Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q12.3
Cellular Component: focal adhesion; protein complex; perinuclear region of cytoplasm; plasma membrane; intercellular junction; cytosol
Molecular Function: protein binding; zinc ion binding; protein kinase binding
Biological Process: intercellular junction assembly and maintenance; chordate embryonic development; protein heterooligomerization; cell-matrix adhesion; establishment and/or maintenance of cell polarity; cell aging; regulation of epithelial cell proliferation; cell-cell adhesion; establishment of protein localization; positive regulation of focal adhesion formation; epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; positive regulation of GTPase activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.