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Protein Page:
SYP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SYP Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1. Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. Belongs to the synaptophysin/synaptobrevin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle protein; Membrane protein, multi-pass
Cellular Component: presynaptic membrane; neuron projection; protein complex; presynaptic active zone; excitatory synapse; cell junction; integral to synaptic vesicle membrane
Molecular Function: identical protein binding; transporter activity; syntaxin-1 binding; cholesterol binding; protein complex binding; SH2 domain binding
Biological Process: regulation of long-term neuronal synaptic plasticity; synaptic vesicle maturation; synaptic vesicle membrane organization and biogenesis; endocytosis; regulation of short-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity
Reference #:  P08247 (UniProtKB)
Alt. Names/Synonyms: Major synaptic vesicle protein p38; MRXSYP; Synaptophysin; SYP; SYPH
Gene Symbols: SYP
Molecular weight: 33,845 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SYP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 137 Y81-p PFRLHQVyFDAPTCR
0 2 T86 QVyFDAPTCRGGTTK
0 1 R88 yFDAPTCRGGTTKVF
0 1 T186 EMPVCRQTGNTCKEL
0 1 Y250-p QPAPGDAyGDAGYGQ
1 1 Y268 GYGPQDSYGPQGGYQ
1 1 Y278 QGGYQPDYGQPAGSG
  mouse

 
Y81-p PFRLHQVyFDAPsCV
S86-p QVyFDAPsCVkGGTT
K89-ub FDAPsCVkGGTTKIF
T187-p EMPMCRQtGNTCKEL
Y251 QPAPGDAYGDAGYGQ
Y269-p GYGPQDSyGPQGGYQ
Y279-p QGGYQPDyGQPASGG
  rat

 
Y75-p PFRLHQVyFDAPSCV
S80 QVyFDAPSCVKGGTT
K83 FDAPSCVKGGTTKIF
T181 EMPMCRQTGNTCKEL
Y245 QPAPGDAYGDAGYGQ
Y263-p GYGPQDSyGPQGGYQ
Y273-p QGGYQPDyGQPASGG
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