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LIMS1
Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold |
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Cellular Component: focal adhesion; perinuclear region of cytoplasm; plasma membrane; cytosol
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Molecular Function: protein binding; zinc ion binding
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Biological Process: cell aging; negative regulation of transcription, DNA-dependent
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Reference #:
P48059 (UniProtKB)
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| Alt. Names/Synonyms: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIMS1; Particularly interesting new Cys-His protein 1; PINCH; PINCH-1; PINCH1; Renal carcinoma antigen NY-REN-48 |
| Gene Symbols: LIMS1 |
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Molecular weight: 37,251 Da
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Basal Isoelectric point: 8.43
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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