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Protein Page:
ZFYVE26 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZFYVE26 Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: centrosome; lysosomal membrane; midbody
Molecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate binding
Biological Process: cell death; cytokinesis; double-strand break repair via homologous recombination
Reference #:  Q68DK2 (UniProtKB)
Alt. Names/Synonyms: DKFZp686F19106; DKFZp781H1112; FYVE-CENT; KIAA0321; Spastizin; SPG15; ZFY26; ZFYVE26; Zinc finger FYVE domain-containing protein 26; zinc finger, FYVE domain containing 26
Gene Symbols: ZFYVE26
Molecular weight: 284,576 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ZFYVE26

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 G181 LLLEEDDGTGLCHWP
0 1 W187 DGTGLCHWPLQNALV
0 1 K295-ac PRATASGkVsPDHLD
0 1 K295-ub PRATASGkVsPDHLD
0 6 S297-p ATASGkVsPDHLDPE
0 1 S423-p LEWCIQQssNPIPKR
0 1 S424-p EWCIQQssNPIPKRD
0 1 K468 DVLKLLQKVPAKDPQ
0 1 Y555 AANLFSTYLARCQQY
0 2 Y599 EPHLPEDYAEDDDIE
0 1 S609-p DDDIEGKsPSGLRsP
0 5 S615-p KsPSGLRsPSEsPQH
0 2 S617 PSGLRsPSEsPQHIA
0 5 S619-p GLRsPSEsPQHIAHP
0 1 S634-p ERKSERGsLGVPKTL
0 1 R662 DSYPGPHRHSFLDLK
0 1 S703-p LDEISSRsPPEKPKQ
0 1 K709 RsPPEKPKQESQSCS
0 1 K741 SEAQWRHKVVtSNHR
0 2 T744-p QWRHKVVtSNHRSEE
0 10 S765-p QPATRHPsLRRGRRT
0 1 S800-p SELSTSTsEGSLSAM
0 2 Y873-p ELMFMERyQEVIQEL
0 1 K886-ub ELAQVEHkIENQNSD
0 1 S896-p NQNSDAGsSTIRRTG
0 2 Y923-p AAAGMVFysISDVtD
0 1 S924-p AAGMVFysISDVtDK
0 1 T929-p FysISDVtDKLLNTS
0 1 S1001-p TAERRLNssLERRGR
0 1 S1002-p AERRLNssLERRGRR
0 2 K1045-ub LMSASQTkSESVEEk
0 1 K1052-ub kSESVEEkGGGPPRC
0 1 R1104 ALELPEPRTPPLSSL
0 1 K1136 IQTQLLQKNLGKQTP
0 1 S1271-p CLDDLPLsTPSSPRT
0 1 S1290-p TLERKPYssPRDSSL
0 1 S1291-p LERKPYssPRDSSLP
0 1 K1331 SPRLKVSKPSLSWKE
0 1 K1469-ub WQYLFPVkDASLRSR
0 1 Y1521-p KLAELQVyQKILGLQ
0 1 K1596 LERRDHDKALQLLRR
0 1 K1727 LLSRYAEKALDFPYP
0 1 Y1733 EKALDFPYPQREKRS
0 1 S1740 YPQREKRSDsVIHLQ
0 1 S1742-p QREKRSDsVIHLQEI
0 10 S1764-p ETLPRSPsAEFsPAA
0 1 S1768-p RSPsAEFsPAAPPGI
0 2 S1780-p PGISSIHsPsLRERS
0 2 S1782-p ISSIHsPsLRERSFP
0 1 T1802-p QEFVPPAtPPARHQW
0 1 K1963-ub EHCCRLSkGLTNPEV
0 1 K2416-ac AARQLVEkEKYSEIQ
0 1 K2452 LNCLEAFKRIPPQEL
0 1 K2452 LNCLEAFKRIPPQEL
0 1 Y2476-p DDNKVRAyLICCKLR
  mouse

