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Protein Page:
CD8B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

CD8B Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; extracellular region; plasma membrane; external side of plasma membrane
Molecular Function: protein binding; MHC class I protein binding; coreceptor activity
Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of defense response to virus by virus
Reference #:  P10966 (UniProtKB)
Alt. Names/Synonyms: CD8 antigen, beta polypeptide (p37); CD8 antigen, beta polypeptide 1 (p37); CD8B; CD8b antigen; CD8b molecule; CD8B1; Leu2; Ly3; LYT3; MGC119115; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain
Gene Symbols: CD8B
Molecular weight: 23,722 Da
Basal Isoelectric point: 10.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


► Hide Isoforms
1 0 - gap
  CD8B iso3  
- gap
  CD8B iso4  

- gap
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