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EFNB2 (human)

Overview EFNB2 a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase Cellular Component: integral to plasma membrane; plasma membrane Molecular Function: ephrin receptor binding Biological Process: nervous system development; organ morphogenesis; anatomical structure morphogenesis; Notch signaling pathway; regulation of chemotaxis; cell migration during sprouting angiogenesis; cell-cell signaling; virus-host interaction; ephrin receptor signaling pathway; cell adhesion; cell differentiation; lymph vessel development Reference #:  P52799 (UniProtKB) Alt. Names/Synonyms: EFNB2; EPH-related receptor tyrosine kinase ligand 5; ephrin B2; Ephrin-B2; EPLG5; HTK ligand; HTK-L; HTKL; LERK-5; LERK5; ligand of eph-related kinase 5; MGC126226; MGC126227; MGC126228 Gene Symbols: EFNB2 Molecular weight: 36,923 Da Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states

Select Structure to View Below EFNB2 2HLE - B=28-165 (human) 2I85 - A=25-166 (human) 2VSK - D/B=28-165 (human) 2VSM - B=28-165 (human) 2WO2 - B=27-167 (human) 3GXU - B=27-169 (human) 1IKO - P=30-207 (mouse) 1KGY - E/F/G/H=31-168 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2HLE 2I85 2VSK 2VSM 2WO2 3GXU  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
molecular association, regulation: Y304‑p protein conformation: Y304‑p, Y311‑p, Y316‑p protein stabilization: Y311‑p, Y316‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y11-p	RRDSVWKyCWGVLMV
0	1		T69-p	CPKVDSKtVGQYEYY
0	3		S260-p	RRRHRKHsPQHTTTL
0	1		S268-p	PQHTTTLsLSTLAtP
0	3		T274-p	LsLSTLAtPKRSGNN
1	216		Y304-p	DSVFCPHyEKVsGDy
0	14		S308-p	CPHyEKVsGDyGHPV
2	115		Y311-p	yEKVsGDyGHPVyIV
2	111		Y316-p	GDyGHPVyIVQEMPP
0	151		Y330-p	PQSPANIyyKV____
0	30		Y331-p	QSPANIyyKV_____

	mouse
Y14	RRDSVWKYCWGLLMV
T72	CPKVDSKTVGQYEYY
S263-p	RRRHRKHsPQHTTTL
S271	PQHTTTLSLSTLAtP
T277-p	LSLSTLAtPKRGGNN
Y307-p	DSVFCPHyEKVsGDy
S311-p	CPHyEKVsGDyGHPV
Y314-p	yEKVsGDyGHPVyIV
Y319-p	GDyGHPVyIVQEMPP
Y333-p	PQSPANIyYKV____
Y334	QSPANIyYKV_____

	rat
Y14	RRDSVWKYCWGLLMV
T72	CPKVDSKTVGQYEYY
S263	RRRHRKHSPQHTTTL
S271	PQHTTTLSLSTLATP
T277	LSLSTLATPKRGGNN
Y307-p	DSVFCPHyEKVSGDY
S311	CPHyEKVSGDYGHPV
Y314	yEKVSGDYGHPVYIV
Y319	GDYGHPVYIVQEMPP
Y333	PQSPANIYYKV____
Y334	QSPANIYYKV_____

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