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ARF6 (human)

Overview ARF6 GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development. Contributes to the regulation of dendritic branching and filopodia extension. Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24. Belongs to the small GTPase superfamily. Arf family. Note: This description may include information from UniProtKB. Protein type: G protein, monomeric (Arf); Motility/polarity/chemotaxis Cellular Component: ruffle; Golgi apparatus; filopodium membrane; recycling endosome; membrane; early endosome; plasma membrane; endosome membrane; cell cortex; endosome Molecular Function: GTPase activity; protein binding; GTP binding; thioesterase binding Biological Process: apoptosis; regulation of filopodium formation; liver development; vesicle-mediated transport; regulation of Rac protein signal transduction; protein transport; positive regulation of actin filament polymerization; GTP catabolic process; small GTPase mediated signal transduction; ruffle organization and biogenesis; negative regulation of receptor-mediated endocytosis; cortical actin cytoskeleton organization and biogenesis; cell adhesion; cell motility Reference #:  P62330 (UniProtKB) Alt. Names/Synonyms: ADP-ribosylation factor 6; ARF6; DKFZp564M0264 Gene Symbols: ARF6 Molecular weight: 20,082 Da Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ARF6 1E0S - A=1-175 (human) 2A5D - A=1-175 (human) 2A5F - A=1-175 (human) 2A5G - A=1-175 (human) 2BAO - A=1-10 (human) 2BAU - A=1-10 (human) 2J5X - A/B=1-175 (human) 2W83 - A/E/B=13-175 (human) 3LVQ - E=11-175 (human) 3LVR - E=11-175 (human) 3N5C - A/B=14-175 (human) 3PCR - B=14-175 (human) 4FME - F/C=14-173 (human) 3VHX - A/C/G/E=13-175 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME  |  Phospho3D  |  DISEASE  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K12	LSKIFGNKEMRILML
0	5		K32-u	GKTTILYkLkLGQSV
0	3		K34-u	TTILYkLkLGQSVTT
0	12		K55-u	NVETVTYkNVkFNVW
0	2		K58-u	TVTYkNVkFNVWDVG
0	39		K69-u	WDVGGQDkIRPLWRH
0	1		K138	KPHEIQEKLGLTRIR
0	1		Y163-p	ATSGDGLyEGLtWLT
0	1		T167-p	DGLyEGLtWLTSNYk
0	3		K174-u	tWLTSNYkS______

	mouse
K12-a	LSKIFGNkEMRILML
K32-u	GKTTILYkLkLGQSV
K34-u	TTILYkLkLGQSVTT
K55-u	NVETVTYkNVKFNVW
K58	TVTYkNVKFNVWDVG
K69-u	WDVGGQDkIRPLWRH
K138-u	KPHEIQEkLGLTRIR
Y163	ATSGDGLYEGLTWLT
T167	DGLYEGLTWLTSNYK
K174	TWLTSNYKS______

	rat
K12	LSKIFGNKEMRILML
K32	GKTTILYKLKLGQSV
K34	TTILYKLKLGQSVTT
K55	NVETVTYKNVKFNVW
K58	TVTYKNVKFNVWDVG
K69	WDVGGQDKIRPLWRH
K138	KPHEIQEKLGLTRIR
Y163	ATSGDGLYEGLTWLT
T167	DGLYEGLTWLTSNYK
K174	TWLTSNYKS______

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