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Protein Page:
HER2 (rat)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HER2 a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; EGFR family
Cellular Component: microvillus; lateral loop; basolateral plasma membrane; integral to membrane; lipid raft; postsynaptic membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; plasma membrane; basal plasma membrane; endosome membrane; cytoplasmic vesicle; nucleus; receptor complex
Molecular Function: protein C-terminus binding; identical protein binding; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; Hsp90 protein binding; protein phosphatase binding; protein binding; transmembrane receptor activity; DNA binding; protein heterodimerization activity; growth factor binding; ubiquitin protein ligase binding; protein-tyrosine kinase activity; glycoprotein binding; ATP binding
Biological Process: myelination; tongue development; mammary gland involution; phosphoinositide 3-kinase cascade; positive regulation of cell adhesion; central nervous system development; peptidyl-tyrosine phosphorylation; wound healing; positive regulation of translation; protein amino acid autophosphorylation; heart development; motor axon guidance; signal transduction; positive regulation of transcription from RNA polymerase I promoter; positive regulation of MAP kinase activity; sympathetic nervous system development; glial cell differentiation; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; regulation of cell differentiation; positive regulation of cell proliferation; response to axon injury; neuromuscular junction development; negative regulation of immature T cell proliferation in the thymus; response to drug; nervous system development; regulation of microtubule-based process; skeletal muscle development; transcription, DNA-dependent; liver development; positive regulation of cell growth; peripheral nervous system development; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of transcription from RNA polymerase III promoter; positive regulation of Ras protein signal transduction; positive regulation of protein amino acid phosphorylation; response to progesterone stimulus; estrus; positive regulation of Rho GTPase activity; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Reference #:  P06494 (UniProtKB)
Alt. Names/Synonyms: Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); C-erbB-2; Epidermal growth factor receptor-related protein; Erbb2; Neu; NEU proto-oncogene; p185erbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Gene Symbols: Erbb2
