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Protein Page:
CHKA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CHKA Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. Belongs to the choline/ethanolamine kinase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.1.32; Kinase, other; EC 2.7.1.82; Lipid Metabolism - glycerophospholipid
Cellular Component: cytosol
Molecular Function: choline binding; signal transducer activity; protein homodimerization activity; cholinesterase activity; drug binding; choline kinase activity; ethanolamine kinase activity; ATP binding
Biological Process: choline metabolic process; CDP-choline pathway; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylcholine biosynthetic process; lipid metabolic process; signal transduction; lipid transport; phosphorylation
Reference #:  P35790 (UniProtKB)
Alt. Names/Synonyms: CHETK-alpha; CHK; CHKA; Choline kinase alpha; CK; CKI; EK; Ethanolamine kinase
Gene Symbols: CHKA
Molecular weight: 52,249 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHKA

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 A30 GSGSAAPAPGVGQQR
0 1 P75 PLPQPPPPQPPADEQ
0 1 Y148 RKVLLRLYGAILQMR
0 1 K195-ub AERSLGPkLyGIFPQ
1 0 Y197-p RSLGPkLyGIFPQGR
0 1 T234 EIAEKMATFHGMKMP
0 1 K247-ac MPFNKEPkWLFGTME
1 0 Y333-p LMLIDFEySSYNYRG
0 3 T371-p ANIRKYPtKKQQLHF
0 1 S431-p SIVQAKIssIEFGyM
0 1 S432-p IVQAKIssIEFGyMD
0 1 Y437-p IssIEFGyMDyAQAR
0 1 Y440-p IEFGyMDyAQARFDA
  mouse

► Hide Isoforms
 
T29-p CGGNAAPtPGVGQQR
S71-p LPLPPPPsPPLADEQ
Y144 RKVLLRLYGAILKMR
K191 AERSLGPKLFGIFPQ
F193 RSLGPKLFGIFPQGR
T230-p EIAEKMAtFHGMKMP
K243 MPFNKEPKWLFGTME
Y329 LMLIDFEYSSYNYRG
S367 ANIQKYPSRKQQLHF
S427 SIVQAKISSIEFGYM
S428 IVQAKISSIEFGYME
Y433 ISSIEFGYMEYAQAR
Y436 IEFGYMEYAQARFEA
  CHKA iso3  
T29 CGGNAAPTPGVGQQR
S71 LPLPPPPSPPLADEQ
Y144-p RKVLLRLyGAILKMA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  rat

 
T29 CGGSAAPTPGVGQQR
S71-p LPLPPPPsPPLADEQ
Y144 RKVLLRLYGAILKMR
K191 AERSLGPKLYGIFPQ
Y193 RSLGPKLYGIFPQGR
T230 EIAEKMATFHGMKMP
K243 MPFNKEPKWLFGTME
Y329 LMLIDFEYSSYNYRG
T367 ANIQKYPTRKQQLHF
S427 SIVQAKISSIEFGYM
S428 IVQAKISSIEFGYME
Y433 ISSIEFGYMEYAQAR
Y436 IEFGYMEYAQARFDA
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