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Protein Page:
CCL13 (human)

Overview
CCL13 Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Chemokine
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: extracellular space
Molecular Function: chemokine activity; receptor binding
Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; immune response; cytoskeleton organization and biogenesis; signal transduction; chemotaxis; inflammatory response
Reference #:  Q99616 (UniProtKB)
Alt. Names/Synonyms: C-C motif chemokine 13; C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain; CCL13; chemokine (C-C motif) ligand 13; CK-beta-10; CKb10; MCP-4; MCP4; MGC17134; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; NCC-1; NCC1; new CC chemokine 1; SCYA13; SCYL1; small inducible cytokine subfamily A (Cys-Cys), member 13; Small-inducible cytokine A13
Gene Symbols: CCL13
Molecular weight: 10,986 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
Select Structure to View Below

CCL13

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y51 sLQRLKSYVITTSRC
  mouse

 
Y51-p PMSRLESyKRITSSR
  rat

 
Y51 PMSRLENYKRITSSR
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