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CNTNAP2 (human)

Overview CNTNAP2 May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; cell surface; cell soma; membrane; axon; dendrite; early endosome; integral to membrane; perikaryon; axolemma Molecular Function: enzyme binding; receptor binding Biological Process: striatum development; limbic system development; behavior; clustering of voltage-gated potassium channels; neuron recognition; transmission of nerve impulse; cerebral cortex development; thalamus development; brain development; cell adhesion; signal transduction; neurite development Reference #:  Q9UHC6 (UniProtKB) Alt. Names/Synonyms: AUTS15; CASPR2; CDFE; Cell recognition molecule Caspr2; CNTNAP2; CNTP2; contactin associated protein-like 2; contactin-associated protein 2; Contactin-associated protein-like 2; DKFZp781D1846; homolog of Drosophila neurexin IV; KIAA0868; NRXN4; PTHSL1 Gene Symbols: CNTNAP2 Molecular weight: 148,167 Da Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CNTNAP2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 604569 610042 612100  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		-	gap
0	1		T100-p	KQISAIAtQGRYSSS
0	1		Y183-p	IEVYGCSyWADVINF
0	1		T638-p	MTEDKVWtIVsHDLQ
0	1		S641-p	DKVWtIVsHDLQMQT
0	2		S852-p	FIKLELKsAtEVsFs
0	2		T854-p	KLELKsAtEVsFsFD
0	2		S857-p	LKsAtEVsFsFDVGN
0	2		S859-p	sAtEVsFsFDVGNGP
0	1		T1071-p	LLYISSFttDFLAVL
0	1		T1072-p	LYISSFttDFLAVLV
0	4		S1303-p	NEAKGAEsAEsADAA
0	4		S1306-p	KGAEsAEsADAAIMN

	CNTNAP2 iso3
K16-u	GLGLPADkGRSSGVL
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S195	NEAKGAESAESADAA
S198	KGAESAESADAAIMN

	mouse
-	gap
T100	KQISAIATQGRYSSS
Y183	AEVYGCAYWADVINF
T638	MTEDKVWTIVSHDLQ
S641	DKVWTIVSHDLQMQT
S852	FIKLELKSATEVSFS
T854	KLELKSATEVSFSFD
S857	LKSATEVSFSFDVGN
S859	SATEVSFSFDVGNGP
T1072	LLYVSSLTTDFLAVL
T1073	LYVSSLTTDFLAVLV
S1304-p	NEAKGAEsAEsADAA
S1307-p	KGAEsAEsADAAIMN

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