There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
Protein type: EC 18.104.22.168; Cofactor and Vitamin Metabolism - folate biosynthesis; Membrane protein, GPI anchor; Cell surface; Phosphatase (non-protein); Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: cell surface; integral to membrane; plasma membrane
Molecular Function: alkaline phosphatase activity; zinc ion binding; magnesium ion binding
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.