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CASP4 (human)

Overview CASP4 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.4.22.64; Protease; Apoptosis; EC 3.4.22.-; EC 3.4.22.57 Cellular Component: intracellular Molecular Function: cysteine-type endopeptidase activity Biological Process: apoptosis; induction of apoptosis; proteolysis Reference #:  P49662 (UniProtKB) Alt. Names/Synonyms: apoptotic cysteine protease Mih1/TX; CASP-4; CASP4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; ICE(rel)-II; ICE(rel)II; ICEREL-II; ICH-2; ICH2; Mih1/TX; Protease ICH-2; Protease TX; TX Gene Symbols: CASP4 Molecular weight: 43,262 Da Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CASP4

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME 3.4.22.57 3.4.22.64  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S83-p	FFNIDQIsPNKKAHP

	mouse
S83	FFSVDPGSHHGEANL

	cow
S83	FLNIDKNSTSIKAPE

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