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MAML2 (human)

Overview MAML2 Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa. Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. Belongs to the mastermind family. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor Cellular Component: nucleoplasm; Golgi apparatus; nuclear speck; nucleus Molecular Function: transcription coactivator activity Biological Process: transcription initiation from RNA polymerase II promoter; Notch signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter Reference #:  Q8IZL2 (UniProtKB) Alt. Names/Synonyms: DKFZp686N0150; KIAA1819; Mam-2; MAM-3; MAM2; MAM3; MAML2; mastermind-like 2 (Drosophila); Mastermind-like protein 2; MGC176701; MLL-MAML2 Gene Symbols: MAML2 Molecular weight: 125,197 Da Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states CST Pathways:  Notch Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MAML2

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S78-p	ESTLQLLsLVQHGQG
0	1		S185-p	RKQVVNLsPANsKRP
0	2		S189-p	VNLsPANsKRPNGFV
0	1		S230-p	NGQSQIMsGtLPMsQ
0	1		T232-p	QSQIMsGtLPMsQAP
0	1		S236-p	MsGtLPMsQAPLRKT
0	1		Y513-p	QSKVMANyMyKAGPS
0	1		Y515-p	KVMANyMyKAGPSAQ

	mouse
S78	ESTMQLLSLVQHGQG
S180	RKQIVNLSPANSKRP
S184	VNLSPANSKRPNGFV
P225	NGQSQMMPGPLTMNQ
P227	QSQMMPGPLTMNQAP
N231	MPGPLTMNQAPLRKT
Y511	QSKAAANYTYKASPS
Y513	KAAANYTYKASPSAQ

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