 
S175-p LLLEDHHsASLCPsP
S181-p HsASLCPsPLQKSLL
K289 PKATLSGKDHPDPER
K289 PKATLSGKDHPDPER
- gap
S414 LEWCVQQSSNLIPKR
S415 EWCVQQSSNLIPKRE
K459-ub EVLKLLQkEPTKDLQ
Y545-p ASHLFPTyLARCRQY
Y589-p EPHLPEDyAEDEDIE
G599 DEDIEGKGPLGLRsP
S605-p KGPLGLRsPsEsPQH
S607-p PLGLRsPsEsPQHIA
S609-p GLRsPsEsPQHIAAT
S624 ERRSERASMGPRNPA
K651-ub DSSPGPHkHSFLDLK
R692 LTEISSHRTPEETkL
K698-ub HRTPEETkLPEDQSC
K731-ub SEAQWRYkVVTSNQG
T734 QWRYkVVTSNQGSEE
S756 PIATRHSSLRRGRRT
S791 SELSTSTSEGSLSAV
Y864 ELMFVERYQEVIQEL
K877 ELARVEHKIENQNSD
N887 NQNSDGGNNTIRRTG
Y914 AAAGMVFYSISDVTE
S915 AAGMVFYSISDVTEK
T920 FYSISDVTEKLLSPS
S992 TAERRLSSSLESRGR
S993 AERRLSSSLESRGRR
K1036-ub LMQTGLAkSETLEER
R1043 kSETLEERGGGAPRS
K1095-ub ALALPESkSTPLSCL
K1127-ub IQSQLLQkTLGRQTP
S1262 LLDGLPLSTLGSPRP
S1281 SAERKSHSSPKDSLP
S1282 AERKSHSSPKDSLPA
K1321-ub SRGTKVSkPGLSWKE
K1459 WQYLFPVKDASLRSQ
Y1511 KLMELRVYQKILGLQ
K1586-ub LERSEHDkALQLLQR
K1717-ub LLSRYAGkALDLPyP
Y1723-p GkALDLPyPLREKRs
S1730-p yPLREKRsDsMIHLQ
S1732-p LREKRsDsMIHLQEP
S1754-p ETLSRSSsAEFSAAA
S1758 RSSsAEFSAAAAPGS
S1770-p PGSALVRsPsPKERA
S1772-p SALVRsPsPKERAFP
T1792-p VEFVPPEtPPARDQW
R1953 EHCCRLSRGLTNPEV
R2406 AARQLVEREKYGEIR
K2442-ac LNCLEAFkRIPPQEL
K2442-ub LNCLEAFkRIPPQEL
Y2466 DDNKVRAYLTCCKLR
  rat

 
S181 LLLEERHSASLCHSS
S187 HSASLCHSSLQKSLL
K295 PKASLSGKDHPDPER
K295 PKASLSGKDHPDPER
- gap
S420 LEWCVQQSSSLIPKR
S421 EWCVQQSSSLIPKRE
K465 EVLKLLQKVPTKDLQ
Y552 ASHLFPTYLARCRQY
Y596 EPHLPEDYAEDDDIE
G606 DDDIEGKGPWGLWsP
S612-p KGPWGLWsPSEsPQH
S614 PWGLWsPSEsPQHIA
S616-p GLWsPSEsPQHIAAT
- under review  
T658 DNSPGPHTHSFLDLK
R699 LNELSSHRTPEETEL
E705 HRTPEETELLEDQSC
K738 SEAQWRYKVVTSNQS
T741 QWRYKVVTSNQSSEE
S763 PTAKRHSSLRRGRRT
S798 SELSTSTSEGSLSAV
Y871 ELMFVERYQEVIQEL
K884 ELARVEHKIENQNSD
N894 NQNSDGGNNTVRRTG
Y921 AAAGMVFYSISDVTD
S922 AAGMVFYSISDVTDK
T927 FYSISDVTDKLLSPS
S999 TAERRLSSSLEGRGR
S1000 AERRLSSSLEGRGRR
K1043 LTVTGLTKSETLEER
R1050 KSETLEERGGGAPRC
K1102 ALTLSEPKSTPLTCL
K1134 IQSQLLQKTLGKQTL
S1269 LLDGLPLSVLGSPRP
- under review  
- under review  
R1328 SRGTKVSRPSLSWKE
K1466 WQYLFPVKDASLRSQ
Y1518 KLTELRVYQKILGLQ
K1593 LERREYEKALQLLQR
K1724 LLSRYAGKALDLPYP
Y1730 GKALDLPYPLREKRS
S1737 YPLREKRSDSMIHLQ
S1739 LREKRSDSMIHLQEP
S1761 ETLSRSSSAEFSAAA
S1765 RSSSAEFSAAAAAPA
S1783 PGSALVCSPSPKERA
S1785 SALVCSPSPKERAFP
T1805 LEFVPPETPPARDQW
R1966 EHCCRLSRGLTNPEV
K2419 AARQLVEKEKYGEIR
K2455 LNCLEAFKRIPPQEL
K2455 LNCLEAFKRIPPQEL
Y2479 DDNKVRAYLTCCKLR
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