a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphA3 and EphB4. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B2 is implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. May play a role in constraining the orientation of longitudinally projecting axons Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 13q33
Cellular Component: focal adhesion; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; ephrin receptor binding
Biological Process: axon guidance; organ morphogenesis; anatomical structure morphogenesis; regulation of chemotaxis; viral reproduction; cell-cell signaling; cell migration during sprouting angiogenesis; ephrin receptor signaling pathway; lymph vessel development; cell adhesion
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.