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Protein Page:
SYP (human)

Overview
SYP Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Homohexamer or homotetramer. Interacts with SRCIN1. Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype. Belongs to the synaptophysin/synaptobrevin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle protein; Membrane protein, multi-pass
Cellular Component: presynaptic membrane; protein complex; presynaptic active zone; excitatory synapse; cell junction; integral to synaptic vesicle membrane
Molecular Function: identical protein binding; transporter activity; syntaxin-1 binding; cholesterol binding; protein complex binding; SH2 domain binding
Biological Process: regulation of long-term neuronal synaptic plasticity; synaptic vesicle maturation; synaptic vesicle membrane organization and biogenesis; endocytosis; regulation of short-term neuronal synaptic plasticity; regulation of neuronal synaptic plasticity
Reference #:  P08247 (UniProtKB)
Alt. Names/Synonyms: Major synaptic vesicle protein p38; MRXSYP; Synaptophysin; SYP; SYPH
Gene Symbols: SYP
Molecular weight: 33,845 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SYP

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 129 Y81-p PFRLHQVyFDAPTCR
0 2 T86 QVyFDAPTCRGGTTK
0 1 T186 EMPVCRQTGNTCKEL
0 1 Y250-p QPAPGDAyGDAGYGQ
1 1 Y268 GYGPQDSYGPQGGYQ
1 1 Y278 QGGYQPDYGQPAGSG
  mouse

 
Y81-p PFRLHQVyFDAPsCV
S86-p QVyFDAPsCVKGGTT
T187-p EMPMCRQtGNTCKEL
Y251 QPAPGDAYGDAGYGQ
Y269-p GYGPQDSyGPQGGYQ
Y279-p QGGYQPDyGQPASGG
  rat

 
Y75-p PFRLHQVyFDAPSCV
S80 QVyFDAPSCVKGGTT
T181 EMPMCRQTGNTCKEL
Y245 QPAPGDAYGDAGYGQ
Y263-p GYGPQDSyGPQGGYQ
Y273-p QGGYQPDyGQPASGG
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