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USP54 (human)

Overview USP54 Has no peptidase activity. Belongs to the peptidase C19 family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Ubiquitin conjugating system; Ubiquitin-specific protease Molecular Function: ubiquitin thiolesterase activity; protein binding Biological Process: ubiquitin-dependent protein catabolic process Reference #:  Q6ZTM0 (UniProtKB) Alt. Names/Synonyms: bA137L10.3; bA137L10.4; C10orf29; FLJ37318; Inactive ubiquitin carboxyl-terminal hydrolase 54; Inactive ubiquitin-specific peptidase 54; ubiquitin specific peptidase 54; ubiquitin specific protease 54; ubiquitin specific proteinase 54; UBP54; USP54 Gene Symbols: USP54 Molecular weight: 187,388 Da Basal Isoelectric point: 6.89  Predict pI for various phosphorylation states

Select Structure to View Below USP54

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		Y7-p	_MSWKRNyFSGGrGS
0	1		R12-m1	RNyFSGGrGSVQGMF
0	1		S23	QGMFAPRSSTSIAPS
0	1		K105-u	TLRSALAkTFQDEQR
0	1		S227	GDLRNCPSNCGERIR
0	1		T374-p	EFQSYSRtCyDsEDs
0	1		Y376-p	QSYSRtCyDsEDsGR
0	7		S378-p	YSRtCyDsEDsGREP
0	6		S381-p	tCyDsEDsGREPSIS
0	10		T442-p	SRDTGHLtDSECNQK
0	1		T451-p	SECNQKHtsKKGSLI
0	1		S452-p	ECNQKHtsKKGSLIE
0	6		S481-p	PQASGYHsEGETLKE
0	2		T485	GYHsEGETLKEKQAP
0	1		R546	QPDKKPPRTLPLHSR
0	1		S603-p	HCGYTQLsPFSEDSA
0	1		S632-p	DIKFGGPsPQyKRWG
0	72		Y635-p	FGGPsPQyKRWGPAR
0	1		S660-p	RLIQRMEsGyESSER
0	1		Y662-p	IQRMEsGyESSERNS
0	3		S671-p	SSERNSSsPVSLDAA
0	1		S674	RNSSsPVSLDAALPE
0	1		S682-p	LDAALPEsSNVYRDP
0	1		S690-p	SNVYRDPsAKRSAGL
0	1		K769-u	EKELEAAkGFNPHPS
0	9		Y1069-p	AQPSLPLyRTCHPIM
0	2		Y1118-p	DRGSEETyRPEFPST
0	3		S1189	PWAKQQSSLEGGDRP
0	5		Y1233-p	RLAEPDIyQEkLSQV
0	1		K1236-u	EPDIyQEkLSQVRDV
0	1		K1246-u	QVRDVRSkDLGSSTD
0	1		S1362-p	GMGRRLHsAHDPGLS
0	1		S1398	ATPCRGLSRECGEDE
0	1		S1439	VSSHSFDSSNVRKPL
0	1		S1440	SSHSFDSSNVRKPLE
0	1		K1521-u	GETSQGAkYTGRTLN
0	48		Y1529-p	YTGRTLNyQsLPHRS
0	7		S1531-p	GRTLNyQsLPHRSRT
0	1		Y1568-p	GCNPQLTyTATLPER
0	2		S1645	PDDDWRQSSYASHSG
0	2		S1646	DDDWRQSSYASHSGH
0	2		Y1647	DDWRQSSYASHSGHR
0	2		S1649	WRQSSYASHSGHRRT

	USP54 iso10
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
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-	gap
-	gap
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-	gap
-	gap
Y157	AQPSLPLYRTCHPIM
Y206	DRGSEETYRPEFPST
S277	PWAKQQSSLEGGDRP
Y321-p	RLAEPDIyQEKLSQV
K324	EPDIyQEKLSQVRDV
K334	QVRDVRSKDLGSSTD
S450	GMGRRLHSAHDPGLS
S481-p	ATPCRGLsRECGEDE
S522	VSSHSFDSSNVRKPL
S523	SSHSFDSSNVRKPLE
K604	GETSQGAKYTGRTLN
Y612	YTGRTLNYQSLPHRS
S614	GRTLNYQSLPHRSRT
Y651	GCNPQLTYTATLPER
S728	PDDDWRQSSYASHSG
S729	DDDWRQSSYASHSGH
Y730	DDWRQSSYASHSGHR
S732	WRQSSYASHSGHRRT

	mouse
Y7	_MSWKRNYFSGSRGS
R12	RNYFSGSRGSVQGMF
S23-p	QGMFAPRsSMSIAPS
K105	TLRSALAKTFQDEQR
S227-p	GDLRNCPsNCGERIR
T374	QFLPYTKTCYDsEDs
Y376	LPYTKTCYDsEDsGH
S378-p	YTKTCYDsEDsGHLt
S381-p	TCYDsEDsGHLtDSE
T385-p	sEDsGHLtDSECNQK
T394	SECNQKHTSKKGSLV
S395	ECNQKHTSKKGSLVE
S424-p	PQASGYHsEGEtLKE
T428-p	GYHsEGEtLKEKQAP
R488-m1	QLDKIPPrNFPLQAR
R545	HCGYTQLRTFPEDAA
R574	DIKDGGSRSQHKLWG
H577	DGGSRSQHKLWGTAR
S602	RLIQRMESGYESSER
Y604	IQRMESGYESSERNS
S613-p	SSERNSSsPVsLDAA
S616-p	RNSSsPVsLDAAPPD
S624	LDAAPPDSVNVYRDQ
S632	VNVYRDQSTKRPVGF
K711	EKELEAAKGFNPHPS
Y1018	AQPSIPPYSSCHPIT
Y1067	VRSSEEPYRLEFPST
S1138-p	RWVKQPRsPDGRERP
Y1182	RLAEPDMYQGKLPQV
K1185	EPDMYQGKLPQVTDI
K1195	QVTDIRSKELGSSVN
S1312-p	GMGRRLHsAPGLDLS
-	gap
S1342-p	TVPVSQDssNVRKKT
S1343-p	VPVSQDssNVRKKTL
K1425	DETPQGVKYTGRTLN
Y1433	YTGRTLNYRSLPHRS
S1435	GRTLNYRSLPHRSRT
Y1472	ACKPQLTYTATLPER
S1549-p	PDDDWRQssyPsQDR
S1550-p	DDDWRQssyPsQDRH
Y1551-p	DDWRQssyPsQDRHR
S1553-p	WRQssyPsQDRHRSP

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