Molecular weight: 138,832 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HER2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
apoptosis, altered: Y1223‑p, Y1224‑p
cell growth, altered: Y879‑p, Y1250‑p
molecular association, regulation: Y879‑p, Y1114‑p, Y1141‑p, Y1223‑p, Y1224‑p, Y1250‑p
phosphorylation: Y879‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 1 K151 RSLTEILKGGVLIRG
0 1 K176 LWKDVFRKNNQLAPV
0 1 V183 KNNQLAPVDIDTNRS
5 0 T688-p RQKIRKYtMRRLLQE
0 29 T703 TELVEPLTPSGAMPN
0 1 S705 LVEPLTPSGAMPNQA
0 2 K726 ETELRKVKVLGSGAF
0 5 T735 LGSGAFGTVYKGIWI
0 130 Y737 SGAFGTVYKGIWIPD
0 2 K738 GAFGTVYKGIWIPDG
0 2 K749 IPDGENVKIPVAIKV
0 1 K755 VKIPVAIKVLRENTS
0 3 Y774 KEILDEAYVMAGVGS
0 8 T877 RLLDIDETEyHADGG
18 98 Y879-p LDIDETEyHADGGKV
0 1 K889 DGGKVPIKWMALESI
0 3 S1000 NEDLGPSSPMDSTFY
0 2 S1004 GPSSPMDSTFYRSLL
0 66 Y1007 SPMDSTFYRSLLEDD
6 25 Y1025-p DLVDAEEyLVPQQGF
0 2 S1051 TAHRRHRSSSTRSGG
0 4 S1052 AHRRHRSSSTRSGGG
0 5 S1053 HRRHRSSSTRSGGGE
0 11 S1056 HRSSSTRSGGGELTL
0 2 S1085 APSEGAGSDVFDGDL
0 2 S1109 SLSPHDLSPLQRySE
6 3 Y1114-p DLSPLQRySEDPTLP
1 0 S1115 LSPLQRySEDPTLPL
0 13 Y1129 LPPETDGYVAPLACS
0 2 A1134 DGYVAPLACSPQPEy
0 5 S1136 YVAPLACSPQPEyVN
10 44 Y1141-p ACSPQPEyVNQSEVQ
0 43 L1153 EVQPQPPLTPEGPLP
0 2 T1168 PVRPAGATLERPKTL
1 1 T1174 ATLERPKTLsPGKNG
1 2 S1176-p LERPKTLsPGKNGVV
7 5 Y1198-p GAVENPEyLVPREGT
0 3 S1216 PHPSPAFSPAFDNLy
20 11 Y1223-p SPAFDNLyyWDQNSS
23 8 Y1224-p PAFDNLyyWDQNSSE
0 5 T1242 PPSNFEGTPTAENPE
42 180 Y1250-p PTAENPEyLGLDVPV
2241 : Phospho-HER2/ErbB2 (Tyr877) Antibody
2247 : Phospho-HER2/ErbB2 (Tyr1248) Antibody
  human

► Hide Isoforms
 
K150-u RSLTEILkGGVLIQR
K175-u LWKDIFHkNNQLALt
T182-p kNNQLALtLIDTNRS
T686-p QQKIRKYtMRRLLQE
T701-p TELVEPLtPsGAMPN
S703-p LVEPLtPsGAMPNQA
K724-u ETELRKVkVLGSGAF
T733-p LGSGAFGtVykGIWI
Y735-p SGAFGtVykGIWIPD
K736-u GAFGtVykGIWIPDG
K747-u IPDGENVkIPVAIkV
K753-u VkIPVAIkVLRENTS
Y772-p KEILDEAyVMAGVGS
T875-p RLLDIDEtEyHADGG
Y877-p LDIDEtEyHADGGKV
K887-u DGGKVPIkWMALESI
S998-p NEDLGPAsPLDsTFy
S1002-p GPAsPLDsTFyRSLL
Y1005-p sPLDsTFyRSLLEDD
Y1023-p DLVDAEEyLVPQQGF
S1049-p MVHHRHRsssTRsGG
S1050-p VHHRHRsssTRsGGG
S1051-p HHRHRsssTRsGGGD
S1054-p HRsssTRsGGGDLTL
S1083-p APSEGAGsDVFDGDL
S1107-p SLPTHDPsPLQRySE
Y1112-p DPsPLQRySEDPTVP
S1113 PsPLQRySEDPTVPL
Y1127-p LPSETDGyVAPLtCs
T1132-p DGyVAPLtCsPQPEy
S1134-p yVAPLtCsPQPEyVN
Y1139-p tCsPQPEyVNQPDVR
S1151-p DVRPQPPsPREGPLP
T1166-p AARPAGAtLERPKtL
