKGSL
0 1 K253-u MLGGTDSkYYKGSLS
0 1 T339-p VSTLPAItLKLGGKG
0 1 K341 TLPAItLKLGGKGyk
0 2 Y347-p LKLGGKGykLSPEDy
0 1 K348-u KLGGKGykLSPEDyT
0 2 Y354-p ykLSPEDyTLKVSQA
  mouse

► Hide Isoforms
 
K28 IIRIPLRKFTSIRRT
K54 ILKGPITKYSMQSSP
K62-u YSMQSSPkTTEPVSE
T63 SMQSSPkTTEPVSEL
K174-u ARGIKVEkQIFGEAT
K182-u QIFGEATkQPGIVFV
S228-p LVDKNIFsFyLNRDP
Y230-p DKNIFsFyLNRDPEG
T248-p GELMLGGtDsKYYHG
S250-p LMLGGtDsKYYHGEL
K251 MLGGtDsKYYHGELS
Y337 VSSLPTVYLkLGGKN
K339-u SLPTVYLkLGGKNYE
Y345 LkLGGKNYELHPDKY
E346 kLGGKNYELHPDKYI
Y352 YELHPDKYILKVSQG
  CTSD iso3  
- gap
- gap
- gap
- gap
K43 ARGIKVEKQIFGEAT
K51 QIFGEATKQPGIVFV
S97 LVDKNIFSFYLNRDP
Y99 DKNIFSFYLNRDPEG
T117 GELMLGGTDSKYYHG
S119 LMLGGTDSKYYHGEL
K120 MLGGTDSKYYHGELS
Y206 VSSLPTVYLKLGGKN
K208 SLPTVYLKLGGKNYE
Y214 LKLGGKNYELHPDKY
E215 KLGGKNYELHPDKYI
Y221 YELHPDKYILKAQGP
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