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Protein Page:
BMI1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BMI1 Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. Component of a PRC1-like complex. Interacts with RING1 and RING2. Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Motility/polarity/chemotaxis; Ubiquitin ligase; Ligase; EC 6.3.2.-
Cellular Component: nucleoplasm; cytoplasm; PcG protein complex; nucleus; ubiquitin ligase complex
Molecular Function: protein binding; zinc ion binding
Biological Process: segment specification; positive regulation of fibroblast proliferation; transcription, DNA-dependent; regulation of gene expression; positive regulation of ubiquitin-protein ligase activity; hemopoiesis; chromatin modification; negative regulation of transcription from RNA polymerase II promoter
Reference #:  P35226 (UniProtKB)
Alt. Names/Synonyms: B lymphoma Mo-MLV insertion region 1 homolog; BMI1; BMI1 polycomb ring finger oncogene; flvi-2/bmi-1; MGC12685; murine leukemia viral (bmi-1) oncogene homolog; oncogene BMI-1; PCGF4; Polycomb complex protein BMI-1; polycomb group protein Bmi1; polycomb group ring finger 4; Polycomb group RING finger protein 4; RING finger protein 51; RNF51
Gene Symbols: BMI1
Molecular weight: 36,949 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BMI1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 K81-ub TLQDIVYkLVPGLFK
0 1 K151-ac DRKVNKDkEKSKEEV
0 1 Y163 EEVNDKRYLRCPAAM
0 1 Y203-p EEEPLKDyyTLMDIA
0 1 Y204-p EEPLKDyyTLMDIAY
0 2 T244-p SHQRDGLtNAGELEs
0 9 S251-p tNAGELEsDsGsDKA
0 10 S253-p AGELEsDsGsDKANs
0 9 S255-p ELEsDsGsDKANsPA
0 10 S260-p sGsDKANsPAGGIPS
0 1 S269-p AGGIPSTsSCLPsPs
0 9 S274-p STsSCLPsPstPVQs
0 9 S276-p sSCLPsPstPVQsPH
0 12 T277-p SCLPsPstPVQsPHP
0 7 S281-p sPstPVQsPHPQFPH
0 1 S290-p HPQFPHIsSTMNGTS
0 13 S315-p FANRPRKssVNGSSA
1 49 S316-p ANRPRKssVNGSSAT
  mouse

 
K81 TLQDIVYKLVPGLFK
K149 RLDRKVNKEKPKEEV
Y161-p EEVNDKRyLRCPAAM
Y201 EEEPLKDYYTLMDIA
Y202 EEPLKDYYTLMDIAY
T242 SHQRDGLTNAGELEs
S249-p TNAGELEsDsGsDKA
S251-p AGELEsDsGsDKANS
S253-p ELEsDsGsDKANSPA
S258 sGsDKANSPAGGVPS
S267 AGGVPSTSSCLPSPS
S272 STSSCLPSPSTPVQS
S274 SSCLPSPSTPVQSPH
T275 SCLPSPSTPVQSPHP
S279 SPSTPVQSPHPQFPH
S288 HPQFPHISSTMNGTS
S313 FASRPRKSsLNGSSA
S314-p ASRPRKSsLNGSSAT
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