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Fos (human)

Overview Fos a proto-oncogenic transcription factor of the bZIP family. Dimerizes with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins function as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of FOS has also been associated with apoptotic cell death. Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; DNA binding protein; Transcription factor Cellular Component: nucleoplasm; transcription factor complex; nucleolus; nucleus Molecular Function: protein binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; response to gravity; response to cAMP; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; response to lipopolysaccharide; female pregnancy; toll-like receptor 3 signaling pathway; regulation of transcription factor activity; conditioned taste aversion; transforming growth factor beta receptor signaling pathway; DNA methylation; inflammatory response; toll-like receptor 4 signaling pathway; response to corticosterone stimulus; aging; response to drug; response to light stimulus; nervous system development; MyD88-independent toll-like receptor signaling pathway; sleep; Toll signaling pathway; cellular response to hormone stimulus; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; regulation of transcription from RNA polymerase II promoter; MyD88-dependent toll-like receptor signaling pathway; response to mechanical stimulus; response to cytokine stimulus; cellular response to extracellular stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to cold; response to progesterone stimulus Reference #:  P01100 (UniProtKB) Alt. Names/Synonyms: activator protein 1; AP-1; C-FOS; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Proto-oncogene c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog Gene Symbols: FOS Molecular weight: 40,695 Da Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states CST Pathways:  ErbB/HER Signaling  |  MAPK/Erk in Growth and Differentiation  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Fos 1A02 - F=139-193 (human) 1FOS - E=139-198, G=140-198 (human) 1S9K - D=140-192 (human) 2WT7 - A=138-200 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A02 1FOS 1S9K  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
transcription, altered: T232‑p activation: T232‑p intracellular localization: Y10‑p, Y30‑p, T232‑p molecular association, regulation: S32‑p protein stabilization: S32‑p, S308‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	0		Y10-p	FSGFNADyEASSSRC
2	0		Y30-p	AGDSLSYyHsPADSF
1	0		S32-p	DSLSYyHsPADSFSS
0	1		K113-u	YSRAGVVktMtGGRA
0	1		T114-p	SRAGVVktMtGGRAQ
0	1		T116-p	AGVVktMtGGRAQSI
4	0		T232-p	GGLPEVAtPESEEAF
2	0		K265-s	SISSMELkTEPFDDF
1	0		S308-p	ADWEPLHsGSLGMGP
4	1		T325-p	TELEPLCtPVVTCtP
3	0		T331-p	CtPVVTCtPSCTAYT
10	3		S362-p	AAAHRKGssSNEPSS
0	1		S363-p	AAHRKGssSNEPSSD
7	1		S374-p	PSSDSLSsPtLLAL_
0	1		T376-p	SDSLSsPtLLAL___

	mouse
Y10	FSGFNADYEASSSRC
Y30	AGDSLSYYHSPADSF
S32	DSLSYYHSPADSFSS
K113	YARAGMVKTVSGGRA
T114	ARAGMVKTVSGGRAQ
S116	AGMVKTVSGGRAQSI
T232-p	GGLPEAStPESEEAF
K265-s	SISNVELkAEPFDDF
S308	ADWEPLHSNSLGMGP
T325-p	TELEPLCtPVVTCTP
T331	CtPVVTCTPGCTTYT
S362-p	AAAHRKGsSSNEPSS
S363	AAHRKGsSSNEPSSD
S374-p	PSSDSLSsPTLLAL_
T376	SDSLSsPTLLAL___

	rat
Y10	FSGFNADYEASSSRC
Y30	AGDSLSYYHSPADSF
S32	DSLSYYHSPADSFSS
K113	YARAGVVKTMSGGRA
T114	ARAGVVKTMSGGRAQ
S116	AGVVKTMSGGRAQSI
T232	GGLPEATTPESEEAF
K265	NISNMELKAEPFDDF
S308	ADWEPLHSSSLGMGP
T325-p	TELEPLCtPVVTCtP
T331-p	CtPVVTCtPSCTTYT
S362-p	AAAHRKGsSSNEPSS
S363	AAHRKGsSSNEPSSD
S374-p	PSSDSLSsPTLLAL_
T376	SDSLSsPTLLAL___

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