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Protein Page:
CD8B (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD8B Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; extracellular region; plasma membrane; external side of plasma membrane
Molecular Function: protein binding; MHC class I protein binding; coreceptor activity
Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of defense response to virus by virus
Reference #:  P10966 (UniProtKB)
Alt. Names/Synonyms: CD8 antigen, beta polypeptide (p37); CD8 antigen, beta polypeptide 1 (p37); CD8B; CD8b antigen; CD8b molecule; CD8B1; Leu2; Ly3; LYT3; MGC119115; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain
Gene Symbols: CD8B
Molecular weight: 23,722 Da
Basal Isoelectric point: 10.03  Predict pI for various phosphorylation states
Select Structure to View Below

CD8B

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S40-p TNKMVMLsCEAKISL
0 1 K77 LALWDSAKGTIHGEE
1 0 - gap
  CD8B iso3  
S40 TNKMVMLSCEAKISL
K77 LALWDSAKGTIHGEE
- gap
  CD8B iso4  
S40 TNKMVMLSCEAKISL
K77 LALWDSAKGTIHGEE
K215-ub KFNIVCLkISGFTTC
  mouse

 
S40 TNHTAKMSCEVKSIS
K76-ac LASWSSSkGVLYGES
- gap
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