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Protein Page:
KRas (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
KRas Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Ras; G protein; Motility/polarity/chemotaxis
Cellular Component: mitochondrion; plasma membrane; lipid raft
Molecular Function: protein binding; GDP binding; GTP binding; GMP binding; protein complex binding; LRR domain binding
Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; fibroblast growth factor receptor signaling pathway; activation of MAPKK activity; nerve growth factor receptor signaling pathway; cytokine and chemokine mediated signaling pathway; positive regulation of nitric-oxide synthase activity; response to glucocorticoid stimulus; MAPKKK cascade; response to mineralocorticoid stimulus; social behavior; activation of NF-kappaB transcription factor; positive regulation of MAP kinase activity; GTP catabolic process; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; positive regulation of protein amino acid phosphorylation; blood coagulation; leukocyte migration
Reference #:  P01116 (UniProtKB)
Alt. Names/Synonyms: c-K-ras; c-Ki-ras; c-Kirsten-ras protein; cellular c-Ki-ras2 proto-oncogene; GTPase KRas; GTPase KRas, N-terminally processed; K-Ras; K-Ras 2; K-ras p21 protein; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; Ki-Ras; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog; KRAS; KRAS1; KRAS2; NS; NS3; oncogene KRAS2; PR310 c-K-ras oncogene; RASK; RASK2; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Gene Symbols: KRAS
Molecular weight: 21,656 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

KRas

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T2-p ______MtEyKLVVV
0 1 Y4-p ____MtEyKLVVVGA
0 4 S39-p YDPTIEDsYRKQVVI
1 1 R41 PTIEDsYRKQVVIDG
1 1 K42 TIEDsYRKQVVIDGE
0 4 Y64-p DTAGQEEySAMRDQY
1 0 K104-u REQIKRVkDSEDVPM
0 2 K117-u PMVLVGNkCDLPSRT
0 33 K128-u PSRTVDTkQAQDLAR
1 5 K147-u PFIETSAkTRQRVED
0 14 Y157 QRVEDAFYTLVREIR
3 0 - gap
  KRas iso2  
T2 ______MTEYKLVVV
Y4 ____MTEYKLVVVGA
S39 YDPTIEDSYRKQVVI
R41 PTIEDSYRKQVVIDG
K42 TIEDSYRKQVVIDGE
Y64 DTAGQEEYSAMRDQY
K104 REQIKRVKDSEDVPM
K117 PMVLVGNKCDLPSRT
K128 PSRTVDTKQAQDLAR
K147 PFIETSAKTRQGVDD
Y157-p QGVDDAFyTLVREIR
S181-p GKKKKKKsKTKCVIM
  mouse

► Hide Isoforms
 
T2 ______MTEYKLVVV
Y4 ____MTEYKLVVVGA
S39-p YDPTIEDsYRKQVVI
R41 PTIEDsYRKQVVIDG
K42 TIEDsYRKQVVIDGE
Y64 DTAGQEEYSAMRDQY
K104 REQIKRVKDSEDVPM
K117-u PMVLVGNkCDLPSRT
K128-u PSRTVDTkQAQELAR
K147-u PFIETSAkTRQRVED
Y157 QRVEDAFYTLVREIR
- gap
  KRas iso2  
T2 ______MTEYKLVVV
Y4 ____MTEYKLVVVGA
S39 YDPTIEDSYRKQVVI
R41 PTIEDSYRKQVVIDG
K42 TIEDSYRKQVVIDGE
Y64 DTAGQEEYSAMRDQY
K104 REQIKRVKDSEDVPM
K117 PMVLVGNKCDLPSRT
K128 PSRTVDTKQAQELAR
K147 PFIETSAKTRQGVDD
Y157 QGVDDAFYTLVREIR
S181 GKKKKKKSRTRCTVM
  rat

 
T2 ______MTEYKLVVV
Y4 ____MTEYKLVVVGA
S39 YDPTIEDSYrkQVVI
R41-m2 PTIEDSYrkQVVIDG
K42-m2 TIEDSYrkQVVIDGE
Y64 DTAGQEEYSAMRDQY
K104 REQIKRVKDSEDVPM
K117 PMVLVGNKCDLPSRT
K128-u PSRTVDTkQAQELAR
K147 PFIETSAKTRQRVED
Y157 QRVEDAFYTLVREIR
- gap
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