Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
ADAMTS13 (human)

Overview
ADAMTS13 Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Extracellular matrix; Secreted, signal peptide; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; EC 3.4.24.87; Calcium-binding protein
Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface
Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding
Biological Process: integrin-mediated signaling pathway; platelet activation; glycoprotein metabolic process; cell-matrix adhesion; peptide catabolic process; protein processing; proteolysis
Reference #:  Q76LX8 (UniProtKB)
Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; ADAM-TS 13; ADAM-TS13; ADAMTS-13; ADAMTS13; ATS13; C9orf8; DKFZp434C2322; FLJ42993; MGC118899; MGC118900; TTP; von Willebrand factor-cleaving protease; vWF-cleaving protease; vWF-CP; VWFCP
Gene Symbols: ADAMTS13
Molecular weight: 153,604 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Select Structure to View Below

ADAMTS13

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 T358-p LVPLLDGtECGVEKW
  ADAMTS13 iso3  
T327 LVPLLDGTECGVEKW
  mouse

 
T363 LVPLLDGTECGVEKW
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.