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Protein Page:
CNTNAP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CNTNAP2 May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; cell surface; cell soma; membrane; axon; dendrite; early endosome; integral to membrane; perikaryon; axolemma
Molecular Function: enzyme binding
Biological Process: striatum development; limbic system development; adult behavior; clustering of voltage-gated potassium channels; neuron recognition; transmission of nerve impulse; social behavior; thalamus development; brain development; learning; cerebral cortex development; cell adhesion; neurite development
Reference #:  Q9UHC6 (UniProtKB)
Alt. Names/Synonyms: AUTS15; CASPR2; CDFE; Cell recognition molecule Caspr2; CNTNAP2; CNTP2; contactin associated protein-like 2; contactin-associated protein 2; Contactin-associated protein-like 2; DKFZp781D1846; homolog of Drosophila neurexin IV; KIAA0868; NRXN4; PTHSL1
Gene Symbols: CNTNAP2
Molecular weight: 148,167 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CNTNAP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 T100-p KQISAIAtQGRYSSS
0 1 Y183-p IEVYGCSyWADVINF
0 1 T348-p NYNGVNItDLARRKK
0 1 T638-p MTEDKVWtIVsHDLQ
0 1 S641-p DKVWtIVsHDLQMQT
0 2 S852-p FIKLELKsAtEVsFs
0 2 T854-p KLELKsAtEVsFsFD
0 2 S857-p LKsAtEVsFsFDVGN
0 2 S859-p sAtEVsFsFDVGNGP
0 1 T1071-p LLYISSFttDFLAVL
0 1 T1072-p LYISSFttDFLAVLV
0 5 S1303-p NEAKGAEsAEsADAA
0 5 S1306-p KGAEsAEsADAAIMN
  CNTNAP2 iso3  
K16-ub GLGLPADkGRSSGVL
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S195 NEAKGAESAESADAA
S198 KGAESAESADAAIMN
  mouse

 
- gap
T100 KQISAIATQGRYSSS
Y183 AEVYGCAYWADVINF
T348 NYNGVNITDLARRKK
T638 MTEDKVWTIVSHDLQ
S641 DKVWTIVSHDLQMQT
S852 FIKLELKSATEVSFS
T854 KLELKSATEVSFSFD
S857 LKSATEVSFSFDVGN
S859 SATEVSFSFDVGNGP
T1072 LLYVSSLTTDFLAVL
T1073 LYVSSLTTDFLAVLV
S1304-p NEAKGAEsAEsADAA
S1307-p KGAEsAEsADAAIMN
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