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Protein Page:
CASP4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CASP4 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; Apoptosis; EC 3.4.22.64
Chromosomal Location of Human Ortholog: 11q22.2-q22.3
Cellular Component: endoplasmic reticulum membrane; mitochondrion; cytoplasm
Molecular Function: cysteine-type endopeptidase activity
Biological Process: regulation of apoptosis; apoptosis; regulation of inflammatory response; proteolysis
Reference #:  P49662 (UniProtKB)
Alt. Names/Synonyms: apoptotic cysteine protease Mih1/TX; CASP-4; CASP4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; ICE(rel)-II; ICE(rel)II; ICEREL-II; ICH-2; ICH2; Mih1/TX; Protease ICH-2; Protease TX; TX
Gene Symbols: CASP4
Molecular weight: 43,262 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CASP4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K49-m1 KKKYYDAkTEDkVRV
0 1 K53-m1 YDAkTEDkVRVMADS
0 5 S83-p FFNIDQIsPNKKAHP
0 2 S271-p GELWVRDsPAsLEVA
0 1 S274-p WVRDsPAsLEVASSQ
0 1 T352-p KVQQSFEtPRAKAQM
  mouse

 
- gap
K53 NNAERSDKRWVFVDA
S83 FFSVDPGSHHGEANL
S267 GEMWIRESSKPQLCR
- gap
K348 KVQQSFEKASIHSQM
  cow

 
K49 KKKIYDAKLQDKARV
K53 YDAKLQDKARVLVDS
S83 FLNIDKNSTSIKAPE
S271 GELWVSDSPPALADS
- gap
K352 KVQQSFEKPNVKAQM
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