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Protein Page:
CCT2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CCT2 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Cellular Component: chaperonin-containing T-complex; microtubule; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein binding; unfolded protein binding; ATP binding
Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; chaperone-mediated protein complex assembly
Reference #:  P78371 (UniProtKB)
Alt. Names/Synonyms: 99D8.1; CCT-beta; CCT2; CCTB; chaperonin containing t-complex polypeptide 1, beta subunit; chaperonin containing t-complex polypeptide 1, subunit 2; chaperonin containing TCP1, subunit 2; chaperonin containing TCP1, subunit 2 (beta); MGC142074; MGC142076; PRO1633; T-complex protein 1 subunit beta; T-complex protein 1, beta subunit; TCP-1-beta; TCPB
Gene Symbols: CCT2
Molecular weight: 57,488 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  MAPK/Erk in Growth and Differentiation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CCT2
Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S260‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 4 S3-p _____MAsLSLAPVN
0 1 K13-a LAPVNIFkAGADEER
0 3 K13-u LAPVNIFkAGADEER
0 1 T23-p ADEERAEtARLTsFI
0 2 S28-p AEtARLTsFIGAIAI
0 10 K40-u IAIGDLVkSTLGPkG
0 5 K46-u VkSTLGPkGMDKILL
0 1 K50 LGPkGMDKILLssGR
0 1 S54-p GMDKILLssGRDASL
0 1 S55-p MDKILLssGRDASLM
0 42 K72-u NDGATILkNIGVDNP
0 3 K82-u GVDNPAAkVLVDMSR
0 1 S115-p ELLREAEsLIAkkIH
0 7 K119-u EAEsLIAkkIHPQTI
0 1 K120-u AEsLIAkkIHPQTII
0 1 S150-p SSAVDHGsDEVkFRQ
0 7 K154-a DHGsDEVkFRQDLMN
0 7 K154-u DHGsDEVkFRQDLMN
0 1 T165-p DLMNIAGttLSSKLL
0 1 T166-p LMNIAGttLSSKLLT
0 1 K181-a HHKDHFTkLAVEAVL
0 6 K191-u VEAVLRLkGSGNLEA
0 2 K203-u LEAIHIIkkLGGSLA
0 2 K204-u EAIHIIkkLGGSLAD
0 11 K222-u DEGFLLDkkIGVNQP
0 6 K223-u EGFLLDkkIGVNQPK
0 1 K236-u PKRIENAkILIANTG
0 1 K248 NTGMDTDKIkIFGsR
0 4 K248-u NTGMDTDkIkIFGsR
0 4 K250-u GMDTDkIkIFGsRVR
0 6 S254-p DkIkIFGsRVRVDst
2 246 S260-p GsRVRVDstAkVAEI
0 29 T261-p sRVRVDstAkVAEIE
0 1 K263-u VRVDstAkVAEIEHA
0 3 K272-u AEIEHAEkEKMKEkV
0 1 K278-u EkEKMKEkVERILkH
0 21 K284-u EkVERILkHGINCFI
0 24 Y297-p FINRQLIyNYPEQLF
0 14 K342-u FDHPELVkLGSCkLI
0 20 K347-u LVkLGSCkLIEEVMI
0 1 T379-p TIVLRGAtQQILDEA
0 9 K402-u CVLAQTVkDSRTVYG
0 1 T422 MLMAHAVTQLANRTP
0 3 K431-a LANRTPGkEAVAMES
0 7 K431-u LANRTPGkEAVAMES
