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CCL13
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Chemokine |
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Cellular Component: extracellular space
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Molecular Function: chemokine activity; receptor binding
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Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; cytoskeleton organization and biogenesis; immune response; inflammatory response; signal transduction; chemotaxis
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Reference #:
Q99616 (UniProtKB)
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| Alt. Names/Synonyms: C-C motif chemokine 13; C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain; CCL13; chemokine (C-C motif) ligand 13; CK-beta-10; CKb10; MCP-4; MCP4; MGC17134; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; NCC-1; NCC1; new CC chemokine 1; SCYA13; SCYL1; small inducible cytokine subfamily A (Cys-Cys), member 13; Small-inducible cytokine A13 |
| Gene Symbols: CCL13 |
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Molecular weight: 10,986 Da
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Basal Isoelectric point: 9.94
Predict pI for various phosphorylation states
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