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Protein Page:
LIMS1 (human)

Overview
LIMS1 Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: protein complex; focal adhesion; perinuclear region of cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; zinc ion binding
Biological Process: protein heterooligomerization; cell aging; negative regulation of transcription, DNA-dependent
Reference #:  P48059 (UniProtKB)
Alt. Names/Synonyms: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIMS1; Particularly interesting new Cys-His protein 1; PINCH; PINCH-1; PINCH1; Renal carcinoma antigen NY-REN-48
Gene Symbols: LIMS1
Molecular weight: 37,251 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LIMS1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 16 - gap
0 21 - gap
0 1 A319 KKRLKKLAEtLGRK_
0 2 T321-p RLKKLAEtLGRK___
  LIMS1 iso4  
- gap
- gap
A323 KKRLKKLAETLGRK_
T325 RLKKLAETLGRK___
  LIMS1 iso5  
Y15-p ELSHSGLyRRRRDRP
S24-p RRRDRPDsLRVNGLP
A356 KKRLKKLAETLGRK_
T358 RLKKLAETLGRK___
  mouse

 
- gap
- gap
S319-p KKRLKKLsETLGRK_
T321 RLKKLsETLGRK___
  rat

 
Y15 ELSQSGLYRRRRERP
S24 RRRERPDSLRVNGLP
S356 KKRLKKLSETLGRK_
T358 RLKKLSETLGRK___
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