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Protein Page:
UGT1A8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UGT1A8 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transferase; Carbohydrate Metabolism - pentose and glucuronate interconversions; Membrane protein, integral; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - ascorbate and aldarate; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 2.4.1.17
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane
Molecular Function: enzyme inhibitor activity; enzyme binding; protein homodimerization activity; retinoic acid binding; glucuronosyltransferase activity; protein heterodimerization activity; drug binding; fatty acid binding; steroid binding
Biological Process: steroid metabolic process; negative regulation of steroid metabolic process; coumarin metabolic process; negative regulation of catalytic activity; flavone metabolic process; retinoic acid metabolic process; negative regulation of cellular metabolic process; negative regulation of fatty acid metabolic process; drug metabolic process; fatty acid metabolic process
Reference #:  Q9HAW9 (UniProtKB)
Alt. Names/Synonyms: GNT1; UD18; UDP glucuronosyltransferase 1 family, polypeptide A8; UDP glycosyltransferase 1 family, polypeptide A8; UDP-glucuronosyltransferase 1 family polypeptide A8s; UDP-glucuronosyltransferase 1-8; UDP-glucuronosyltransferase 1-H; UDP-glucuronosyltransferase 1A8; UDPGT; UDPGT 1-8; UGT-1H; UGT1; UGT1*8; UGT1-08; UGT1.8; UGT1A8; UGT1A8S; UGT1H
Gene Symbols: UGT1A8
Molecular weight: 59,742 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
Select Structure to View Below

UGT1A8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S78 NCTVKTYSTSYTLED
0 1 S80 TVKTYSTSYTLEDLD
0 1 Y334-p PQTVLWRyTGTRPSN
0 1 K434-ac VINDKSYkENIMRLS
  rat

 
S78-p NFTVKTYsVsYTLED
S80-p TVKTYsVsYTLEDLN
Y334 PQTVLWRYTGTRPSN
K434 VINNKSYKENIMRLS
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