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Protein Page:
Fos (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Fos a proto-oncogenic transcription factor of the bZIP family. Dimerizes with proteins of the JUN family, thereby forming the transcription factor complex AP-1. FOS proteins function as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of FOS has also been associated with apoptotic cell death. Expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; neuron projection; membrane; endoplasmic reticulum; nucleolus; nucleus; cytosol
Molecular Function: protein binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; response to gravity; response to cAMP; positive regulation of osteoclast differentiation; positive regulation of transcription, DNA-dependent; response to toxin; stress-activated MAPK cascade; response to lipopolysaccharide; female pregnancy; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of transcription factor activity; transforming growth factor beta receptor signaling pathway; conditioned taste aversion; DNA methylation; inflammatory response; toll-like receptor 4 signaling pathway; response to corticosterone stimulus; aging; response to drug; response to light stimulus; nervous system development; MyD88-independent toll-like receptor signaling pathway; sleep; cellular response to hormone stimulus; toll-like receptor 2 signaling pathway; regulation of transcription from RNA polymerase II promoter; MyD88-dependent toll-like receptor signaling pathway; response to mechanical stimulus; response to cytokine stimulus; cellular response to extracellular stimulus; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; response to cold; response to progesterone stimulus
Reference #:  P01100 (UniProtKB)
Alt. Names/Synonyms: activator protein 1; AP-1; C-FOS; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Proto-oncogene c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
Gene Symbols: FOS
Molecular weight: 40,695 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Fos

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: T232‑p
activity, induced: T232‑p
intracellular localization: Y10‑p, Y30‑p, T232‑p
molecular association, regulation: S32‑p
protein stabilization: S32‑p, S308‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 Y10-p FSGFNADyEASSSRC
2 0 Y30-p AGDSLSYyHsPADSF
1 0 S32-p DSLSYyHsPADSFSS
0 1 K113-ub YSRAGVVktMtGGRA
0 1 T114-p SRAGVVktMtGGRAQ
0 1 T116-p AGVVktMtGGRAQSI
0 2 S133-p RGKVEQLsPEEEEKR
5 0 T232-p GGLPEVAtPESEEAF
2 0 K265-sm SISSMELkTEPFDDF
0 1 S278-p DFLFPASsRPSGSET
1 0 S308-p ADWEPLHsGSLGMGP
5 1 T325-p TELEPLCtPVVTCtP
4 0 T331-p CtPVVTCtPSCTAYT
10 4 S362-p AAAHRKGssSNEPSS
0 1 S363-p AAHRKGssSNEPSSD
8 1 S374-p PSSDSLSsPtLLAL_
0 1 T376-p SDSLSsPtLLAL___
5348 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb
8677 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8709 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
11919 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (PE Conjugate)
  mouse

 
Y10 FSGFNADYEASSSRC
Y30 AGDSLSYYHSPADSF
S32 DSLSYYHSPADSFSS
K113 YARAGMVKTVSGGRA
T114 ARAGMVKTVSGGRAQ
S116 AGMVKTVSGGRAQSI
S133 RGKVEQLSPEEEEKR
T232-p GGLPEAStPESEEAF
K265-sm SISNVELkAEPFDDF
S278 DFLFPASSRPSGSET
S308 ADWEPLHSNSLGMGP
T325-p TELEPLCtPVVTCTP
T331 CtPVVTCTPGCTTYT
S362-p AAAHRKGsSSNEPSS
S363 AAHRKGsSSNEPSSD
S374-p PSSDSLSsPTLLAL_
T376 SDSLSsPTLLAL___
5348 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb
8677 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8709 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
11919 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (PE Conjugate)
  rat

 
Y10 FSGFNADYEASSSRC
Y30 AGDSLSYYHSPADSF
S32 DSLSYYHSPADSFSS
K113 YARAGVVKTMSGGRA
T114 ARAGVVKTMSGGRAQ
S116 AGVVKTMSGGRAQSI
S133 RGKVEQLSPEEEEKR
T232 GGLPEATTPESEEAF
K265 NISNMELKAEPFDDF
S278 DFLFPASSRPSGSET
S308 ADWEPLHSSSLGMGP
T325-p TELEPLCtPVVTCtP
T331-p CtPVVTCtPSCTTYT
S362-p AAAHRKGsSSNEPSS
S363 AAHRKGsSSNEPSSD
S374-p PSSDSLSsPTLLAL_
T376 SDSLSsPTLLAL___
5348 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb
8677 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (Alexa Fluor(R) 647 Conjugate)
8709 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (Alexa Fluor(R) 488 Conjugate)
11919 : Phospho-c-Fos (Ser32) (D82C12) XP(R) Rabbit mAb (PE Conjugate)
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