0 2 K441-a VAMESYAkALRMLPt
0 10 K441-u VAMESYAkALRMLPt
0 1 T448-p kALRMLPtIIADNAG
0 1 S470 AQLRAAHSEGNTTAG
0 12 K522-u LRVDNIIkAAPRkRV
0 13 K527-u IIkAAPRkRVPDHHP
  mouse

 
S3-p _____MAsLSLAPVN
K13 LAPVNIFKAGADEER
K13-u LAPVNIFkAGADEER
T23 ADEERAETARLSSFI
S28 AETARLSSFIGAIAI
K40-u IAIGDLVkSTLGPKG
K46 VkSTLGPKGMDkILL
K50-u LGPKGMDkILLSSGR
S54 GMDkILLSSGRDAAL
S55 MDkILLSSGRDAALM
K72-u NDGATILkNIGVDNP
K82 GVDNPAAKVLVDMSR
S115 ELLREAESLIAKKIH
K119 EAESLIAKKIHPQTI
K120 AESLIAKKIHPQTII
S150 SSAVDHGSDEARFWQ
R154 DHGSDEARFWQDLMN
R154 DHGSDEARFWQDLMN
T165 DLMNIAGTTLSSKLL
T166 LMNIAGTTLSSKLLT
K181 HHKDHFTKLAVEAVL
K191-u VEAVLRLkGSGNLEA
K203 LEAIHVIKkLGGSLA
K204-u EAIHVIKkLGGSLAD
K222-u DEGFLLDkKIGVNQP
K223 EGFLLDkKIGVNQPK
K236 PKRIENAKILIANTG
K248-a NTGMDTDkIkIFGSR
K248-u NTGMDTDkIkIFGSR
K250-u GMDTDkIkIFGSRVR
S254 DkIkIFGSRVRVDsT
S260-p GSRVRVDsTAKVAEI
T261 SRVRVDsTAKVAEIE
K263 VRVDsTAKVAEIEHA
K272 AEIEHAEKEKMKEKV
K278 EKEKMKEKVERILkH
K284-u EKVERILkHGINCFI
Y297-p FINRQLIyNYPEQLF
K342-u FDHPELVkLGSCKLI
K347 LVkLGSCKLIEEVMI
T379 TIVLRGATQQILDEA
K402 CVLAQTVKDPRTVYG
T422-p MLMAHAVtQLANRTP
K431 LANRTPGKEAVAMES
K431 LANRTPGKEAVAMES
K441 VAMESFAKALRMLPT
K441-u VAMESFAkALRMLPT
T448 kALRMLPTIIADNAG
S470-p AQLRAAHsEGHITAG
K522-u LRVDNIIkAAPRkRV
K527-u IIkAAPRkRVPDHHP
  cow

 
S3 _____MASLSLAPVN
K13 LAPVNIFKAGADEER
K13 LAPVNIFKAGADEER
T23 ADEERAETARLSSFI
S28 AETARLSSFIGAIAI
K40 IAIGDLVKSTLGPKG
K46 VKSTLGPKGMDKILL
K50 LGPKGMDKILLSSGR
S54 GMDKILLSSGRDASL
S55 MDKILLSSGRDASLM
K72 NDGATILKNIGVDNP
K82 GVDNPAAKVLVDMSR
S115 ELLREAESLIAKKIH
K119 EAESLIAKKIHPQTI
K120 AESLIAKKIHPQTII
S150 NSAVDHGSDEVKFRQ
K154 DHGSDEVKFRQDLMN
K154 DHGSDEVKFRQDLMN
T165 DLMNIAGTTLSSKLL
T166 LMNIAGTTLSSKLLT
K181 HHKDHFTKLAVEAVL
K191 VEAVLRLKGSGNLEA
K203 LEAIHVIKKLGGSLA
K204 EAIHVIKKLGGSLAD
K222 DEGFLLDKKIGVNQP
K223 EGFLLDKKIGVNQPK
K236 PKRIENAKILIANTG
K248 NTGMDTDKIKIFGSR
K248 NTGMDTDKIKIFGSR
K250 GMDTDKIKIFGSRVR
S254 DKIKIFGSRVRVDST
S260 GSRVRVDSTAKVAEI
T261 SRVRVDSTAKVAEIE
K263 VRVDSTAKVAEIEHA
K272 AEIEHAEKEKMKEKV
K278 EKEKMKEKVERILKH
K284 EKVERILKHGINCFI
Y297 FINRQLIYNYPEQLF
K342 FDHPELVKLGSCKLI
K347 LVKLGSCKLIEEVMI
T379 TIVLRGATQQILDEA
K402 CVLAQTVKDSRTVYG
T422 MLMAHAVTQLASRTP
K431 LASRTPGKEAVAMES
K431 LASRTPGKEAVAMES
K441 VAMESYAKALRMLPT
K441 VAMESYAKALRMLPT
T448 KALRMLPTIIADNAG
S470 AQLRAAHSEGKTTAG
K522 LRVDNIIKAAPRKRV
K527 IIKAAPRKRVPDHHP
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