T1172-p AtLERPKtLsPGKNG
S1174-p LERPKtLsPGKNGVV
Y1196-p GAVENPEyLTPQGGA
S1214-p PHPPPAFsPAFDNLy
Y1221-p sPAFDNLyyWDQDPP
Y1222-p PAFDNLyyWDQDPPE
T1240-p PPSTFKGtPTAENPE
Y1248-p PTAENPEyLGLDVPV
2241 : Phospho-HER2/ErbB2 (Tyr877) Antibody
6942 : Phospho-HER2/ErbB2 (Tyr1196) (D66B7) Rabbit mAb
2243 : Phospho-HER2/ErbB2 (Tyr1221/1222) (6B12) Rabbit mAb
2249 : Phospho-HER2/ErbB2 (Tyr1221/1222) Antibody
2243 : Phospho-HER2/ErbB2 (Tyr1221/1222) (6B12) Rabbit mAb
2249 : Phospho-HER2/ErbB2 (Tyr1221/1222) Antibody
2244 : Phospho-HER2/ErbB2 (Tyr1248)/EGFR (Tyr1173) Antibody
2247 : Phospho-HER2/ErbB2 (Tyr1248) Antibody
  HER2 iso2  
- gap
- gap
- gap
T76 QQKIRKYTMRRLLQE
T91 TELVEPLTPSGAMPN
S93 LVEPLTPSGAMPNQA
K114 ETELRKVKVLGSGAF
T123 LGSGAFGTVYKGIWI
Y125 SGAFGTVYKGIWIPD
K126 GAFGTVYKGIWIPDG
K137 IPDGENVKIPVAIKV
K143 VKIPVAIKVLRENTS
Y162 KEILDEAYVMAGVGS
T265 RLLDIDETEYHADGG
Y267 LDIDETEYHADGGKV
K277 DGGKVPIKWMALESI
S388 NEDLGPASPLDSTFY
S392 GPASPLDSTFYRSLL
Y395 SPLDSTFYRSLLEDD
Y413 DLVDAEEYLVPQQGF
S439 MVHHRHRSSSTRSGG
S440 VHHRHRSSSTRSGGG
S441 HHRHRSSSTRSGGGD
S444 HRSSSTRSGGGDLTL
S473 APSEGAGSDVFDGDL
S497 SLPTHDPSPLQRYSE
Y502 DPSPLQRYSEDPTVP
S503 PSPLQRYSEDPTVPL
Y517 LPSETDGYVAPLTCS
T522 DGYVAPLTCSPQPEY
S524 YVAPLTCSPQPEYVN
Y529 TCSPQPEYVNQPDVR
S541 DVRPQPPSPREGPLP
T556 AARPAGATLERPKTL
T562 ATLERPKTLSPGKNG
S564 LERPKTLSPGKNGVV
Y586 GAVENPEYLTPQGGA
S604 PHPPPAFSPAFDNLY
Y611 SPAFDNLYYWDQDPP
Y612 PAFDNLYYWDQDPPE
T630 PPSTFKGTPTAENPE
Y638 PTAENPEYLGLDVPV
  mouse

 
K151 RSLTEILKGGVLIRG
K176 LWKDVLRKNNQLAPV
V183 KNNQLAPVDMDTNRS
T687-p RQKIRKYtMRRLLQE
T702-p TELVEPLtPsGAVPN
S704-p LVEPLtPsGAVPNQA
K725-u ETELRKLkVLGSGAF
T734 LGSGAFGTVyKGIWI
Y736-p SGAFGTVyKGIWIPD
K737 GAFGTVyKGIWIPDG
K748-u IPDGENVkIPVAIKV
K754 VkIPVAIKVLRENTS
Y773 KEILDEAYVMAGVGS
T876 RLLDIDETEyHADGG
Y878-p LDIDETEyHADGGKV
K888 DGGKVPIKWMALESI
S999 NEDLGPSSPMDSTFY
S1003 GPSSPMDSTFYRSLL
Y1006 SPMDSTFYRSLLEDD
Y1024 ELVDAEEYLVPQQGF
S1050 TAHRRHRSSSARSGG
S1051 AHRRHRSSSARSGGG
S1052 HRRHRSSSARSGGGE
S1055 HRSSSARSGGGELTL
S1084-p APSEGAGsDVFDGDL
S1108 SLSPHDLSPLQRysE
Y1113-p DLSPLQRysEDPTLP
S1114-p LSPLQRysEDPTLPL
Y1128 LPPETDGYVAPLACS
A1133 DGYVAPLACSPQPEY
S1135 YVAPLACSPQPEYVN
Y1140 ACSPQPEYVNQPEVR
L1152 EVRPQSPLTPEGPPP
T1167 PIRPAGATLERPKtL
T1173-p ATLERPKtLsPGKNG
S1175-p LERPKtLsPGKNGVV
Y1197-p GAVENPEyLAPRAGT
S1215 PHPSPAFSPAFDNLy
Y1222-p SPAFDNLyyWDQNSS
Y1223-p PAFDNLyyWDQNSSE
T1241 PPSTFEGTPTAENPE
Y1249-p PTAENPEyLGLDVPV
2241 : Phospho-HER2/ErbB2 (Tyr877) Antibody
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