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Protein Page:
MAD2L1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MAD2L1 required for the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. Inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. Interacts with Cdc20, MAD2L1BP and with ADAM17/TACE Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Cellular Component: kinetochore; spindle pole; perinuclear region of cytoplasm; nuclear pore; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity
Biological Process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitotic sister chromatid segregation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; negative regulation of mitotic cell cycle; mitotic cell cycle; negative regulation of protein catabolic process; negative regulation of apoptosis
Reference #:  Q13257 (UniProtKB)
Alt. Names/Synonyms: HsMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2 mitotic arrest deficient-like 1 (yeast); MAD2-like protein 1; MAD2L1; MD2L1; Mitotic arrest deficient 2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1; Mitotic spindle assembly checkpoint protein MAD2A
Gene Symbols: MAD2L1
Molecular weight: 23,510 Da
Basal Isoelectric point: 5.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAD2L1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S170‑p, S178‑p, S195‑p
activity, inhibited: S195‑p
molecular association, regulation: S170‑p, S178‑p, S195‑p
protein conformation: S170‑p, S185‑p, S195‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6-p __MALQLsREQGITL
0 1 Y77-p EQLKDWLyKCSVQKL
0 30 K122-ub APREKSQkAIQDEIR
0 2 S130-p AIQDEIRsVIRQITA
0 2 K166-ub KDLVVPEkWEEsGPQ
2 0 S170-p VPEkWEEsGPQFITN
2 0 S178-p GPQFITNsEEVRLRs
2 3 S185-p sEEVRLRsFtTTIHk
1 1 T187-p EVRLRsFtTTIHkVN
0 1 K192-ub sFtTTIHkVNsMVAy
2 27 S195-p TTIHkVNsMVAykIP
0 17 Y199-p kVNsMVAykIPVND_
0 4 K200-ub VNsMVAykIPVND__
0 1 I201 NsMVAykIPVND___
  mouse

 
A6 __MAQQLAREQGITL
Y77 EQLKEWLYKCSVQKL
K122 VRREKSQKAIQDEIR
S130 AIQDEIRSVIRQITA
K166 KDLVVPEKWEESGPQ
S170 VPEKWEESGPQFITN
C178 GPQFITNCEEVRLRs
S185-p CEEVRLRsFTTTIHK
T187 EVRLRsFTTTIHKVN
K192 sFTTTIHKVNsMVAy
S195-p TTIHKVNsMVAyKtP
Y199-p KVNsMVAyKtPVND_
K200 VNsMVAyKtPVND__
T201-p NsMVAyKtPVND___
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