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Protein Page:
ARF6 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ARF6 GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in the regulation of dendritic spine development. Contributes to the regulation of dendritic branching and filopodia extension. Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4. Interacts with USP6 (via Rab-GAP TBC domain). Interacts with ECM29. Interacts with TBC1D24. Belongs to the small GTPase superfamily. Arf family. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxis
Cellular Component: ruffle; Golgi apparatus; filopodium membrane; membrane; endocytic vesicle; recycling endosome membrane; early endosome; plasma membrane; midbody; cell cortex; endosome; cleavage furrow
Molecular Function: GTPase activity; protein binding; GTP binding; thioesterase binding
Biological Process: myeloid cell apoptosis; regulation of filopodium formation; cell cycle; liver development; vesicle-mediated transport; regulation of Rac protein signal transduction; protein transport; positive regulation of actin filament polymerization; cell division; GTP catabolic process; small GTPase mediated signal transduction; ruffle organization and biogenesis; negative regulation of receptor-mediated endocytosis; cortical actin cytoskeleton organization and biogenesis; cell adhesion; cell motility
Reference #:  P62330 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor 6; ARF6; DKFZp564M0264
Gene Symbols: ARF6
Molecular weight: 20,082 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ARF6

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K12 LSKIFGNKEMRILML
0 5 K32-ub GKTTILYkLkLGQSV
0 3 K34-ub TTILYkLkLGQSVTT
0 12 K55-ub NVETVTYkNVkFNVW
0 2 K58-ub TVTYkNVkFNVWDVG
0 39 K69-ub WDVGGQDkIRPLWRH
0 1 K138 KPHEIQEKLGLTRIR
0 1 Y150-p RIRDRNWyVQPSCAT
0 1 Y163-p ATSGDGLyEGLtWLT
0 1 T167-p DGLyEGLtWLTSNYk
0 3 K174-ub tWLTSNYkS______
  mouse

 
K12-ac LSKIFGNkEMRILML
K32-ub GKTTILYkLkLGQSV
K34-ub TTILYkLkLGQSVTT
K55-ub NVETVTYkNVKFNVW
K58 TVTYkNVKFNVWDVG
K69-ub WDVGGQDkIRPLWRH
K138-ub KPHEIQEkLGLTRIR
Y150 RIRDRNWYVQPSCAT
Y163 ATSGDGLYEGLTWLT
T167 DGLYEGLTWLTSNYK
K174 TWLTSNYKS______
  rat

 
K12 LSKIFGNKEMRILML
K32 GKTTILYKLKLGQSV
K34 TTILYKLKLGQSVTT
K55 NVETVTYKNVKFNVW
K58 TVTYKNVKFNVWDVG
K69 WDVGGQDKIRPLWRH
K138 KPHEIQEKLGLTRIR
Y150 RIRDRNWYVQPSCAT
Y163 ATSGDGLYEGLTWLT
T167 DGLYEGLTWLTSNYK
K174 TWLTSNYKS______
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