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Protein Page:
LIMS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LIMS1 Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q12.3
Cellular Component: protein complex; focal adhesion; perinuclear region of cytoplasm; plasma membrane; intercellular junction; cytosol
Molecular Function: protein binding; zinc ion binding; protein kinase binding
Biological Process: intercellular junction assembly and maintenance; chordate embryonic development; protein heterooligomerization; cell-matrix adhesion; establishment and/or maintenance of cell polarity; cell aging; regulation of epithelial cell proliferation; establishment of protein localization; cell-cell adhesion; positive regulation of focal adhesion formation; epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; positive regulation of GTPase activity
Reference #:  P48059 (UniProtKB)
Alt. Names/Synonyms: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIMS1; Particularly interesting new Cys-His protein 1; PINCH; PINCH-1; PINCH1; Renal carcinoma antigen NY-REN-48
Gene Symbols: LIMS1
Molecular weight: 37,251 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LIMS1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 16 - gap
0 21 - gap
0 1 - gap
0 1 S7 _MANALASATCERCK
0 1 T9 ANALASATCERCKGG
0 1 K111-ub LADIGFVkNAGRHLC
0 1 Y244 LAYCETHYNQLFGDV
0 1 K290 TKLTLKNKFVEFDMK
0 3 A319 KKRLKKLAEtLGRK_
0 3 T321-p RLKKLAEtLGRK___
  LIMS1 iso4  
- gap
- gap
T2-p ______MtCNMANAL
S11-p NMANALAsAtCERCK
T13-p ANALAsAtCERCKGG
K115 LADIGFVKNAGRHLC
Y248 LAYCETHYNQLFGDV
K294 TKLTLKNKFVEFDMK
A323 KKRLKKLAETLGRK_
T325 RLKKLAETLGRK___
  LIMS1 iso5  
Y15-p ELSHSGLyRRRRDRP
S24-p RRRDRPDsLRVNGLP
- gap
S44 NMANALASATCERCK
T46 ANALASATCERCKGG
K148 LADIGFVKNAGRHLC
Y281 LAYCETHYNQLFGDV
K327 TKLTLKNKFVEFDMK
A356 KKRLKKLAETLGRK_
T358 RLKKLAETLGRK___
  mouse

 
- gap
- gap
- gap
S7 _MANALASATCERCK
T9 ANALASATCERCKGG
K111 LADIGFVKNAGRHLC
Y244-p LAYCETHyNQLFGDV
K290 TKLTLKNKFVEFDMK
S319-p KKRLKKLsETLGRK_
T321 RLKKLsETLGRK___
  rat

 
Y15 ELSQSGLYRRRRERP
S24 RRRERPDSLRVNGLP
- gap
S44 NMANALASATCERCK
T46 ANALASATCERCKGG
K148 LADIGFVKNAGRHLC
Y281 LAYCETHYNQLFGDV
K327-ac TKLTLKNkFVEFDMK
S356-p KKRLKKLsETLGRK_
T358 RLKKLsETLGRK___
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