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PPP2R4 (mouse)

Overview PPP2R4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activty of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A. Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB. Widely expressed. Belongs to the PTPA-type PPIase family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Protein phosphatase, regulatory subunit; EC 5.2.1.8; Motility/polarity/chemotaxis Cellular Component: cytoplasm; nucleus Molecular Function: protein homodimerization activity; peptidyl-prolyl cis-trans isomerase activity; protein phosphatase 2A binding; phosphatase activator activity; nucleotide binding; protein phosphatase type 2A regulator activity; isomerase activity; protein tyrosine phosphatase activator activity; ATP binding; receptor binding Biological Process: positive regulation of phosphoprotein phosphatase activity; positive regulation of catalytic activity; negative regulation of protein amino acid dephosphorylation; ATP catabolic process; protein folding; positive regulation of apoptosis; negative regulation of phosphoprotein phosphatase activity; regulation of phosphoprotein phosphatase activity; positive regulation of protein amino acid dephosphorylation Reference #:  P58389 (UniProtKB) Alt. Names/Synonyms: 2610042B21Rik; C77440; MGC60706; MGC7129; N28142; OTTMUSP00000018234; Phosphotyrosyl phosphatase activator; PP2A, subunit B', PR53 isoform; Ppp2r4; PR53; protein phosphatase 2A, regulatory subunit B (PR 53); PTPA; Serine/threonine-protein phosphatase 2A activator; Serine/threonine-protein phosphatase 2A regulatory subunit 4; Serine/threonine-protein phosphatase 2A regulatory subunit B' Gene Symbols: Ppp2r4 Molecular weight: 36,710 Da Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PPP2R4 2G62 - A=22-358 (human) 2HV6 - A/B=1-358 (human) 2HV7 - A/B/C/D/E/F/G/H=1-358 (human) 2IXM - A=20-357 (human)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		K27	TQNFIIPKKEIHTVP
0	1		K62	LNEGVKGKKLTFDYK
0	14		Y188	VFKVFDRYLEVMRKL
0	1		K242	PRHFVDEKAVSENHK
0	1		K296	QGLIRMYKAECLEKF
0	1		K302	YKAECLEKFPVIQHF
0	1		K310	FPVIQHFKFGSLLPI

	human
K27-u	TQNFIIPkKEIHTVP
K62-a	LNEGVKGkKLTFEYR
Y223-p	VFKVFNRyLEVMRKL
K277-u	PRHFVDEkAVNENHK
K331-a	QGLIRMYkAECLEkF
K337-a	YkAECLEkFPVIQHF
K345-a	FPVIQHFkFGSLLPI

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