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ZFYVE26 (human)

Overview ZFYVE26 Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Unknown function Cellular Component: centrosome; midbody Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding Biological Process: cell death; cytokinesis; cell cycle; double-strand break repair via homologous recombination Reference #:  Q68DK2 (UniProtKB) Alt. Names/Synonyms: DKFZp686F19106; DKFZp781H1112; FYVE-CENT; KIAA0321; Spastizin; SPG15; ZFY26; ZFYVE26; Zinc finger FYVE domain-containing protein 26; zinc finger, FYVE domain containing 26 Gene Symbols: ZFYVE26 Molecular weight: 284,576 Da Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ZFYVE26

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 270700 612012  |  InnateDB  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		G181	LLLEEDDGTGLCHWP
0	1		W187	DGTGLCHWPLQNALV
0	1		K295-a	PRATASGkVsPDHLD
0	1		K295-u	PRATASGkVsPDHLD
0	2		S297-p	ATASGkVsPDHLDPE
0	1		S423-p	LEWCIQQssNPIPKR
0	1		S424-p	EWCIQQssNPIPKRD
0	1		K468	DVLKLLQKVPAKDPQ
0	1		Y555	AANLFSTYLARCQQY
0	2		Y599	EPHLPEDYAEDDDIE
0	2		S615	KSPSGLRSPSESPQH
0	1		S617	PSGLRSPSESPQHIA
0	2		S619	GLRSPSESPQHIAHP
0	1		R662	DSYPGPHRHSFLDLK
0	1		K709	RSPPEKPKQESQSCS
0	1		K741	SEAQWRHKVVtSNHR
0	2		T744-p	QWRHKVVtSNHRSEE
0	9		S765-p	QPATRHPsLRRGRRT
0	2		Y873-p	ELMFMERyQEVIQEL
0	1		K886-u	ELAQVEHkIENQNSD
0	1		S896-p	NQNSDAGsSTIRRTG
0	1		Y923-p	AAAGMVFysISDVtD
0	1		S924-p	AAGMVFysISDVtDK
0	1		T929-p	FysISDVtDKLLNTS
0	2		K1045-u	LMSASQTkSESVEEk
0	1		K1052-u	kSESVEEkGGGPPRC
0	1		R1104	ALELPEPRTPPLSSL
0	1		K1136	IQTQLLQKNLGKQTP
0	1		K1331	SPRLKVSKPSLSWKE
0	1		K1469-u	WQYLFPVkDASLRSR
0	1		Y1521-p	KLAELQVyQKILGLQ
0	1		K1596	LERRDHDKALQLLRR
0	1		K1727	LLSRYAEKALDFPYP
0	1		Y1733	EKALDFPYPQREKRS
0	1		S1740	YPQREKRSDsVIHLQ
0	1		S1742-p	QREKRSDsVIHLQEI
0	2		S1764	ETLPRSPSAEFSPAA
0	2		S1780-p	PGISSIHsPsLRERS
0	2		S1782-p	ISSIHsPsLRERSFP
0	1		K1963-u	EHCCRLSkGLTNPEV
0	1		K2416-a	AARQLVEkEKYSEIQ
0	1		K2452	LNCLEAFKRIPPQEL
0	1		K2452	LNCLEAFKRIPPQEL
0	1		Y2476-p	DDNKVRAyLICCKLR

	mouse
S175-p	LLLEDHHsASLCPsP
S181-p	HsASLCPsPLQKSLL
K289	PKATLSGKDHPDPER
K289	PKATLSGKDHPDPER
-	gap
S414	LEWCVQQSSNLIPKR
S415	EWCVQQSSNLIPKRE
K459-u	EVLKLLQkEPTKDLQ
Y545-p	ASHLFPTyLARCRQY
Y589-p	EPHLPEDyAEDEDIE
S605-p	KGPLGLRsPsEsPQH
S607-p	PLGLRsPsEsPQHIA
S609-p	GLRsPsEsPQHIAAT
K651-u	DSSPGPHkHSFLDLK
K698-u	HRTPEETkLPEDQSC
K731-u	SEAQWRYkVVTSNQG
T734	QWRYkVVTSNQGSEE
S756	PIATRHSSLRRGRRT
Y864	ELMFVERYQEVIQEL
K877	ELARVEHKIENQNSD
N887	NQNSDGGNNTIRRTG
Y914	AAAGMVFYSISDVTE
S915	AAGMVFYSISDVTEK
T920	FYSISDVTEKLLSPS
K1036-u	LMQTGLAkSETLEER
R1043	kSETLEERGGGAPRS
K1095-u	ALALPESkSTPLSCL
K1127-u	IQSQLLQkTLGRQTP
K1321-u	SRGTKVSkPGLSWKE
K1459	WQYLFPVKDASLRSQ
Y1511	KLMELRVYQKILGLQ
K1586-u	LERSEHDkALQLLQR
K1717-u	LLSRYAGkALDLPyP
Y1723-p	GkALDLPyPLREKRs
S1730-p	yPLREKRsDsMIHLQ
S1732-p	LREKRsDsMIHLQEP
S1754-p	ETLSRSSsAEFSAAA
S1770-p	PGSALVRsPsPKERA
S1772-p	SALVRsPsPKERAFP
R1953	EHCCRLSRGLTNPEV
R2406	AARQLVEREKYGEIR
K2442-a	LNCLEAFkRIPPQEL
K2442-u	LNCLEAFkRIPPQEL
Y2466	DDNKVRAYLTCCKLR

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