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Protein Page:
ALPP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ALPP There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
Protein type: Motility/polarity/chemotaxis; Membrane protein, GPI anchor; Cofactor and Vitamin Metabolism - folate biosynthesis; Cell surface; EC 3.1.3.1; Phosphatase (non-protein); Membrane protein, integral
Cellular Component: cell surface; integral to membrane; plasma membrane
Molecular Function: zinc ion binding; alkaline phosphatase activity; magnesium ion binding
Biological Process: dephosphorylation
Reference #:  P05187 (UniProtKB)
Alt. Names/Synonyms: Alkaline phosphatase Regan isozyme; alkaline phosphatase, placental (Regan isozyme); Alkaline phosphatase, placental type; alkaline phosphomonoesterase; ALP; ALPP; FLJ61142; glycerophosphatase; PALP; Placental alkaline phosphatase 1; PLAP; PLAP-1; PPB1
Gene Symbols: ALPP
Molecular weight: 57,954 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ALPP

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K46-sc AEALGAAkKLQPAQT
0 11 S114-p VDKHVPDsGAtATAY
0 2 T117-p HVPDsGAtATAYLCG
0 1 S177-p TTRVQHAsPAGTYAH
0 1 K262-sc LVQEWLAkRQGARYV
  mouse

 
K42 AEALDAAKKLKPIQT
S110 TDKQIPDSAGTGTAF
T113 QIPDSAGTGTAFLCG
S173 TTSVQHASPAGTYAH
K258 LVQEWLAKHQGARYV
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