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Protein Page:
UGT1A8 (human)

Overview
UGT1A8 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; Transferase; Carbohydrate Metabolism - ascorbate and aldarate; EC 2.4.1.17; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - pentose and glucuronate interconversions; Xenobiotic Metabolism - metabolism by cytochrome P450; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - starch and sucrose
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; integral to membrane
Molecular Function: enzyme inhibitor activity; protein homodimerization activity; enzyme binding; retinoic acid binding; glucuronosyltransferase activity; protein heterodimerization activity; drug binding; fatty acid binding; steroid binding
Biological Process: steroid metabolic process; negative regulation of steroid metabolic process; coumarin metabolic process; negative regulation of catalytic activity; flavone metabolic process; retinoic acid metabolic process; negative regulation of cellular metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process; fatty acid metabolic process
Reference #:  Q9HAW9 (UniProtKB)
Alt. Names/Synonyms: GNT1; UD18; UDP glucuronosyltransferase 1 family, polypeptide A8; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1 family polypeptide A8s; UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A8; UDPGT; UDPGT 1-8; UGT-1H; UGT1; UGT1*8; UGT1-08; UGT1.8; UGT1A8; UGT1A8S; UGT1H
Gene Symbols: UGT1A8
Molecular weight: 59,742 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
Select Structure to View Below

UGT1A8

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S78 NCTVKTYSTSYTLED
0 1 S80 TVKTYSTSYTLEDLD
  rat

 
S78-p NFTVKTYsVsYTLED
S80-p TVKTYsVsYTLEDLN
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