Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ADAMTS13 (human)

Overview
ADAMTS13 Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; EC 3.4.24.87; Calcium-binding protein; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted, signal peptide; Secreted; Protease
Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface
Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding
Biological Process: integrin-mediated signaling pathway; platelet activation; glycoprotein metabolic process; cell-matrix adhesion; peptide catabolic process; protein processing; proteolysis
Reference #:  Q76LX8 (UniProtKB)
Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; ADAM-TS 13; ADAM-TS13; ADAMTS-13; ADAMTS13; ATS13; C9orf8; DKFZp434C2322; FLJ42993; MGC118899; MGC118900; TTP; von Willebrand factor-cleaving protease; vWF-cleaving protease; vWF-CP; VWFCP
Gene Symbols: ADAMTS13
Molecular weight: 153,604 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Select Structure to View Below

ADAMTS13

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S272 CSRRQLLSLLSAGRA
0 1 S275 RQLLSLLSAGRARCV
0 2 T358-p LVPLLDGtECGVEKW
0 1 T435-p LQAEMCNtQACEKTQ
0 1 S696-p AAVRGPCsVsCGAGL
0 1 S698-p VRGPCsVsCGAGLRW
0 1 T779 AQGSLLKTLPPARCR
0 1 T1294-p GSQLAPEtFyRECDM
0 1 Y1296-p QLAPEtFyRECDMQL
0 1 S1356-p GTEGANAsyILIRDT
0 1 Y1357-p TEGANAsyILIRDTH
  ADAMTS13 iso3  
S272-p CSRRQLLsLLsANEQ
S275-p RQLLsLLsANEQCRV
T327 LVPLLDGTECGVEKW
T404 LQAEMCNTQACEKTQ
S665 AAVRGPCSVSCGAGL
S667 VRGPCSVSCGAGLRW
T748 AQGSLLKTLPPARCR
T1207 GSQLAPETFYRECDM
Y1209 QLAPETFYRECDMQL
S1269 GTEGANASYILIRDT
Y1270 TEGANASYILIRDTH
  mouse

 
H277 CSQRQLQHLLSTGQM
S280 RQLQHLLSTGQMHCF
T363 LVPLLDGTECGVEKW
T440 LQAKMCNTQACEKTQ
S701 TAKRGPCSVSCGAGL
S703 KRGPCSVSCGAGLRW
T784-p TQDGFLKtLPPARCR
T1298 WSQPAPGTFYKECDR
Y1300 QPAPGTFYKECDRQL
N1360 ASEGTNANYVSIRDI
Y1361 SEGTNANYVSIRDIH
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.