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KRas
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: G protein; Motility/polarity/chemotaxis; G protein, monomeric (Ras) |
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Cellular Component: mitochondrion; plasma membrane; lipid raft
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Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GMP binding; LRR domain binding
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Biological Process: regulation of long-term neuronal synaptic plasticity; axon guidance; nerve growth factor receptor signaling pathway; activation of MAPKK activity; response to glucocorticoid stimulus; activation of NF-kappaB transcription factor; positive regulation of MAP kinase activity; small GTPase mediated signal transduction; positive regulation of cell proliferation; visual learning; negative regulation of neuron apoptosis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; positive regulation of nitric-oxide synthase activity; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; response to mineralocorticoid stimulus; social behavior; regulation of synaptic transmission, GABAergic; positive regulation of Rac protein signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; striated muscle cell differentiation; positive regulation of protein amino acid phosphorylation; actin cytoskeleton organization and biogenesis; blood coagulation; leukocyte migration
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Reference #:
P01116 (UniProtKB)
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| Alt. Names/Synonyms: c-K-ras; c-Ki-ras; c-Kirsten-ras protein; cellular c-Ki-ras2 proto-oncogene; GTPase KRas; GTPase KRas, N-terminally processed; K-Ras; K-Ras 2; K-ras p21 protein; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; Ki-Ras; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog; KRAS; KRAS1; KRAS2; NS; NS3; oncogene KRAS2; PR310 c-K-ras oncogene; RASK; RASK2; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
| Gene Symbols: KRAS |
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Molecular weight: 21,656 Da
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Basal Isoelectric point: 6.33
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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B Cell Receptor Signaling
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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GPCRs Signaling to MAPK/Erk
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Jak/Stat/IL-6 Signaling
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MAPK/Erk in Growth and Differentiation
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NF-kB Signaling
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Regulation of Actin Dynamics
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Warburg Effect
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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