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MAD2L1 (human)

Overview MAD2L1 required for the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. Inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. Interacts with Cdc20, MAD2L1BP and with ADAM17/TACE Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation Cellular Component: kinetochore; spindle pole; perinuclear region of cytoplasm; nuclear pore; nucleus; cytosol Molecular Function: protein binding; protein homodimerization activity Biological Process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitotic sister chromatid segregation; mitotic cell cycle checkpoint; M phase of mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle; negative regulation of protein catabolic process; cell cycle checkpoint; mitotic prometaphase; negative regulation of apoptosis Reference #:  Q13257 (UniProtKB) Alt. Names/Synonyms: HsMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2 mitotic arrest deficient-like 1 (yeast); MAD2-like protein 1; MAD2L1; MD2L1; Mitotic arrest deficient 2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1; Mitotic spindle assembly checkpoint protein MAD2A Gene Symbols: MAD2L1 Molecular weight: 23,510 Da Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MAD2L1 1DUJ - A=11-195 (human) 1GO4 - A/B/C/D=1-205 (human) 1KLQ - A=11-205 (human) 1S2H - A=1-205 (human) 2QYF - A/C=1-205 (human) 2V64 - F/A/C=2-205 H/D/E=118-205 (human) 2VFX - F/A/J/K/E/B/H/C/D/I/G/L=1-205 (human) 3GMH - F/A/J/K/E/B/H/C/D/I/G/L=11-205 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: S170‑p, S178‑p, S195‑p inhibition: S195‑p molecular association, regulation: S170‑p, S178‑p, S195‑p protein conformation: S170‑p, S185‑p, S195‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y77-p	EQLKDWLyKCSVQKL
0	30		K122-u	APREKSQkAIQDEIR
0	1		S130-p	AIQDEIRsVIRQITA
0	2		K166-u	KDLVVPEkWEEsGPQ
2	0		S170-p	VPEkWEEsGPQFITN
2	0		S178-p	GPQFITNsEEVRLRs
1	2		S185-p	sEEVRLRsFTTTIHk
0	1		K192-u	sFTTTIHkVNsMVAy
2	20		S195-p	TTIHkVNsMVAykIP
0	19		Y199-p	kVNsMVAykIPVND_
0	4		K200-u	VNsMVAykIPVND__
0	1		I201	NsMVAykIPVND___

	mouse
Y77	EQLKEWLYKCSVQKL
K122	VRREKSQKAIQDEIR
S130	AIQDEIRSVIRQITA
K166	KDLVVPEKWEESGPQ
S170	VPEKWEESGPQFITN
C178	GPQFITNCEEVRLRs
S185-p	CEEVRLRsFTTTIHK
K192	sFTTTIHKVNsMVAy
S195-p	TTIHKVNsMVAyKtP
Y199-p	KVNsMVAyKtPVND_
K200	VNsMVAyKtPVND__
T201-p	NsMVAyKtPVND___

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