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Protein Page:
EFNB2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EFNB2 a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons Note: This description may include information from UniProtKB.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; ephrin receptor binding
Biological Process: axon guidance; anatomical structure morphogenesis; organ morphogenesis; regulation of chemotaxis; viral reproduction; cell migration during sprouting angiogenesis; cell-cell signaling; ephrin receptor signaling pathway; lymph vessel development; cell adhesion
Reference #:  P52799 (UniProtKB)
Alt. Names/Synonyms: EFNB2; EPH-related receptor tyrosine kinase ligand 5; ephrin B2; Ephrin-B2; EPLG5; HTK ligand; HTK-L; HTKL; LERK-5; LERK5; ligand of eph-related kinase 5; MGC126226; MGC126227; MGC126228
Gene Symbols: EFNB2
Molecular weight: 36,923 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
Select Structure to View Below

EFNB2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y304‑p
protein conformation: Y304‑p, Y311‑p, Y316‑p
protein stabilization: Y311‑p, Y316‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y11-p RRDSVWKyCWGVLMV
0 1 T69-p CPKVDSKtVGQYEYY
0 1 T180-ga STRNKDPtRRPELEA
0 1 T189-ga RPELEAGtNGRSSTT
0 4 S260-p RRRHRKHsPQHtTTL
0 1 T264-p RKHsPQHtTTLsLsT
0 2 S268-p PQHtTTLsLsTLAtP
0 1 S270-p HtTTLsLsTLAtPKR
0 5 T274-p LsLsTLAtPKRSGNN
0 1 R277 sTLAtPKRSGNNNGS
1 215 Y304-p DSVFCPHyEKVsGDy
0 15 S308-p CPHyEKVsGDyGHPV
2 116 Y311-p yEKVsGDyGHPVyIV
3 112 Y316-p GDyGHPVyIVQEMPP
0 153 Y330-p PQSPANIyyKV____
0 30 Y331-p QSPANIyyKV_____
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
  mouse

 
Y14 RRDSVWKYCWGLLMV
T72 CPKVDSKTVGQYEYY
T183 SARNHGPTRRPELEA
T192 RPELEAGTNGRSSTT
S263-p RRRHRKHsPQHTTTL
T267 RKHsPQHTTTLSLST
S271 PQHTTTLSLSTLAtP
S273 HTTTLSLSTLAtPKr
T277-p LSLSTLAtPKrGGNN
R280-m1 STLAtPKrGGNNNGS
Y307-p DSVFCPHyEKVsGDy
S311-p CPHyEKVsGDyGHPV
Y314-p yEKVsGDyGHPVyIV
Y319-p GDyGHPVyIVQEMPP
Y333-p PQSPANIyYKV____
Y334 QSPANIyYKV_____
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
  rat

 
Y14 RRDSVWKYCWGLLMV
T72 CPKVDSKTVGQYEYY
T183 STRNNDPTRRPELEA
T192 RPELEAGTNGRSSTT
S263 RRRHRKHSPQHTTTL
T267 RKHSPQHTTTLSLST
S271 PQHTTTLSLSTLATP
S273 HTTTLSLSTLATPKR
T277 LSLSTLATPKRGGNN
R280 STLATPKRGGNNNGS
Y307-p DSVFCPHyEKVSGDY
S311 CPHyEKVSGDYGHPV
Y314 yEKVSGDYGHPVYIV
Y319 GDYGHPVYIVQEMPP
Y333 PQSPANIYYKV____
Y334 QSPANIYYKV_____
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