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CD8B
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
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Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome; extracellular region; plasma membrane; external side of plasma membrane
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Molecular Function: protein binding; MHC class I protein binding; coreceptor activity
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Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of defense response to virus by virus
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Reference #:
P10966 (UniProtKB)
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| Alt. Names/Synonyms: CD8 antigen, beta polypeptide (p37); CD8 antigen, beta polypeptide 1 (p37); CD8B; CD8b antigen; CD8b molecule; CD8B1; Leu2; Ly3; LYT3; MGC119115; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain |
| Gene Symbols: CD8B |
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Molecular weight: 23,722 Da
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Basal Isoelectric point: 10.03
Predict pI for various phosphorylation states
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